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Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area

(2016) CEREBRAL CORTEX. 26(5). p.2225-2241
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Abstract
The inferior frontal junction (IFJ) area, a small region in the posterior lateral prefrontal cortex (LPFC), has received increasing interest in recent years due to its central involvement in the control of action, attention, and memory. Yet, both its function and anatomy remain controversial. Here, we employed a meta-analytic parcellation of the left LPFC to show that the IFJ can be isolated based on its specific functional connections. A seed region, oriented along the left inferior frontal sulcus (IFS), was subdivided via cluster analyses of voxel-wise whole-brain co-activation patterns. The ensuing clusters were characterized by their unique connections, the functional profiles of associated experiments, and an independent topic mapping approach. A cluster at the posterior end of the IFS matched previous descriptions of the IFJ in location and extent and could be distinguished from a more caudal cluster involved in motor control, a more ventral cluster involved in linguistic processing, and 3 more rostral clusters involved in other aspects of cognitive control. Overall, our findings highlight that the IFJ constitutes a core functional unit within the frontal lobe and delineate its borders. Implications for the IFJ’s role in human cognition and the organizational principles of the frontal lobe are discussed.
Keywords
prefrontal cortex, inferior frontal junction, meta-analysis, cognitive control, SHORT-TERM-MEMORY, WORKING-MEMORY, HUMAN BRAIN, PARIETAL CORTEX, FUNCTIONAL CONNECTIVITY, NEUROIMAGING DATA, TOP-DOWN MODULATION, STIMULUS-DRIVEN ATTENTION, TASK-RELEVANT INFORMATION, COGNITIVE CONTROL NETWORK

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Citation

Please use this url to cite or link to this publication:

Chicago
Muhle-Karbe, Paul Simon, Jan Derrfuss, Maggie Lynn, Franz Xaver Neubert, Peter Fox, Marcel Brass, and Simon Eickhoff. 2016. “Co-activation-based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area.” Cerebral Cortex 26 (5): 2225–2241.
APA
Muhle-Karbe, P. S., Derrfuss, J., Lynn, M., Neubert, F. X., Fox, P., Brass, M., & Eickhoff, S. (2016). Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area. CEREBRAL CORTEX, 26(5), 2225–2241.
Vancouver
1.
Muhle-Karbe PS, Derrfuss J, Lynn M, Neubert FX, Fox P, Brass M, et al. Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area. CEREBRAL CORTEX. 2016;26(5):2225–41.
MLA
Muhle-Karbe, Paul Simon, Jan Derrfuss, Maggie Lynn, et al. “Co-activation-based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area.” CEREBRAL CORTEX 26.5 (2016): 2225–2241. Print.
@article{6928946,
  abstract     = {The inferior frontal junction (IFJ) area, a small region in the posterior lateral prefrontal cortex (LPFC), has received increasing interest in recent years due to its central involvement in the control of action, attention, and memory. Yet, both its function and anatomy remain controversial. Here, we employed a meta-analytic parcellation of the left LPFC to show that the IFJ can be isolated based on its specific functional connections. A seed region, oriented along the left inferior frontal sulcus (IFS), was subdivided via cluster analyses of voxel-wise whole-brain co-activation patterns. The ensuing clusters were characterized by their unique connections, the functional profiles of associated experiments, and an independent topic mapping approach. A cluster at the posterior end of the IFS matched previous descriptions of the IFJ in location and extent and could be distinguished from a more caudal cluster involved in motor control, a more ventral cluster involved in linguistic processing, and 3 more rostral clusters involved in other aspects of cognitive control. Overall, our findings highlight that the IFJ constitutes a core functional unit within the frontal lobe and delineate its borders. Implications for the IFJ{\textquoteright}s role in human cognition and the organizational principles of the frontal lobe are discussed.},
  author       = {Muhle-Karbe, Paul Simon and Derrfuss, Jan and Lynn, Maggie and Neubert, Franz Xaver and Fox, Peter and Brass, Marcel and Eickhoff, Simon},
  issn         = {1047-3211},
  journal      = {CEREBRAL CORTEX},
  keyword      = {prefrontal cortex,inferior frontal junction,meta-analysis,cognitive control,SHORT-TERM-MEMORY,WORKING-MEMORY,HUMAN BRAIN,PARIETAL CORTEX,FUNCTIONAL CONNECTIVITY,NEUROIMAGING DATA,TOP-DOWN MODULATION,STIMULUS-DRIVEN ATTENTION,TASK-RELEVANT INFORMATION,COGNITIVE CONTROL NETWORK},
  language     = {eng},
  number       = {5},
  pages        = {2225--2241},
  title        = {Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area},
  url          = {http://dx.doi.org/10.1093/cercor/bhv073},
  volume       = {26},
  year         = {2016},
}

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