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Acute Liver Transplant Rejection Upon Immunosuppression Withdrawal in a Tolerance Induction Trial: Potential Role of IFN-gamma-secreting CD8(+) T Cells

Vincent Donckier, Ligia Craciun, Valerio Lucidi, Alexis Buggenhout, Roberto Troisi UGent, Xavier Rogiers UGent, Nathalie Boon, Thierry Gustot, Christophe Moreno and Nadine Bourgeois, et al. (2009) Transplantation. 87(9). p.S91-S95
abstract
We designed a pilot trial in cadaveric liver transplantation to determine whether induction with antithymocyte globulins (ATG) and sirolimus would allow immunosuppression withdrawal. Patients received ATG 3.75 mg/kg per day from day 1 to 5 after transplantation followed by sirolimus for 4 to 6 months. We monitored interleukin (IL)-7 serum levels, interferon (IFN)-gamma, and IL-2 mRNA accumulation in mixed leukocyte reaction and intragraft IFN-gamma mRNA expression. In the first three patients, immunosuppression discontinuation was followed by reversible acute rejection occurring on days 280, 246, and 163 posttransplantation, corresponding to days 140, 40, and 39 after drug withdrawal, respectively. At the time of rejection, blood CD8(+) T-cells counts had returned to or above pretransplant levels in two of three patients, whereas CD4(+) T-cell count remained low. IL-7 serum levels rose in all three patients in the first months after transplantation and IFN-gamma mRNA accumulated in mixed leukocyte reaction between recipient T cells and donor spleen cells at the time of rejection. High levels of IFN-gamma mRNA were consistently detected in liver biopsy performed at the time of rejection. In conclusion, lymphopenia-induced IL-7 production after induction with ATG and sirolimus might lead to emergence of IFN-gamma-secreting CD8(+) T-cells responsible for acute rejection after immunosuppression withdrawal.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
journal title
Transplantation
volume
87
issue
9
pages
S91 - S95
conference name
8th Beaune Seminar in Transplantation Research
conference location
Beaune, France
conference start
2008-06-12
conference end
2008-06-13
Web of Science type
Proceedings Paper
Web of Science id
000266048200019
JCR category
SURGERY
JCR impact factor
3.498 (2009)
JCR rank
15/166 (2009)
JCR quartile
1 (2009)
ISSN
0041-1337
DOI
10.1097/TP.0b013e3181a2dee6
language
English
UGent publication?
yes
classification
A1
id
695738
handle
http://hdl.handle.net/1854/LU-695738
date created
2009-06-13 09:56:24
date last changed
2009-06-22 15:39:55
@article{695738,
  abstract     = {We designed a pilot trial in cadaveric liver transplantation to determine whether induction with antithymocyte globulins (ATG) and sirolimus would allow immunosuppression withdrawal. Patients received ATG 3.75 mg/kg per day from day 1 to 5 after transplantation followed by sirolimus for 4 to 6 months. We monitored interleukin (IL)-7 serum levels, interferon (IFN)-gamma, and IL-2 mRNA accumulation in mixed leukocyte reaction and intragraft IFN-gamma mRNA expression. In the first three patients, immunosuppression discontinuation was followed by reversible acute rejection occurring on days 280, 246, and 163 posttransplantation, corresponding to days 140, 40, and 39 after drug withdrawal, respectively. At the time of rejection, blood CD8(+) T-cells counts had returned to or above pretransplant levels in two of three patients, whereas CD4(+) T-cell count remained low. IL-7 serum levels rose in all three patients in the first months after transplantation and IFN-gamma mRNA accumulated in mixed leukocyte reaction between recipient T cells and donor spleen cells at the time of rejection. High levels of IFN-gamma mRNA were consistently detected in liver biopsy performed at the time of rejection. In conclusion, lymphopenia-induced IL-7 production after induction with ATG and sirolimus might lead to emergence of IFN-gamma-secreting CD8(+) T-cells responsible for acute rejection after immunosuppression withdrawal.},
  author       = {Donckier, Vincent and Craciun, Ligia and Lucidi, Valerio and Buggenhout, Alexis and Troisi, Roberto and Rogiers, Xavier and Boon, Nathalie and Gustot, Thierry and Moreno, Christophe and Bourgeois, Nadine and Colle, Isabelle and Van Vlierberghe, Hans and Nagy, Nathalie and Praet, Marleen and Dernies, Tiffany and Amrani, Mohammed and Stordeur, Patrick and de Hemptinne, Bernard and Goldman, Michel},
  issn         = {0041-1337},
  journal      = {Transplantation},
  language     = {eng},
  location     = {Beaune, France},
  number       = {9},
  pages        = {S91--S95},
  title        = {Acute Liver Transplant Rejection Upon Immunosuppression Withdrawal in a Tolerance Induction Trial: Potential Role of IFN-gamma-secreting CD8(+) T Cells},
  url          = {http://dx.doi.org/10.1097/TP.0b013e3181a2dee6},
  volume       = {87},
  year         = {2009},
}

Chicago
Donckier, Vincent, Ligia Craciun, Valerio Lucidi, Alexis Buggenhout, Roberto Troisi, Xavier Rogiers, Nathalie Boon, et al. 2009. “Acute Liver Transplant Rejection Upon Immunosuppression Withdrawal in a Tolerance Induction Trial: Potential Role of IFN-gamma-secreting CD8(+) T Cells.” Transplantation 87 (9): S91–S95.
APA
Donckier, V., Craciun, L., Lucidi, V., Buggenhout, A., Troisi, R., Rogiers, X., Boon, N., et al. (2009). Acute Liver Transplant Rejection Upon Immunosuppression Withdrawal in a Tolerance Induction Trial: Potential Role of IFN-gamma-secreting CD8(+) T Cells. Transplantation, 87(9), S91–S95. Presented at the 8th Beaune Seminar in Transplantation Research.
Vancouver
1.
Donckier V, Craciun L, Lucidi V, Buggenhout A, Troisi R, Rogiers X, et al. Acute Liver Transplant Rejection Upon Immunosuppression Withdrawal in a Tolerance Induction Trial: Potential Role of IFN-gamma-secreting CD8(+) T Cells. Transplantation. 2009;87(9):S91–S95.
MLA
Donckier, Vincent, Ligia Craciun, Valerio Lucidi, et al. “Acute Liver Transplant Rejection Upon Immunosuppression Withdrawal in a Tolerance Induction Trial: Potential Role of IFN-gamma-secreting CD8(+) T Cells.” Transplantation 87.9 (2009): S91–S95. Print.