Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model
- Author
- Caroline Meers, Gino Verleye (UGent) , Dirk Smeets, Hadewych Van Hauwermeiren and Dirk Loeckx
- Organization
- Abstract
- Background and aim Polyetheretherketone (PEEK) materials already have been used successfully in orthopedic and especially spine surgery. PEEK is radiolucent and comparable with bone regarding elasticity. However, PEEK is inert and the adhesion of PEEK implants to bone tissue proceeds slowly because of their relatively low biocompatibility. The aim of the study is to evaluate the effect of titanium and CaP coating on the adhesion of bone tissue. Material and Methods Six adult sheep (body weight 57.6 +/- 3.9 kg) were included in this study. Three different types of cylindrical dowels (12 mm length x 8 mm diameter) were implanted in long bones (tibia and femur): PEEK dowels without coating (the control group), and PEEK dowels with a nanocoating of calcium phosphate (CaP group) or titanium (titanium group). Animals were sacrificed after 6, 12 and 26 weeks. Dowels were explanted for micro CT and histology. Results Bone implant contact (BIC) ratio was significantly higher in the titanium versus control groups in the 6 to 12 weeks period (p = 0.03). The ratio between bone volume and tissue volume (BV/TV) was significantly higher in titanium versus control in the 6 to 12 weeks period (p = 0.02). A significant correlation between BIC and BV/TV was seen (r = 0.85, p < 0.05). Conclusion Coating of PEEK dowels with a nanocoating of titanium has beneficial effects on adhesion of bone tissue.
- Keywords
- Nanotopography, In vivo test, Polyetheretherketone, titanium, Bone ingrowth, spinal surgery
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-6960384
- MLA
- Meers, Caroline, et al. “Fine Grained Osseointegrative Coating Improves Biocompatibility of PEEK in Heterotopic Sheep Model.” INTERNATIONAL JOURNAL OF SPINE SURGERY, edited by Yuan Hansen, vol. 9, no. Special issue on Biomechanics, 2015, doi:10.14444/2035.
- APA
- Meers, C., Verleye, G., Smeets, D., Van Hauwermeiren, H., & Loeckx, D. (2015). Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model. INTERNATIONAL JOURNAL OF SPINE SURGERY, 9(Special issue on Biomechanics). https://doi.org/10.14444/2035
- Chicago author-date
- Meers, Caroline, Gino Verleye, Dirk Smeets, Hadewych Van Hauwermeiren, and Dirk Loeckx. 2015. “Fine Grained Osseointegrative Coating Improves Biocompatibility of PEEK in Heterotopic Sheep Model.” Edited by Yuan Hansen. INTERNATIONAL JOURNAL OF SPINE SURGERY 9 (Special issue on Biomechanics). https://doi.org/10.14444/2035.
- Chicago author-date (all authors)
- Meers, Caroline, Gino Verleye, Dirk Smeets, Hadewych Van Hauwermeiren, and Dirk Loeckx. 2015. “Fine Grained Osseointegrative Coating Improves Biocompatibility of PEEK in Heterotopic Sheep Model.” Ed by. Yuan Hansen. INTERNATIONAL JOURNAL OF SPINE SURGERY 9 (Special issue on Biomechanics). doi:10.14444/2035.
- Vancouver
- 1.Meers C, Verleye G, Smeets D, Van Hauwermeiren H, Loeckx D. Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model. Hansen Y, editor. INTERNATIONAL JOURNAL OF SPINE SURGERY. 2015;9(Special issue on Biomechanics).
- IEEE
- [1]C. Meers, G. Verleye, D. Smeets, H. Van Hauwermeiren, and D. Loeckx, “Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model,” INTERNATIONAL JOURNAL OF SPINE SURGERY, vol. 9, no. Special issue on Biomechanics, 2015.
@article{6960384,
abstract = {{Background and aim
Polyetheretherketone (PEEK) materials already have been used successfully in orthopedic and especially spine surgery. PEEK is radiolucent and comparable with bone regarding elasticity. However, PEEK is inert and the adhesion of PEEK implants to bone tissue proceeds slowly because of their relatively low biocompatibility. The aim of the study is to evaluate the effect of titanium and CaP coating on the adhesion of bone tissue.
Material and Methods
Six adult sheep (body weight 57.6 +/- 3.9 kg) were included in this study. Three different types of cylindrical dowels (12 mm length x 8 mm diameter) were implanted in long bones (tibia and femur): PEEK dowels without coating (the control group), and PEEK dowels with a nanocoating of calcium phosphate (CaP group) or titanium (titanium group). Animals were sacrificed after 6, 12 and 26 weeks. Dowels were explanted for micro CT and histology.
Results
Bone implant contact (BIC) ratio was significantly higher in the titanium versus control groups in the 6 to 12 weeks period (p = 0.03). The ratio between bone volume and tissue volume (BV/TV) was significantly higher in titanium versus control in the 6 to 12 weeks period (p = 0.02). A significant correlation between BIC and BV/TV was seen (r = 0.85, p < 0.05).
Conclusion
Coating of PEEK dowels with a nanocoating of titanium has beneficial effects on adhesion of bone tissue.}},
articleno = {{35}},
author = {{Meers, Caroline and Verleye, Gino and Smeets, Dirk and Van Hauwermeiren, Hadewych and Loeckx, Dirk}},
editor = {{Hansen, Yuan}},
issn = {{2211-4599}},
journal = {{INTERNATIONAL JOURNAL OF SPINE SURGERY}},
keywords = {{Nanotopography,In vivo test,Polyetheretherketone,titanium,Bone ingrowth,spinal surgery}},
language = {{eng}},
number = {{Special issue on Biomechanics}},
pages = {{9}},
title = {{Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model}},
url = {{http://doi.org/10.14444/2035}},
volume = {{9}},
year = {{2015}},
}
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