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Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age

Nathalie Porters (UGent) , Hilde De Rooster (UGent) , Christel Moons (UGent) , Luc Duchateau (UGent) , Klara Goethals (UGent) , Tim Bosmans (UGent) and Ingeborgh Polis (UGent)
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Abstract
Anaesthetic and analgesic effects of three different injectable anaesthetic combinations for prepubertal gonadectomy (PPG) in cats were studied. One anaesthetic protocol was compared with a similar one for gonadectomy at traditional age (TAG). Kittens were randomly assigned to PPG or TAG. For PPG, three different protocols were compared: (1) intramuscular (IM) administration of 60 g/kg dexmedetomidine plus 20 g/kg buprenorphine followed by an IM injection of the anaesthetic agent (20mg/kg ketamine) (DB-IM protocol); (2) oral transmucosal (OTM) administration of 80 g/kg dexmedetomidine plus 20g/kg buprenorphine followed by an IM injection of 20mg/kg ketamine combined with 20 mu g/kg dexmedetomidine (DB-OTM protocol); (3) IM injection of a 40g/kg medetomidine-20g/kg buprenorphine-20mg/kg ketamine combination (MBK-IM protocol). For TAG, a DB-IM protocol was used, but with different doses for dexmedetomidine (40g/kg) and ketamine (5mg/kg). All cats (PPG and TAG) received a non-steroidal anti-inflammatory before surgery. Anaesthetic and analgesic effects were assessed pre- and postoperatively (until 6h). Cumulative logit, linear and logistic regression models were used for statistical analysis. Compared with the DB-OTM protocol, the DB-IM and MBK-IM protocols provided better anaesthesia with fewer adverse effects in PPG cats. Postoperative pain was not significantly different between anaesthetic protocols. PPG and TAG cats anaesthetised with the two DB-IM protocols differed significantly only for sedation and pain scores, but sedation and pain scores were generally low. Although there were no anaesthesia-related mortalities in the present study and all anaesthetic protocols for PPG in cats provided a surgical plane of anaesthesia and analgesia up to 6h postoperatively, our findings were in favour of the intramuscular (DB-IM and MBK-IM) protocols.
Keywords
POSTOPERATIVE ANALGESIA, NEUTERING 6-WEEK-OLD, FELINE OVARIOHYSTERECTOMY, ORAL TRANSMUCOSAL, BUPRENORPHINE, DEXMEDETOMIDINE, CARPROFEN, PAIN, MEDETOMIDINE, MANAGEMENT

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Chicago
Porters, Nathalie, Hilde De Rooster, Christel Moons, Luc Duchateau, Klara Goethals, Tim Bosmans, and Ingeborgh Polis. 2015. “Prepubertal Gonadectomy in Cats: Different Injectable Anaesthetic Combinations and Comparison with Gonadectomy at Traditional Age.” Journal of Feline Medicine and Surgery 17 (6): 458–467.
APA
Porters, N., De Rooster, H., Moons, C., Duchateau, L., Goethals, K., Bosmans, T., & Polis, I. (2015). Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age. JOURNAL OF FELINE MEDICINE AND SURGERY, 17(6), 458–467.
Vancouver
1.
Porters N, De Rooster H, Moons C, Duchateau L, Goethals K, Bosmans T, et al. Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age. JOURNAL OF FELINE MEDICINE AND SURGERY. 2015;17(6):458–67.
MLA
Porters, Nathalie, Hilde De Rooster, Christel Moons, et al. “Prepubertal Gonadectomy in Cats: Different Injectable Anaesthetic Combinations and Comparison with Gonadectomy at Traditional Age.” JOURNAL OF FELINE MEDICINE AND SURGERY 17.6 (2015): 458–467. Print.
@article{6923944,
  abstract     = {Anaesthetic and analgesic effects of three different injectable anaesthetic combinations for prepubertal gonadectomy (PPG) in cats were studied. One anaesthetic protocol was compared with a similar one for gonadectomy at traditional age (TAG). Kittens were randomly assigned to PPG or TAG. For PPG, three different protocols were compared: (1) intramuscular (IM) administration of 60 g/kg dexmedetomidine plus 20 g/kg buprenorphine followed by an IM injection of the anaesthetic agent (20mg/kg ketamine) (DB-IM protocol); (2) oral transmucosal (OTM) administration of 80 g/kg dexmedetomidine plus 20g/kg buprenorphine followed by an IM injection of 20mg/kg ketamine combined with 20 mu g/kg dexmedetomidine (DB-OTM protocol); (3) IM injection of a 40g/kg medetomidine-20g/kg buprenorphine-20mg/kg ketamine combination (MBK-IM protocol). For TAG, a DB-IM protocol was used, but with different doses for dexmedetomidine (40g/kg) and ketamine (5mg/kg). All cats (PPG and TAG) received a non-steroidal anti-inflammatory before surgery. Anaesthetic and analgesic effects were assessed pre- and postoperatively (until 6h). Cumulative logit, linear and logistic regression models were used for statistical analysis. Compared with the DB-OTM protocol, the DB-IM and MBK-IM protocols provided better anaesthesia with fewer adverse effects in PPG cats. Postoperative pain was not significantly different between anaesthetic protocols. PPG and TAG cats anaesthetised with the two DB-IM protocols differed significantly only for sedation and pain scores, but sedation and pain scores were generally low. Although there were no anaesthesia-related mortalities in the present study and all anaesthetic protocols for PPG in cats provided a surgical plane of anaesthesia and analgesia up to 6h postoperatively, our findings were in favour of the intramuscular (DB-IM and MBK-IM) protocols.},
  author       = {Porters, Nathalie and De Rooster, Hilde and Moons, Christel and Duchateau, Luc and Goethals, Klara and Bosmans, Tim and Polis, Ingeborgh},
  issn         = {1098-612X},
  journal      = {JOURNAL OF FELINE MEDICINE AND SURGERY},
  language     = {eng},
  number       = {6},
  pages        = {458--467},
  title        = {Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age},
  url          = {http://dx.doi.org/10.1177/1098612X14546919},
  volume       = {17},
  year         = {2015},
}

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