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Targeting the tumor microenvironment to enhance antitumor immune responses

(2015) ONCOTARGET. 6(3). p.1359-1381
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Abstract
The identification of tumor-specific antigens and the immune responses directed against them has instigated the development of therapies to enhance antitumor immune responses. Most of these cancer immunotherapies are administered systemically rather than directly to tumors. Nonetheless, numerous studies have demonstrated that intratumoral therapy is an attractive approach, both for immunization and immunomodulation purposes. Injection, recruitment and/or activation of antigen-presenting cells in the tumor nest have been extensively studied as strategies to cross-prime immune responses. Moreover, delivery of stimulatory cytokines, blockade of inhibitory cytokines and immune checkpoint blockade have been explored to restore immunological fitness at the tumor site. These tumor-targeted therapies have the potential to induce systemic immunity without the toxicity that is often associated with systemic treatments. We review the most promising intratumoral immunotherapies, how these affect systemic antitumor immunity such that disseminated tumor cells are eliminated, and which approaches have been proven successful in animal models and patients.
Keywords
Immunotherapy, Intratumoral, Tumor microenvironment, Immunomodulation, Vaccination, GROWTH-FACTOR-BETA, COLONY-STIMULATING FACTOR, PHASE-I TRIAL, RECOMBINANT HUMAN INTERLEUKIN-12, NECROSIS-FACTOR-ALPHA, HUMAN DENDRITIC CELLS, BONE-MARROW CULTURES, ENCODING CD40 LIGAND, REGULATORY T-CELLS, CANCER-IMMUNOTHERAPY

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Citation

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Chicago
Van Der Jeught, Kevin, Lukasz Bialkowski, Lidia Daszkiewicz, Katrijn Broos, Cleo Goyvaerts, Dries Renmans, Sandra Van Lint, Carlo Heirman, Kris Thielemans, and Karine Breckpot. 2015. “Targeting the Tumor Microenvironment to Enhance Antitumor Immune Responses.” Oncotarget 6 (3): 1359–1381.
APA
Van Der Jeught, K., Bialkowski, L., Daszkiewicz, L., Broos, K., Goyvaerts, C., Renmans, D., Van Lint, S., et al. (2015). Targeting the tumor microenvironment to enhance antitumor immune responses. ONCOTARGET, 6(3), 1359–1381.
Vancouver
1.
Van Der Jeught K, Bialkowski L, Daszkiewicz L, Broos K, Goyvaerts C, Renmans D, et al. Targeting the tumor microenvironment to enhance antitumor immune responses. ONCOTARGET. 2015;6(3):1359–81.
MLA
Van Der Jeught, Kevin, Lukasz Bialkowski, Lidia Daszkiewicz, et al. “Targeting the Tumor Microenvironment to Enhance Antitumor Immune Responses.” ONCOTARGET 6.3 (2015): 1359–1381. Print.
@article{6964696,
  abstract     = {The identification of tumor-specific antigens and the immune responses directed against them has instigated the development of therapies to enhance antitumor immune responses. Most of these cancer immunotherapies are administered systemically rather than directly to tumors. Nonetheless, numerous studies have demonstrated that intratumoral therapy is an attractive approach, both for immunization and immunomodulation purposes. Injection, recruitment and/or activation of antigen-presenting cells in the tumor nest have been extensively studied as strategies to cross-prime immune responses. Moreover, delivery of stimulatory cytokines, blockade of inhibitory cytokines and immune checkpoint blockade have been explored to restore immunological fitness at the tumor site. These tumor-targeted therapies have the potential to induce systemic immunity without the toxicity that is often associated with systemic treatments. We review the most promising intratumoral immunotherapies, how these affect systemic antitumor immunity such that disseminated tumor cells are eliminated, and which approaches have been proven successful in animal models and patients.},
  author       = {Van Der Jeught, Kevin and Bialkowski, Lukasz and Daszkiewicz, Lidia and Broos, Katrijn and Goyvaerts, Cleo and Renmans, Dries and Van Lint, Sandra and Heirman, Carlo and Thielemans, Kris and Breckpot, Karine},
  issn         = {1949-2553},
  journal      = {ONCOTARGET},
  language     = {eng},
  number       = {3},
  pages        = {1359--1381},
  title        = {Targeting the tumor microenvironment to enhance antitumor immune responses},
  url          = {http://dx.doi.org/10.18632/oncotarget.3204},
  volume       = {6},
  year         = {2015},
}

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