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Influence of chemotherapy on the biodistribution of [99mTc]hydrazinonicotinamide annexin V in cancer patients

Sylvie Rottey UGent, BIEKE VAN DEN BOSSCHE UGent, G Slegers, Simon Van Belle UGent and Christophe Van De Wiele UGent (2009) QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 53(2). p.127-132
abstract
Aim. The aim of this study was to determine whether administration of chemotherapy interferes with the quantitative uptake of [(99)mTc]hydrazinonicotinamide (HYNIC) annexin V in normal human tissues at 5-7 h and 40-44 h after treatment initiation. Methods. Eleven cancer patients were prospectively included in this study after written informed consent. Five patients underwent two scintigraphic scans with [Tc-99m]HYNIC annexin V within 40-44 h from each other without any treatment given in between (control group or group 1). Six other patients starting a new chemotherapy or bisphosphonate regimen (treated group or group 2) underwent a scintigraphic scan with [Tc-99m]HYNIC annexin V pretreatment (within I week of treatment initiation) and at 5-7 h and 40-44 h following treatment initiation. Whole-body and organ-specific geometric mean counts, corrected for background activity, were obtained from regions of interest drawn on the earliest images and kept constant over all subsequent images per patient. Differences in whole-body and organ uptake between successive scans were assessed using non-parametric statistics. Results. No significant differences in mean percentages of injected dose uptake in whole body or organ tissues were observed between scan I and scan 2 in the control group and between scan 1, 2, and 3 in the treated group. Conclusion. Prior administration of [Tc-99m]HYNIC annexin V and administration of chemotherapy does not interfere with quantitative specific uptake in healthy human tissues when using a schedule of baseline and 5-7 h and 40-44 h post-treatment imaging.
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alternative title
Influence of chemotherapy on the biodistribution of [Tc-99m]hydrazinonicotinamide annexin V in cancer patients
Influence of chemotherapy on the biodistribution of [(99m)Tc]hydrazinonicotinamide annexin V in cancer patients
year
type
journalArticle (original)
publication status
published
subject
keyword
Annexins, Drug therapy, technetium Tc 99m hydrazinonicotinamide-annexin V, Neoplasms, IN-VIVO, APOPTOTIC CELLS, TUMOR RESPONSE, TC-99M-ANNEXIN-V, MICROPARTICLES, ENGULFMENT, BINDING
journal title
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Q. J. Nucl. Med. Mol. Imag.
volume
53
issue
2
pages
127 - 132
Web of Science type
Article
Web of Science id
000267026400002
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.877 (2009)
JCR rank
23/104 (2009)
JCR quartile
1 (2009)
ISSN
1824-4661
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
694147
handle
http://hdl.handle.net/1854/LU-694147
alternative location
http://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2009N02A0127
date created
2009-06-12 14:47:41
date last changed
2011-05-10 11:09:42
@article{694147,
  abstract     = {Aim. The aim of this study was to determine whether administration of chemotherapy interferes with the quantitative uptake of [(99)mTc]hydrazinonicotinamide (HYNIC) annexin V in normal human tissues at 5-7 h and 40-44 h after treatment initiation.
Methods. Eleven cancer patients were prospectively included in this study after written informed consent. Five patients underwent two scintigraphic scans with [Tc-99m]HYNIC annexin V within 40-44 h from each other without any treatment given in between (control group or group 1). Six other patients starting a new chemotherapy or bisphosphonate regimen (treated group or group 2) underwent a scintigraphic scan with [Tc-99m]HYNIC annexin V pretreatment (within I week of treatment initiation) and at 5-7 h and 40-44 h following treatment initiation. Whole-body and organ-specific geometric mean counts, corrected for background activity, were obtained from regions of interest drawn on the earliest images and kept constant over all subsequent images per patient. Differences in whole-body and organ uptake between successive scans were assessed using non-parametric statistics.
Results. No significant differences in mean percentages of injected dose uptake in whole body or organ tissues were observed between scan I and scan 2 in the control group and between scan 1, 2, and 3 in the treated group.
Conclusion. Prior administration of [Tc-99m]HYNIC annexin V and administration of chemotherapy does not interfere with quantitative specific uptake in healthy human tissues when using a schedule of baseline and 5-7 h and 40-44 h post-treatment imaging.},
  author       = {Rottey, Sylvie and VAN DEN BOSSCHE, BIEKE and Slegers, G and Van Belle, Simon and Van De Wiele, Christophe},
  issn         = {1824-4661},
  journal      = {QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {Annexins,Drug therapy,technetium Tc 99m hydrazinonicotinamide-annexin V,Neoplasms,IN-VIVO,APOPTOTIC CELLS,TUMOR RESPONSE,TC-99M-ANNEXIN-V,MICROPARTICLES,ENGULFMENT,BINDING},
  language     = {eng},
  number       = {2},
  pages        = {127--132},
  title        = {Influence of chemotherapy on the biodistribution of [99mTc]hydrazinonicotinamide annexin V in cancer patients},
  url          = {http://www.minervamedica.it/en/journals/nuclear-med-molecular-imaging/article.php?cod=R39Y2009N02A0127},
  volume       = {53},
  year         = {2009},
}

Chicago
Rottey, Sylvie, BIEKE VAN DEN BOSSCHE, G Slegers, Simon Van Belle, and Christophe Van De Wiele. 2009. “Influence of Chemotherapy on the Biodistribution of [99mTc]hydrazinonicotinamide Annexin V in Cancer Patients.” Quarterly Journal of Nuclear Medicine and Molecular Imaging 53 (2): 127–132.
APA
Rottey, S., VAN DEN BOSSCHE, B., Slegers, G., Van Belle, S., & Van De Wiele, C. (2009). Influence of chemotherapy on the biodistribution of [99mTc]hydrazinonicotinamide annexin V in cancer patients. QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 53(2), 127–132.
Vancouver
1.
Rottey S, VAN DEN BOSSCHE B, Slegers G, Van Belle S, Van De Wiele C. Influence of chemotherapy on the biodistribution of [99mTc]hydrazinonicotinamide annexin V in cancer patients. QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;53(2):127–32.
MLA
Rottey, Sylvie, BIEKE VAN DEN BOSSCHE, G Slegers, et al. “Influence of Chemotherapy on the Biodistribution of [99mTc]hydrazinonicotinamide Annexin V in Cancer Patients.” QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 53.2 (2009): 127–132. Print.