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Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area

Paul Simon Muhle-Karbe UGent, Jan Derrfuss, Maggie Lynn, Franz Xaver Neubert, Peter Fox, Marcel Brass UGent and Simon Eickhoff (2016) CEREBRAL CORTEX. 26(5). p.2225-2241
abstract
The inferior frontal junction (IFJ) area, a small region in the posterior lateral prefrontal cortex (LPFC), has received increasing interest in recent years due to its central involvement in the control of action, attention, and memory. Yet, both its function and anatomy remain controversial. Here, we employed a meta-analytic parcellation of the left LPFC to show that the IFJ can be isolated based on its specific functional connections. A seed region, oriented along the left inferior frontal sulcus (IFS), was subdivided via cluster analyses of voxel-wise whole-brain co-activation patterns. The ensuing clusters were characterized by their unique connections, the functional profiles of associated experiments, and an independent topic mapping approach. A cluster at the posterior end of the IFS matched previous descriptions of the IFJ in location and extent and could be distinguished from a more caudal cluster involved in motor control, a more ventral cluster involved in linguistic processing, and 3 more rostral clusters involved in other aspects of cognitive control. Overall, our findings highlight that the IFJ constitutes a core functional unit within the frontal lobe and delineate its borders. Implications for the IFJ’s role in human cognition and the organizational principles of the frontal lobe are discussed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
prefrontal cortex, inferior frontal junction, meta-analysis, cognitive control, SHORT-TERM-MEMORY, WORKING-MEMORY, HUMAN BRAIN, PARIETAL CORTEX, FUNCTIONAL CONNECTIVITY, NEUROIMAGING DATA, TOP-DOWN MODULATION, STIMULUS-DRIVEN ATTENTION, TASK-RELEVANT INFORMATION, COGNITIVE CONTROL NETWORK
journal title
CEREBRAL CORTEX
volume
26
issue
5
pages
2225 - 2241
Web of Science type
Article
Web of Science id
000377469500032
JCR category
NEUROSCIENCES
JCR impact factor
6.559 (2016)
JCR rank
20/258 (2016)
JCR quartile
1 (2016)
ISSN
1047-3211
DOI
10.1093/cercor/bhv073
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
6928946
handle
http://hdl.handle.net/1854/LU-6928946
date created
2015-09-12 14:17:12
date last changed
2016-12-19 15:48:37
@article{6928946,
  abstract     = {The inferior frontal junction (IFJ) area, a small region in the posterior lateral prefrontal cortex (LPFC), has received increasing interest in recent years due to its central involvement in the control of action, attention, and memory. Yet, both its function and anatomy remain controversial. Here, we employed a meta-analytic parcellation of the left LPFC to show that the IFJ can be isolated based on its specific functional connections. A seed region, oriented along the left inferior frontal sulcus (IFS), was subdivided via cluster analyses of voxel-wise whole-brain co-activation patterns. The ensuing clusters were characterized by their unique connections, the functional profiles of associated experiments, and an independent topic mapping approach. A cluster at the posterior end of the IFS matched previous descriptions of the IFJ in location and extent and could be distinguished from a more caudal cluster involved in motor control, a more ventral cluster involved in linguistic processing, and 3 more rostral clusters involved in other aspects of cognitive control. Overall, our findings highlight that the IFJ constitutes a core functional unit within the frontal lobe and delineate its borders. Implications for the IFJ{\textquoteright}s role in human cognition and the organizational principles of the frontal lobe are discussed.},
  author       = {Muhle-Karbe, Paul Simon and Derrfuss, Jan and Lynn, Maggie and Neubert, Franz Xaver and Fox, Peter and Brass, Marcel and Eickhoff, Simon},
  issn         = {1047-3211},
  journal      = {CEREBRAL CORTEX},
  keyword      = {prefrontal cortex,inferior frontal junction,meta-analysis,cognitive control,SHORT-TERM-MEMORY,WORKING-MEMORY,HUMAN BRAIN,PARIETAL CORTEX,FUNCTIONAL CONNECTIVITY,NEUROIMAGING DATA,TOP-DOWN MODULATION,STIMULUS-DRIVEN ATTENTION,TASK-RELEVANT INFORMATION,COGNITIVE CONTROL NETWORK},
  language     = {eng},
  number       = {5},
  pages        = {2225--2241},
  title        = {Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area},
  url          = {http://dx.doi.org/10.1093/cercor/bhv073},
  volume       = {26},
  year         = {2016},
}

Chicago
Muhle-Karbe, Paul Simon, Jan Derrfuss, Maggie Lynn, Franz Xaver Neubert, Peter Fox, Marcel Brass, and Simon Eickhoff. 2016. “Co-activation-based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area.” Cerebral Cortex 26 (5): 2225–2241.
APA
Muhle-Karbe, P. S., Derrfuss, J., Lynn, M., Neubert, F. X., Fox, P., Brass, M., & Eickhoff, S. (2016). Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area. CEREBRAL CORTEX, 26(5), 2225–2241.
Vancouver
1.
Muhle-Karbe PS, Derrfuss J, Lynn M, Neubert FX, Fox P, Brass M, et al. Co-activation-based parcellation of the lateral prefrontal cortex delineates the inferior frontal junction area. CEREBRAL CORTEX. 2016;26(5):2225–41.
MLA
Muhle-Karbe, Paul Simon, Jan Derrfuss, Maggie Lynn, et al. “Co-activation-based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area.” CEREBRAL CORTEX 26.5 (2016): 2225–2241. Print.