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The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson’s disease

Sam Van Lier, Katja Batens (UGent) , Patrick Santens (UGent) , Dirk Van Roost (UGent) , Mieke Van Herreweghe (UGent) and Miet De Letter (UGent)
(2016) ACTA NEUROLOGICA BELGICA. 116(2). p.163-170
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Abstract
While the influence of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on the comprehension of pragmatic language in Parkinson's disease (PD) has been the focus of studies, its impact on production, however, has yet to be elucidated. (1) Investigating the inf luence of DBS STN on pragmatic language production in spontaneous speech by comparing different stimulation conditions and (2) evaluating the effect of asymmetric dopaminergic denervation. This paper included 18 patients with advanced idiopathic PD with STN DBS. [Ten PD patients with predominantly left hemispheric dopamine denervation (PD-left) and eight PD patients with predominantly right-hemispheric dopamine denervation (PD-right).] The pragmatic components 'communicative functions' and 'conversational skills' were evaluated by analysing the spontaneous language production in four stimulation conditions. STN stimulation did not appear to influence the pragmatic production skills. Only when asymmetric dopamine depletion was taken into account the parameter 'giving an explanation' interaction was detectable. STN DBS appears to have some influence on the production of pragmatic language depending on asymmetric dopaminergic denervation. Suggestions are made for further research of pragmatic production in Parkinson's disease.
Keywords
Subthalamic nucleus stimulation, Parkinson's disease, Pragmatic language production, Asymmetric dopaminergic denervation, DEEP BRAIN-STIMULATION, COMPREHENSION, ASYMMETRY, MIND, IMPAIRMENT, HEMISPHERE, ABILITIES, DEFICITS, FMRI

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Chicago
Van Lier, Sam, KATJA BATENS, Patrick Santens, Dirk Van Roost, Mieke Van Herreweghe, and Miet De Letter. 2016. “The Influence of Subthalamic Nucleus Stimulation on Pragmatic Language Production in Parkinson’s Disease.” Acta Neurologica Belgica 116 (2): 163–170.
APA
Van Lier, S., BATENS, K., Santens, P., Van Roost, D., Van Herreweghe, M., & De Letter, M. (2016). The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson’s disease. ACTA NEUROLOGICA BELGICA, 116(2), 163–170.
Vancouver
1.
Van Lier S, BATENS K, Santens P, Van Roost D, Van Herreweghe M, De Letter M. The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson’s disease. ACTA NEUROLOGICA BELGICA. 2016;116(2):163–70.
MLA
Van Lier, Sam, KATJA BATENS, Patrick Santens, et al. “The Influence of Subthalamic Nucleus Stimulation on Pragmatic Language Production in Parkinson’s Disease.” ACTA NEUROLOGICA BELGICA 116.2 (2016): 163–170. Print.
@article{6957791,
  abstract     = {While the influence of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on the comprehension of pragmatic language in Parkinson's disease (PD) has been the focus of studies, its impact on production, however, has yet to be elucidated. (1) Investigating the inf luence of DBS STN on pragmatic language production in spontaneous speech by comparing different stimulation conditions and (2) evaluating the effect of asymmetric dopaminergic denervation. This paper included 18 patients with advanced idiopathic PD with STN DBS. [Ten PD patients with predominantly left hemispheric dopamine denervation (PD-left) and eight PD patients with predominantly right-hemispheric dopamine denervation (PD-right).] The pragmatic components 'communicative functions' and 'conversational skills' were evaluated by analysing the spontaneous language production in four stimulation conditions. STN stimulation did not appear to influence the pragmatic production skills. Only when asymmetric dopamine depletion was taken into account the parameter 'giving an explanation' interaction was detectable. STN DBS appears to have some influence on the production of pragmatic language depending on asymmetric dopaminergic denervation. Suggestions are made for further research of pragmatic production in Parkinson's disease.},
  author       = {Van Lier, Sam and Batens, Katja and Santens, Patrick and Van Roost, Dirk and Van Herreweghe, Mieke and De Letter, Miet},
  issn         = {0300-9009},
  journal      = {ACTA NEUROLOGICA BELGICA},
  keyword      = {Subthalamic nucleus stimulation,Parkinson's disease,Pragmatic language production,Asymmetric dopaminergic denervation,DEEP BRAIN-STIMULATION,COMPREHENSION,ASYMMETRY,MIND,IMPAIRMENT,HEMISPHERE,ABILITIES,DEFICITS,FMRI},
  language     = {eng},
  number       = {2},
  pages        = {163--170},
  title        = {The influence of subthalamic nucleus stimulation on pragmatic language production in Parkinson{\textquoteright}s disease},
  url          = {http://dx.doi.org/10.1007/s13760-015-0546-5},
  volume       = {116},
  year         = {2016},
}

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