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Persistent decline over 3 years in physical function predicts 15-year mortality in ambulatory older men

Stefanie De Buyser (UGent) , Mirko Petrovic (UGent) , Youri Taes (UGent) , Bruno Lapauw (UGent) , Kaatje Toye (UGent) , Jean Kaufman (UGent) and Stefan Goemaere (UGent)
(2015) EUROPEAN GERIATRIC MEDICINE. 6(suppl. 1). p.S8-S8
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Abstract
Objectives: Physical function measurements can predict important adverse outcomes in older persons, but little is known about the predictive value of longitudinal changes in these measurements. This study evaluated the effects of transient and persistent decline over three years from baseline in physical function on 12 year mortality. Methods: This community-based cohort study included ambulatory men aged ≥71, living in the community of Merelbeke (municipality of Ghent, Belgium). Participants’ physical function and decline from baseline were assessed annually over three years using the following measurements and cut-off points: Timed Up and Go (2 sec), Chair Rise (1 sec), Balance (1 point), Grip strength (6kg), General Health (Short Form-36 item; 15 points), Physical Function (Short Form-36 item; 20 points) and Activities of Daily Living (ADL; Rapid Disability Rating Scale-2 questions; 2 points). Decline was considered persistent or transient based on whether the decline was still present at the end of year three. Results: Of 162 older men with complete annual physical function assessments from 1997 until 2000, 107 (66%) died within the subsequent 12 years. Mortality risk increased with persistent decline in Timed Up and Go (HR=2.15, 95%CI=1.24–3.73), Grip strength (HR=3.39, 95% CI=1.45–7.93), Physical Function (HR=2.51, 95%CI=1.43–4.41), General Health (HR=3.07, 95%CI=1.69–5.60), and ADL score (HR=3.30, 95%CI=1.43–7.63), compared with no decline. Decline in the last year in Chair Rise time (HR=2.63, 95%CI=1.39–4.98) and Balance (HR=2.39, 95%CI=1.10–5.18) also predicted death. Conclusions: Persistent decline in physical function affects mortality risk in ambulatory older men.
Keywords
Timed Up and Go, Mortality, Frailty transitions, Change in physical performance, Ambulatory older men

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Chicago
De Buyser, Stefanie, Mirko Petrovic, Youri Taes, Bruno Lapauw, Kaatje Toye, Jean Kaufman, and Stefan Goemaere. 2015. “Persistent Decline over 3 Years in Physical Function Predicts 15-year Mortality in Ambulatory Older Men.” In European Geriatric Medicine, ed. Jean-Pierre Michel, 6:S8–S8.
APA
De Buyser, S., Petrovic, M., Taes, Y., Lapauw, B., Toye, K., Kaufman, J., & Goemaere, S. (2015). Persistent decline over 3 years in physical function predicts 15-year mortality in ambulatory older men. In J.-P. Michel (Ed.), EUROPEAN GERIATRIC MEDICINE (Vol. 6, pp. S8–S8). Presented at the 11th International congress of the European Union Geriatric Medicine Society.
Vancouver
1.
De Buyser S, Petrovic M, Taes Y, Lapauw B, Toye K, Kaufman J, et al. Persistent decline over 3 years in physical function predicts 15-year mortality in ambulatory older men. In: Michel J-P, editor. EUROPEAN GERIATRIC MEDICINE. 2015. p. S8–S8.
MLA
De Buyser, Stefanie, Mirko Petrovic, Youri Taes, et al. “Persistent Decline over 3 Years in Physical Function Predicts 15-year Mortality in Ambulatory Older Men.” European Geriatric Medicine. Ed. Jean-Pierre Michel. Vol. 6. 2015. S8–S8. Print.
@inproceedings{6930576,
  abstract     = {Objectives: Physical function measurements can predict important adverse outcomes in older persons, but little is known about the predictive value of longitudinal changes in these measurements. This study evaluated the effects of transient and persistent decline over three years from baseline in physical function on 12 year mortality. 
Methods: This community-based cohort study included ambulatory men aged \ensuremath{\geq}71, living in the community of Merelbeke (municipality of Ghent, Belgium). Participants{\textquoteright} physical function and decline from baseline were assessed annually over three years using the following measurements and cut-off points: Timed Up and Go (2 sec), Chair Rise (1 sec), Balance (1 point), Grip strength (6kg), General Health (Short Form-36 item; 15 points), Physical Function (Short Form-36 item; 20 points) and Activities of Daily Living (ADL; Rapid Disability Rating Scale-2 questions; 2 points). Decline was considered persistent or transient based on whether the decline was still present at the end of year three. 
Results: Of 162 older men with complete annual physical function assessments from 1997 until 2000, 107 (66\%) died within the subsequent 12 years. Mortality risk increased with persistent decline in Timed Up and Go (HR=2.15, 95\%CI=1.24--3.73), Grip strength (HR=3.39, 95\% CI=1.45--7.93), Physical Function (HR=2.51, 95\%CI=1.43--4.41), General Health (HR=3.07, 95\%CI=1.69--5.60), and ADL score (HR=3.30, 95\%CI=1.43--7.63), compared with no decline. Decline in the last year in Chair Rise time (HR=2.63, 95\%CI=1.39--4.98) and Balance (HR=2.39, 95\%CI=1.10--5.18) also predicted death.
Conclusions: Persistent decline in physical function affects mortality risk in ambulatory older men.},
  author       = {De Buyser, Stefanie and Petrovic, Mirko and Taes, Youri and Lapauw, Bruno and Toye, Kaatje and Kaufman, Jean and Goemaere, Stefan},
  booktitle    = {EUROPEAN GERIATRIC MEDICINE},
  editor       = {Michel, Jean-Pierre},
  issn         = {1878-7649},
  keyword      = {Timed Up and Go,Mortality,Frailty transitions,Change in physical performance,Ambulatory older men},
  language     = {eng},
  location     = {Oslo, Norway},
  number       = {suppl. 1},
  pages        = {S8--S8},
  title        = {Persistent decline over 3 years in physical function predicts 15-year mortality in ambulatory older men},
  volume       = {6},
  year         = {2015},
}