Ghent University Academic Bibliography

Advanced

Vagal nerve stimulation: a 15-year survey of an established treatment modality in epilepsy surgery

Kristl Vonck UGent, Veerle De Herdt UGent and Paul Boon UGent (2009) Advances and technical standards in neurosurgery. In Advances and Technical Standards in Neurosurgery 34. p.111-146
abstract
Neurostimulation is an emerging treatment for neurological diseases. Electrical stimulation of the tenth cranial nerve or vagus nerve stimulation (VNS) has become a valuable option in the therapeutic armamentarium for patients with refractory epilepsy. It is indicated in patients with refractory epilepsy who are unsuitable candidates for epilepsy surgery or who have had insufficient benefit from such a treatment. Vagus nerve stimulation reduces seizure frequency with > 50% in 1/3 of patients and has a mild side effects profile. Research to elucidate the mechanism of action of vagus nerve stimulation has shown that effective stimulation in humans is primarily mediated by afferent vagal A- and B-fibers. Crucial brainstem and intracranial structures include the locus coeruleus, the nucleus of the solitary tract, the thalamus and limbic structures. Neurotransmitters playing a role may involve the major inhibitory neurotransmitter GABA but also serotoninergic and adrenergic systems. This manuscript reviews the clinical studies investigating efficacy and side effects in patients and the experimental studies aiming to elucidate the mechanims of action.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
book title
Advances and technical standards in neurosurgery
editor
JD Pickard, N Akalan, C Di Rocco, VV Dolenc, J Lobo Antunes, JJA Mooij, J Schramm and M Sindou
series title
Advances and Technical Standards in Neurosurgery
volume
34
pages
111 - 146
publisher
Springer
place of publication
Vienna, Austria
ISSN
0095-4829
ISBN
9783211787410
9783211787403
DOI
10.1007/978-3-211-78741-0_5
language
English
UGent publication?
yes
classification
B2
copyright statement
I have transferred the copyright for this publication to the publisher
id
692874
handle
http://hdl.handle.net/1854/LU-692874
date created
2009-06-12 11:08:18
date last changed
2014-04-29 16:41:36
@incollection{692874,
  abstract     = {Neurostimulation is an emerging treatment for neurological diseases. Electrical stimulation of the tenth cranial nerve or vagus nerve stimulation (VNS) has become a valuable option in the therapeutic armamentarium for patients with refractory epilepsy. It is indicated in patients with refractory epilepsy who are unsuitable candidates for epilepsy surgery or who have had insufficient benefit from such a treatment. Vagus nerve stimulation reduces seizure frequency with {\textrangle} 50\% in 1/3 of patients and has a mild side effects profile. Research to elucidate the mechanism of action of vagus nerve stimulation has shown that effective stimulation in humans is primarily mediated by afferent vagal A- and B-fibers. Crucial brainstem and intracranial structures include the locus coeruleus, the nucleus of the solitary tract, the thalamus and limbic structures. Neurotransmitters playing a role may involve the major inhibitory neurotransmitter GABA but also serotoninergic and adrenergic systems. This manuscript reviews the clinical studies investigating efficacy and side effects in patients and the experimental studies aiming to elucidate the mechanims of action.},
  author       = {Vonck, Kristl and De Herdt, Veerle and Boon, Paul},
  booktitle    = {Advances and technical standards in neurosurgery},
  editor       = {Pickard, JD and Akalan, N and Di Rocco, C and Dolenc, VV and Lobo Antunes, J and Mooij, JJA and Schramm, J and Sindou, M},
  isbn         = {9783211787410},
  issn         = {0095-4829},
  language     = {eng},
  pages        = {111--146},
  publisher    = {Springer},
  series       = {Advances and Technical Standards in Neurosurgery},
  title        = {Vagal nerve stimulation: a 15-year survey of an established treatment modality in epilepsy surgery},
  url          = {http://dx.doi.org/10.1007/978-3-211-78741-0\_5},
  volume       = {34},
  year         = {2009},
}

Chicago
Vonck, Kristl, Veerle De Herdt, and Paul Boon. 2009. “Vagal Nerve Stimulation: a 15-year Survey of an Established Treatment Modality in Epilepsy Surgery.” In Advances and Technical Standards in Neurosurgery, ed. JD Pickard, N Akalan, C Di Rocco, VV Dolenc, J Lobo Antunes, JJA Mooij, J Schramm, and M Sindou, 34:111–146. Vienna, Austria: Springer.
APA
Vonck, K., De Herdt, V., & Boon, P. (2009). Vagal nerve stimulation: a 15-year survey of an established treatment modality in epilepsy surgery. In J. Pickard, N. Akalan, C. Di Rocco, V. Dolenc, J. Lobo Antunes, J. Mooij, J. Schramm, et al. (Eds.), Advances and technical standards in neurosurgery (Vol. 34, pp. 111–146). Vienna, Austria: Springer.
Vancouver
1.
Vonck K, De Herdt V, Boon P. Vagal nerve stimulation: a 15-year survey of an established treatment modality in epilepsy surgery. In: Pickard J, Akalan N, Di Rocco C, Dolenc V, Lobo Antunes J, Mooij J, et al., editors. Advances and technical standards in neurosurgery. Vienna, Austria: Springer; 2009. p. 111–46.
MLA
Vonck, Kristl, Veerle De Herdt, and Paul Boon. “Vagal Nerve Stimulation: a 15-year Survey of an Established Treatment Modality in Epilepsy Surgery.” Advances and Technical Standards in Neurosurgery. Ed. JD Pickard et al. Vol. 34. Vienna, Austria: Springer, 2009. 111–146. Print.