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Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings

H. Piessevaux, B. De Winter, E. Louis, V. Muls, Danny De Looze UGent, P. Pelckmans, M. Deltenre, D. Urbain and J. Tack (2009) NEUROGASTROENTEROLOGY AND MOTILITY. 21(4). p.378-388
abstract
Both dyspeptic and gastro-oesophageal reflux-like symptoms are frequent in the general population, but their degree of overlap is unknown. In severe functional dyspepsia (FD), symptoms are organized in factors associated with pathophysiological mechanisms. The aims of this study were: (i) to assess the prevalence of dyspeptic symptoms with and without overlapping reflux symptoms in the general population and their impact on daily life and on healthcare utilization; and (ii) to compare symptom groupings in the general population to FD patients. A total of 2025 subjects, representative of the Belgian general population, were used in this study. The subjects were submitted to a questionnaire with validated questions on their dyspeptic and reflux symptoms and with evaluators of impact on daily life and use of healthcare resources. Significant dyspeptic symptoms were found in 417 (20.6%). Overlapping reflux symptoms were present in 141 (33.8%). In this group, symptoms were more frequent and more severe. Dyspeptic symptoms induced weight loss (12.7%) and absenteeism (12.4%), affected daily life (61.2%) and generated use of healthcare resources, such as medical consultations (61.4%) and medication (70.9%). Factor analysis revealed a three-component structure with factor 1 including fullness, bloating and early satiety, factor 2 including nausea and vomiting and factor 3 including discomfort, pain, belching and reflux. If forced in a four-factor model, the analysis separates belching as independent factor. Dyspeptic symptoms are frequent in the general population, with overlapping reflux symptoms and increased symptom burden in about a third.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
NEUROGASTROENTEROLOGY AND MOTILITY
Neurogastroenterol. Motil.
volume
21
issue
4
pages
378 - 388
Web of Science type
Article
Web of Science id
000264165200005
JCR category
CLINICAL NEUROLOGY
JCR impact factor
3.568 (2009)
JCR rank
33/165 (2009)
JCR quartile
1 (2009)
ISSN
1350-1925
DOI
10.1111/j.1365-2982.2009.01262.x
language
English
UGent publication?
yes
classification
A1
id
694920
handle
http://hdl.handle.net/1854/LU-694920
date created
2009-06-12 16:14:40
date last changed
2009-06-22 15:03:51
@article{694920,
  abstract     = {Both dyspeptic and gastro-oesophageal reflux-like symptoms are frequent in the general population, but their degree of overlap is unknown. In severe functional dyspepsia (FD), symptoms are organized in factors associated with pathophysiological mechanisms. The aims of this study were: (i) to assess the prevalence of dyspeptic symptoms with and without overlapping reflux symptoms in the general population and their impact on daily life and on healthcare utilization; and (ii) to compare symptom groupings in the general population to FD patients. A total of 2025 subjects, representative of the Belgian general population, were used in this study. The subjects were submitted to a questionnaire with validated questions on their dyspeptic and reflux symptoms and with evaluators of impact on daily life and use of healthcare resources. Significant dyspeptic symptoms were found in 417 (20.6\%). Overlapping reflux symptoms were present in 141 (33.8\%). In this group, symptoms were more frequent and more severe. Dyspeptic symptoms induced weight loss (12.7\%) and absenteeism (12.4\%), affected daily life (61.2\%) and generated use of healthcare resources, such as medical consultations (61.4\%) and medication (70.9\%). Factor analysis revealed a three-component structure with factor 1 including fullness, bloating and early satiety, factor 2 including nausea and vomiting and factor 3 including discomfort, pain, belching and reflux. If forced in a four-factor model, the analysis separates belching as independent factor. Dyspeptic symptoms are frequent in the general population, with overlapping reflux symptoms and increased symptom burden in about a third.},
  author       = {Piessevaux, H. and De Winter, B. and Louis, E. and Muls, V. and De Looze, Danny and Pelckmans, P. and Deltenre, M. and Urbain, D. and Tack, J.},
  issn         = {1350-1925},
  journal      = {NEUROGASTROENTEROLOGY AND MOTILITY},
  language     = {eng},
  number       = {4},
  pages        = {378--388},
  title        = {Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings},
  url          = {http://dx.doi.org/10.1111/j.1365-2982.2009.01262.x},
  volume       = {21},
  year         = {2009},
}

Chicago
Piessevaux, H., B. De Winter, E. Louis, V. Muls, Danny De Looze, P. Pelckmans, M. Deltenre, D. Urbain, and J. Tack. 2009. “Dyspeptic Symptoms in the General Population: a Factor and Cluster Analysis of Symptom Groupings.” Neurogastroenterology and Motility 21 (4): 378–388.
APA
Piessevaux, H., De Winter, B., Louis, E., Muls, V., De Looze, D., Pelckmans, P., Deltenre, M., et al. (2009). Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings. NEUROGASTROENTEROLOGY AND MOTILITY, 21(4), 378–388.
Vancouver
1.
Piessevaux H, De Winter B, Louis E, Muls V, De Looze D, Pelckmans P, et al. Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings. NEUROGASTROENTEROLOGY AND MOTILITY. 2009;21(4):378–88.
MLA
Piessevaux, H., B. De Winter, E. Louis, et al. “Dyspeptic Symptoms in the General Population: a Factor and Cluster Analysis of Symptom Groupings.” NEUROGASTROENTEROLOGY AND MOTILITY 21.4 (2009): 378–388. Print.