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The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 antagonistically regulate mannitol-induced growth inhibition in Arabidopsis

(2015) PLANT PHYSIOLOGY. 169(1). p.166-179
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Biotechnology for a sustainable economy (Bio-Economy)
Abstract
Leaf growth is a tightly regulated and complex process, which responds in a dynamic manner to changing environmental conditions, but the mechanisms that reduce growth under adverse conditions are rather poorly understood. We previously identified a growth inhibitory pathway regulating leaf growth upon exposure to a low concentration of mannitol and characterized the ETHYLENE RESPONSE FACTOR (ERF)/APETALA2 transcription factor ERF6 as a central activator of both leaf growth inhibition and induction of stress tolerance genes. Here, we describe the role of the transcriptional repressor ERF11 in relation to the ERF6-mediated stress response in Arabidopsis (Arabidopsis thaliana). Using inducible overexpression lines, we show that ERF6 induces the expression of ERF11. ERF11 in turn molecularly counteracts the action of ERF6 and represses at least some of the ERF6-induced genes by directly competing for the target gene promoters. As a phenotypical consequence of the ERF6-ERF11 antagonism, the extreme dwarfism caused by ERF6 overexpression is suppressed by overexpression of ERF11. Together, our data demonstrate that dynamic mechanisms exist to fine-tune the stress response and that ERF11 counteracts ERF6 to maintain a balance between plant growth and stress defense.
Keywords
GENE-EXPRESSION, TRANSCRIPTION FACTOR HY5, DNA-BINDING, LEAF DEVELOPMENT, ABSCISIC-ACID, ANALYSIS REVEALS, BINDING-SITES, WATER-LIMITING CONDITIONS, OSMOTIC-STRESS, THALIANA

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MLA
Dubois, Marieke et al. “The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 Antagonistically Regulate Mannitol-induced Growth Inhibition in Arabidopsis.” PLANT PHYSIOLOGY 169.1 (2015): 166–179. Print.
APA
Dubois, M., Van den Broeck, L., Claeys, H., Van Vlierberghe, K., Matsui, M., & Inzé, D. (2015). The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 antagonistically regulate mannitol-induced growth inhibition in Arabidopsis. PLANT PHYSIOLOGY, 169(1), 166–179.
Chicago author-date
Dubois, Marieke, Lisa Van den Broeck, Hannes Claeys, Kaatje Van Vlierberghe, Minami Matsui, and Dirk Inzé. 2015. “The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 Antagonistically Regulate Mannitol-induced Growth Inhibition in Arabidopsis.” Plant Physiology 169 (1): 166–179.
Chicago author-date (all authors)
Dubois, Marieke, Lisa Van den Broeck, Hannes Claeys, Kaatje Van Vlierberghe, Minami Matsui, and Dirk Inzé. 2015. “The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 Antagonistically Regulate Mannitol-induced Growth Inhibition in Arabidopsis.” Plant Physiology 169 (1): 166–179.
Vancouver
1.
Dubois M, Van den Broeck L, Claeys H, Van Vlierberghe K, Matsui M, Inzé D. The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 antagonistically regulate mannitol-induced growth inhibition in Arabidopsis. PLANT PHYSIOLOGY. 2015;169(1):166–79.
IEEE
[1]
M. Dubois, L. Van den Broeck, H. Claeys, K. Van Vlierberghe, M. Matsui, and D. Inzé, “The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 antagonistically regulate mannitol-induced growth inhibition in Arabidopsis,” PLANT PHYSIOLOGY, vol. 169, no. 1, pp. 166–179, 2015.
@article{6951284,
  abstract     = {Leaf growth is a tightly regulated and complex process, which responds in a dynamic manner to changing environmental conditions, but the mechanisms that reduce growth under adverse conditions are rather poorly understood. We previously identified a growth inhibitory pathway regulating leaf growth upon exposure to a low concentration of mannitol and characterized the ETHYLENE RESPONSE FACTOR (ERF)/APETALA2 transcription factor ERF6 as a central activator of both leaf growth inhibition and induction of stress tolerance genes. Here, we describe the role of the transcriptional repressor ERF11 in relation to the ERF6-mediated stress response in Arabidopsis (Arabidopsis thaliana). Using inducible overexpression lines, we show that ERF6 induces the expression of ERF11. ERF11 in turn molecularly counteracts the action of ERF6 and represses at least some of the ERF6-induced genes by directly competing for the target gene promoters. As a phenotypical consequence of the ERF6-ERF11 antagonism, the extreme dwarfism caused by ERF6 overexpression is suppressed by overexpression of ERF11. Together, our data demonstrate that dynamic mechanisms exist to fine-tune the stress response and that ERF11 counteracts ERF6 to maintain a balance between plant growth and stress defense.},
  author       = {Dubois, Marieke and Van den Broeck, Lisa and Claeys, Hannes and Van Vlierberghe, Kaatje and Matsui, Minami and Inzé, Dirk},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keywords     = {GENE-EXPRESSION,TRANSCRIPTION FACTOR HY5,DNA-BINDING,LEAF DEVELOPMENT,ABSCISIC-ACID,ANALYSIS REVEALS,BINDING-SITES,WATER-LIMITING CONDITIONS,OSMOTIC-STRESS,THALIANA},
  language     = {eng},
  number       = {1},
  pages        = {166--179},
  title        = {The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 antagonistically regulate mannitol-induced growth inhibition in Arabidopsis},
  url          = {http://dx.doi.org/10.1104/pp.15.00335},
  volume       = {169},
  year         = {2015},
}

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