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A repressor protein complex regulates leaf growth in Arabidopsis

Nathalie Gonzalez Sanchez, Laurens Pauwels UGent, Alexandra Baekelandt UGent, Liesbeth De Milde UGent, Jelle Van Leene UGent, Nienke Besbrugge, Ken Heyndrickx, Amparo Cuéllar Pérez UGent, Astrid Nagels Durand, Rebecca De Clercq UGent, et al. (2015) PLANT CELL. 27(8). p.2273-2287
abstract
Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells. However, the mechanism controlling the asymmetric divisions of these stem cells prior to differentiation is not well understood. Here, we characterized PEAPOD (PPD) proteins, the only transcriptional regulators known to negatively regulate meristemoid division. PPD proteins interact with KIX8 and KIX9, which act as adaptor proteins for the corepressor TOPLESS. D3-type cyclin encoding genes were identified among direct targets of PPD2, being negatively regulated by PPDs and KIX8/9. Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves resulting from increased meristemoid amplifying divisions. The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SPLICE VARIANT, JAZ PROTEINS, TRANSCRIPTION FACTORS, KIX DOMAIN, STOMATAL DEVELOPMENT, ASYMMETRIC CELL-DIVISION, GENOME-WIDE ANALYSIS, CHIP-SEQ, THALIANA, GENES
journal title
PLANT CELL
Plant Cell
volume
27
issue
8
pages
2273 - 2287
Web of Science type
Article
Web of Science id
000361176000016
JCR category
PLANT SCIENCES
JCR impact factor
8.538 (2015)
JCR rank
4/209 (2015)
JCR quartile
1 (2015)
ISSN
1040-4651
DOI
10.1105/tpc.15.00006
project
Bioinformatics: from nucleotids to networks (N2N)
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
additional info
the first three authors contributed equally to this work ; correction published in: Plant Cell (2016) 28(3), 824 ; DOI 10.1105/tpc.16.00202
copyright statement
I have transferred the copyright for this publication to the publisher
id
6959047
handle
http://hdl.handle.net/1854/LU-6959047
date created
2015-10-13 12:05:28
date last changed
2017-03-01 13:03:10
@article{6959047,
  abstract     = {Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells. However, the mechanism controlling the asymmetric divisions of these stem cells prior to differentiation is not well understood. Here, we characterized PEAPOD (PPD) proteins, the only transcriptional regulators known to negatively regulate meristemoid division. PPD proteins interact with KIX8 and KIX9, which act as adaptor proteins for the corepressor TOPLESS. D3-type cyclin encoding genes were identified among direct targets of PPD2, being negatively regulated by PPDs and KIX8/9. Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves resulting from increased meristemoid amplifying divisions. The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls.},
  author       = {Gonzalez Sanchez, Nathalie and Pauwels, Laurens and Baekelandt, Alexandra and De Milde, Liesbeth and Van Leene, Jelle and Besbrugge, Nienke and Heyndrickx, Ken and Cu{\'e}llar P{\'e}rez, Amparo and Nagels Durand, Astrid and De Clercq, Rebecca and Van De Slijke, Eveline and Vanden Bossche, Robin and Eeckhout, Dominique and Gevaert, Kris and Vandepoele, Klaas and De Jaeger, Geert and Goossens, Alain and Inz{\'e}, Dirk},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {SPLICE VARIANT,JAZ PROTEINS,TRANSCRIPTION FACTORS,KIX DOMAIN,STOMATAL DEVELOPMENT,ASYMMETRIC CELL-DIVISION,GENOME-WIDE ANALYSIS,CHIP-SEQ,THALIANA,GENES},
  language     = {eng},
  number       = {8},
  pages        = {2273--2287},
  title        = {A repressor protein complex regulates leaf growth in Arabidopsis},
  url          = {http://dx.doi.org/10.1105/tpc.15.00006},
  volume       = {27},
  year         = {2015},
}

Chicago
Gonzalez Sanchez, Nathalie, Laurens Pauwels, Alexandra Baekelandt, Liesbeth De Milde, Jelle Van Leene, Nienke Besbrugge, Ken Heyndrickx, et al. 2015. “A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.” Plant Cell 27 (8): 2273–2287.
APA
Gonzalez Sanchez, N., Pauwels, L., Baekelandt, A., De Milde, L., Van Leene, J., Besbrugge, N., Heyndrickx, K., et al. (2015). A repressor protein complex regulates leaf growth in Arabidopsis. PLANT CELL, 27(8), 2273–2287.
Vancouver
1.
Gonzalez Sanchez N, Pauwels L, Baekelandt A, De Milde L, Van Leene J, Besbrugge N, et al. A repressor protein complex regulates leaf growth in Arabidopsis. PLANT CELL. 2015;27(8):2273–87.
MLA
Gonzalez Sanchez, Nathalie, Laurens Pauwels, Alexandra Baekelandt, et al. “A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.” PLANT CELL 27.8 (2015): 2273–2287. Print.