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The FNIH-criteria for sarcopenia predict 15-year mortality in ambulatory older men

Stefanie De Buyser UGent, Mirko Petrovic UGent, Youri Taes, Kaatje Toye UGent, Jean Kaufman UGent, Bruno Lapauw UGent and Stefan Goemaere (2015) EUROPEAN GERIATRIC MEDICINE. 6(suppl. 1). p.S85-S86
abstract
Objectives: The Foundation for the National Institutes of Health [FNIH] Sarcopenia Project recently developed new criteria for diagnosis of weakness and low muscle mass in older adults. These criteria were associated with increased likelihood for incident mobility impairment. However, mortality risk patterns were inconsistent and further validation of their cut-off points in other populations seems needed (McLean et al., 2014 Journals of Gerontology). In this study, we aimed to evaluate the FNIH cut-off points for weakness and low muscle mass in a sample of community-dwelling older men in Belgium. Methods: This community-based cohort study included 200 ambulatory men aged ≥74, living in the community of Merelbeke (municipality of Ghent, Belgium). Grip strength was measured twice consecutively using a Jamar type dynamometer. Weakness was defined as low grip strength (<26kg) and low grip strength-to-body mass index[BMI] ratio (<1.00). Low muscle mass (dual-energy x-ray absorptiometry) was categorized as low appendicular lean mass[ALM] (<19.75kg) and low ALM-to-BMI ratio (<0.789). Results: Mean age was 78.5(±3.5) years. Combined weakness and low muscle mass was present in 4 to 9% of men, depending on the criteria applied. After 12 years of follow-up, 134 men (67%) had died. Low grip strength (HR=1.59,95%CI=1.06–2.28), low grip strength-to-BMI ratio (HR=1.65,95%CI=1.03–2.65) and low ALM-to-BMI ratio (HR=1.68,95%CI=1.18–2.41), but not low ALM, were associated with all-cause mortality in older community-dwelling men. Conclusions: These findings confirm the FNIH cut-off points for low grip strength and low ALM-to-BMI ratio as candidate criteria for clinically relevant weakness and low muscle mass in men.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
SOF frailty, Mortality, Ambulatory older men, FNIH sarcopenia
in
EUROPEAN GERIATRIC MEDICINE
Eur. Geriatr. Med.
editor
Jean-Pierre Michel
volume
6
issue
suppl. 1
issue title
Abstracts of the 11th international congress of the European Union Geriatric Medicine Society
pages
S85 - S86
conference name
11th International congress of the European Union Geriatric Medicine Society
conference location
Oslo, Norway
conference start
2015-09-16
conference end
2015-09-18
JCR category
GERIATRICS & GERONTOLOGY
JCR impact factor
1.326 (2015)
JCR rank
40/49 (2015)
JCR quartile
4 (2015)
ISSN
1878-7649
language
English
UGent publication?
yes
classification
C3
additional info
uploaded document is poster
copyright statement
I have retained and own the full copyright for this publication
id
6930399
handle
http://hdl.handle.net/1854/LU-6930399
date created
2015-09-15 10:43:25
date last changed
2016-12-19 15:36:59
@inproceedings{6930399,
  abstract     = {Objectives: The Foundation for the National Institutes of Health [FNIH] Sarcopenia Project recently developed new criteria for diagnosis of weakness and low muscle mass in older adults. These criteria were associated with increased likelihood for incident mobility impairment. However, mortality risk patterns were inconsistent and further validation of their cut-off points in other populations seems needed (McLean et al., 2014 Journals of Gerontology).
In this study, we aimed to evaluate the FNIH cut-off points for weakness and low muscle mass in a sample of community-dwelling older men in Belgium.
Methods: This community-based cohort study included 200 ambulatory men aged \ensuremath{\geq}74, living in the community of Merelbeke (municipality of Ghent, Belgium). Grip strength was measured twice consecutively using a Jamar type dynamometer. Weakness was defined as low grip strength ({\textlangle}26kg) and low grip strength-to-body mass index[BMI] ratio ({\textlangle}1.00). Low muscle mass (dual-energy x-ray absorptiometry) was categorized as low appendicular lean mass[ALM] ({\textlangle}19.75kg) and low ALM-to-BMI ratio ({\textlangle}0.789).
Results: Mean age was 78.5({\textpm}3.5) years. Combined weakness and low muscle mass was present in 4 to 9\% of men, depending on the criteria applied. After 12 years of follow-up, 134 men (67\%) had died. Low grip strength (HR=1.59,95\%CI=1.06--2.28), low grip strength-to-BMI ratio (HR=1.65,95\%CI=1.03--2.65) and low ALM-to-BMI ratio (HR=1.68,95\%CI=1.18--2.41), but not low ALM, were associated with all-cause mortality in older community-dwelling men.
Conclusions: These findings confirm the FNIH cut-off points for low grip strength and low ALM-to-BMI ratio as candidate criteria for clinically relevant weakness and low muscle mass in men.},
  author       = {De Buyser, Stefanie and Petrovic, Mirko and Taes, Youri and Toye, Kaatje and Kaufman, Jean and Lapauw, Bruno and Goemaere, Stefan},
  booktitle    = {EUROPEAN GERIATRIC MEDICINE},
  editor       = {Michel, Jean-Pierre},
  issn         = {1878-7649},
  keyword      = {SOF frailty,Mortality,Ambulatory older men,FNIH sarcopenia},
  language     = {eng},
  location     = {Oslo, Norway},
  number       = {suppl. 1},
  pages        = {S85--S86},
  title        = {The FNIH-criteria for sarcopenia predict 15-year mortality in ambulatory older men},
  volume       = {6},
  year         = {2015},
}

Chicago
De Buyser, Stefanie, Mirko Petrovic, Youri Taes, Kaatje Toye, Jean Kaufman, Bruno Lapauw, and Stefan Goemaere. 2015. “The FNIH-criteria for Sarcopenia Predict 15-year Mortality in Ambulatory Older Men.” In European Geriatric Medicine, ed. Jean-Pierre Michel, 6:S85–S86.
APA
De Buyser, S., Petrovic, M., Taes, Y., Toye, K., Kaufman, J., Lapauw, B., & Goemaere, S. (2015). The FNIH-criteria for sarcopenia predict 15-year mortality in ambulatory older men. In J.-P. Michel (Ed.), EUROPEAN GERIATRIC MEDICINE (Vol. 6, pp. S85–S86). Presented at the 11th International congress of the European Union Geriatric Medicine Society.
Vancouver
1.
De Buyser S, Petrovic M, Taes Y, Toye K, Kaufman J, Lapauw B, et al. The FNIH-criteria for sarcopenia predict 15-year mortality in ambulatory older men. In: Michel J-P, editor. EUROPEAN GERIATRIC MEDICINE. 2015. p. S85–S86.
MLA
De Buyser, Stefanie, Mirko Petrovic, Youri Taes, et al. “The FNIH-criteria for Sarcopenia Predict 15-year Mortality in Ambulatory Older Men.” European Geriatric Medicine. Ed. Jean-Pierre Michel. Vol. 6. 2015. S85–S86. Print.