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Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review

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Abstract
Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively absorbed from the gut into the circulation and transferred to the appropriate location within the body while still maintaining their bioactivity. One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium. The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins. Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds. However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins. In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.
Keywords
anthocyanins, metabolism, Caco-2 cells, intestinal absorption, COLON-CANCER CELLS, RED GRAPE JUICE, IN-VITRO, PHENOLIC-COMPOUNDS, EPITHELIAL-CELLS, HUMAN HEALTH, TRANSEPITHELIAL TRANSPORT, BILBERRY EXTRACT, PRESS-RESIDUE, BIOAVAILABILITY

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MLA
Kamiloglu, Senem et al. “Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells: a Review.” Ed. Maurizio Battino. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.9 (2015): 21555–21574. Print.
APA
Kamiloglu, S., Capanoglu, E., Grootaert, C., & Van Camp, J. (2015). Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review. (M. Battino, Ed.)INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16(9), 21555–21574.
Chicago author-date
Kamiloglu, Senem, Esra Capanoglu, Charlotte Grootaert, and John Van Camp. 2015. “Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells: a Review.” Ed. Maurizio Battino. International Journal of Molecular Sciences 16 (9): 21555–21574.
Chicago author-date (all authors)
Kamiloglu, Senem, Esra Capanoglu, Charlotte Grootaert, and John Van Camp. 2015. “Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells: a Review.” Ed. Maurizio Battino. International Journal of Molecular Sciences 16 (9): 21555–21574.
Vancouver
1.
Kamiloglu S, Capanoglu E, Grootaert C, Van Camp J. Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review. Battino M, editor. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015;16(9):21555–74.
IEEE
[1]
S. Kamiloglu, E. Capanoglu, C. Grootaert, and J. Van Camp, “Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review,” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 9, pp. 21555–21574, 2015.
@article{6929028,
  abstract     = {Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively absorbed from the gut into the circulation and transferred to the appropriate location within the body while still maintaining their bioactivity. One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium. The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins. Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds. However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins. In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.},
  author       = {Kamiloglu, Senem and Capanoglu, Esra and Grootaert, Charlotte and Van Camp, John},
  editor       = {Battino, Maurizio},
  issn         = {1422-0067},
  journal      = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
  keywords     = {anthocyanins,metabolism,Caco-2 cells,intestinal absorption,COLON-CANCER CELLS,RED GRAPE JUICE,IN-VITRO,PHENOLIC-COMPOUNDS,EPITHELIAL-CELLS,HUMAN HEALTH,TRANSEPITHELIAL TRANSPORT,BILBERRY EXTRACT,PRESS-RESIDUE,BIOAVAILABILITY},
  language     = {eng},
  number       = {9},
  pages        = {21555--21574},
  title        = {Anthocyanin absorption and metabolism by human intestinal Caco-2 cells: a review},
  url          = {http://dx.doi.org/10.3390/ijms160921555},
  volume       = {16},
  year         = {2015},
}

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