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A repressor protein complex regulates leaf growth in Arabidopsis

Nathalie Gonzalez Sanchez (UGent) , Laurens Pauwels (UGent) , Alexandra Baekelandt (UGent) , Liesbeth De Milde (UGent) , Jelle Van Leene (UGent) , Nienke Besbrugge, Ken Heyndrickx (UGent) , Amparo Cuéllar Pérez (UGent) , Astrid Nagels Durand (UGent) , Rebecca De Clercq (UGent) , et al.
(2015) PLANT CELL. 27(8). p.2273-2287
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Abstract
Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells. However, the mechanism controlling the asymmetric divisions of these stem cells prior to differentiation is not well understood. Here, we characterized PEAPOD (PPD) proteins, the only transcriptional regulators known to negatively regulate meristemoid division. PPD proteins interact with KIX8 and KIX9, which act as adaptor proteins for the corepressor TOPLESS. D3-type cyclin encoding genes were identified among direct targets of PPD2, being negatively regulated by PPDs and KIX8/9. Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves resulting from increased meristemoid amplifying divisions. The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls.
Keywords
SPLICE VARIANT, JAZ PROTEINS, TRANSCRIPTION FACTORS, KIX DOMAIN, STOMATAL DEVELOPMENT, ASYMMETRIC CELL-DIVISION, GENOME-WIDE ANALYSIS, CHIP-SEQ, THALIANA, GENES

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Citation

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MLA
Gonzalez Sanchez, Nathalie, et al. “A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.” PLANT CELL, vol. 27, no. 8, 2015, pp. 2273–87, doi:10.1105/tpc.15.00006.
APA
Gonzalez Sanchez, N., Pauwels, L., Baekelandt, A., De Milde, L., Van Leene, J., Besbrugge, N., … Inzé, D. (2015). A repressor protein complex regulates leaf growth in Arabidopsis. PLANT CELL, 27(8), 2273–2287. https://doi.org/10.1105/tpc.15.00006
Chicago author-date
Gonzalez Sanchez, Nathalie, Laurens Pauwels, Alexandra Baekelandt, Liesbeth De Milde, Jelle Van Leene, Nienke Besbrugge, Ken Heyndrickx, et al. 2015. “A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.” PLANT CELL 27 (8): 2273–87. https://doi.org/10.1105/tpc.15.00006.
Chicago author-date (all authors)
Gonzalez Sanchez, Nathalie, Laurens Pauwels, Alexandra Baekelandt, Liesbeth De Milde, Jelle Van Leene, Nienke Besbrugge, Ken Heyndrickx, Amparo Cuéllar Pérez, Astrid Nagels Durand, Rebecca De Clercq, Eveline Van De Slijke, Robin Vanden Bossche, Dominique Eeckhout, Kris Gevaert, Klaas Vandepoele, Geert De Jaeger, Alain Goossens, and Dirk Inzé. 2015. “A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis.” PLANT CELL 27 (8): 2273–2287. doi:10.1105/tpc.15.00006.
Vancouver
1.
Gonzalez Sanchez N, Pauwels L, Baekelandt A, De Milde L, Van Leene J, Besbrugge N, et al. A repressor protein complex regulates leaf growth in Arabidopsis. PLANT CELL. 2015;27(8):2273–87.
IEEE
[1]
N. Gonzalez Sanchez et al., “A repressor protein complex regulates leaf growth in Arabidopsis,” PLANT CELL, vol. 27, no. 8, pp. 2273–2287, 2015.
@article{6959047,
  abstract     = {{Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells. However, the mechanism controlling the asymmetric divisions of these stem cells prior to differentiation is not well understood. Here, we characterized PEAPOD (PPD) proteins, the only transcriptional regulators known to negatively regulate meristemoid division. PPD proteins interact with KIX8 and KIX9, which act as adaptor proteins for the corepressor TOPLESS. D3-type cyclin encoding genes were identified among direct targets of PPD2, being negatively regulated by PPDs and KIX8/9. Accordingly, kix8 kix9 mutants phenocopied PPD loss-of-function producing larger leaves resulting from increased meristemoid amplifying divisions. The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls.}},
  author       = {{Gonzalez Sanchez, Nathalie and Pauwels, Laurens and Baekelandt, Alexandra and De Milde, Liesbeth and Van Leene, Jelle and Besbrugge, Nienke and Heyndrickx, Ken and Cuéllar Pérez, Amparo and Nagels Durand, Astrid and De Clercq, Rebecca and Van De Slijke, Eveline and Vanden Bossche, Robin and Eeckhout, Dominique and Gevaert, Kris and Vandepoele, Klaas and De Jaeger, Geert and Goossens, Alain and Inzé, Dirk}},
  issn         = {{1040-4651}},
  journal      = {{PLANT CELL}},
  keywords     = {{SPLICE VARIANT,JAZ PROTEINS,TRANSCRIPTION FACTORS,KIX DOMAIN,STOMATAL DEVELOPMENT,ASYMMETRIC CELL-DIVISION,GENOME-WIDE ANALYSIS,CHIP-SEQ,THALIANA,GENES}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{2273--2287}},
  title        = {{A repressor protein complex regulates leaf growth in Arabidopsis}},
  url          = {{http://doi.org/10.1105/tpc.15.00006}},
  volume       = {{27}},
  year         = {{2015}},
}
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