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Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ3 integrin

(2014) ANNALS OF SURGICAL ONCOLOGY. 21(6). p.2097-2104
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Abstract
The recent introduction of biological anticancer therapy has renewed the interest in functional imaging of tumor-associated angiogenesis (TAA) as a tool to monitor early therapy response. The present study evaluated imaging of TAA using P1227, a novel, small molecular magnetic resonance imaging (MRI) probe targeting alpha(v)beta(3) integrin. HT29 human colorectal cancers were grown in athymic mice. Dynamic MRI was performed using a three-dimensional VIBE sequence up to 110 min after injection of P1227 or gadolinium-tetraazacyclododecane tetraacetic acid (Gd-DOTA). Specificity was assessed by using P1227 1 h after intravenous administration of the alpha(v)beta(3) inhibitor cilengitide. Regions of interest were drawn encompassing the tumor rim and normal muscle. Imaging data were compared with microvessel density and alpha(v)beta(3) expression. Using P1227, specific enhancement of the angiogenic tumor rim, but not of normal muscle, was observed, whereas Gd-DOTA enhanced tumor and normal muscle. After administering cilengitide, enhancement with P1227, but not with DOTA, was significantly suppressed during the first 20 min. When using P1227, a significant correlation was observed between normalized enhancement of the tumor rim and immunohistochemical alpha(v)beta(3) integrin expression. Molecular MRI using a small monogadolinated tracer targeting alpha(v)beta(3) integrin and moderate magnetic field strength holds promise in assessing colorectal TAA.
Keywords
IN-VIVO, NANOPARTICLE, RGD PEPTIDES, ALPHA-V-BETA-3 EXPRESSION, COLON-CARCINOMA CELLS, ADHESION, MODEL, RADIOTHERAPY, VASCULATURE, DELIVERY

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MLA
DEBERGH, ISABELLE et al. “Molecular Imaging of Tumor-associated Angiogenesis Using a Novel Magnetic Resonance Imaging Contrast Agent Targeting Αvβ3 Integrin.” ANNALS OF SURGICAL ONCOLOGY 21.6 (2014): 2097–2104. Print.
APA
DEBERGH, I., Van Damme, N., De Naeyer, D., Smeets, P., Demetter, P., Robert, P., Carme, S., et al. (2014). Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ3 integrin. ANNALS OF SURGICAL ONCOLOGY, 21(6), 2097–2104.
Chicago author-date
DEBERGH, ISABELLE, Nancy Van Damme, Dieter De Naeyer, Peter Smeets, Pieter Demetter, Philippe Robert, Sabin Carme, Piet Pattyn, and Wim Ceelen. 2014. “Molecular Imaging of Tumor-associated Angiogenesis Using a Novel Magnetic Resonance Imaging Contrast Agent Targeting Αvβ3 Integrin.” Annals of Surgical Oncology 21 (6): 2097–2104.
Chicago author-date (all authors)
DEBERGH, ISABELLE, Nancy Van Damme, Dieter De Naeyer, Peter Smeets, Pieter Demetter, Philippe Robert, Sabin Carme, Piet Pattyn, and Wim Ceelen. 2014. “Molecular Imaging of Tumor-associated Angiogenesis Using a Novel Magnetic Resonance Imaging Contrast Agent Targeting Αvβ3 Integrin.” Annals of Surgical Oncology 21 (6): 2097–2104.
Vancouver
1.
DEBERGH I, Van Damme N, De Naeyer D, Smeets P, Demetter P, Robert P, et al. Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ3 integrin. ANNALS OF SURGICAL ONCOLOGY. 2014;21(6):2097–104.
IEEE
[1]
I. DEBERGH et al., “Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ3 integrin,” ANNALS OF SURGICAL ONCOLOGY, vol. 21, no. 6, pp. 2097–2104, 2014.
@article{6914741,
  abstract     = {The recent introduction of biological anticancer therapy has renewed the interest in functional imaging of tumor-associated angiogenesis (TAA) as a tool to monitor early therapy response. The present study evaluated imaging of TAA using P1227, a novel, small molecular magnetic resonance imaging (MRI) probe targeting alpha(v)beta(3) integrin. 
HT29 human colorectal cancers were grown in athymic mice. Dynamic MRI was performed using a three-dimensional VIBE sequence up to 110 min after injection of P1227 or gadolinium-tetraazacyclododecane tetraacetic acid (Gd-DOTA). Specificity was assessed by using P1227 1 h after intravenous administration of the alpha(v)beta(3) inhibitor cilengitide. Regions of interest were drawn encompassing the tumor rim and normal muscle. Imaging data were compared with microvessel density and alpha(v)beta(3) expression. 
Using P1227, specific enhancement of the angiogenic tumor rim, but not of normal muscle, was observed, whereas Gd-DOTA enhanced tumor and normal muscle. After administering cilengitide, enhancement with P1227, but not with DOTA, was significantly suppressed during the first 20 min. When using P1227, a significant correlation was observed between normalized enhancement of the tumor rim and immunohistochemical alpha(v)beta(3) integrin expression. 
Molecular MRI using a small monogadolinated tracer targeting alpha(v)beta(3) integrin and moderate magnetic field strength holds promise in assessing colorectal TAA.},
  author       = {DEBERGH, ISABELLE and Van Damme, Nancy and De Naeyer, Dieter and Smeets, Peter and Demetter, Pieter and Robert, Philippe and Carme, Sabin and Pattyn, Piet and Ceelen, Wim},
  issn         = {1068-9265},
  journal      = {ANNALS OF SURGICAL ONCOLOGY},
  keywords     = {IN-VIVO,NANOPARTICLE,RGD PEPTIDES,ALPHA-V-BETA-3 EXPRESSION,COLON-CARCINOMA CELLS,ADHESION,MODEL,RADIOTHERAPY,VASCULATURE,DELIVERY},
  language     = {eng},
  number       = {6},
  pages        = {2097--2104},
  title        = {Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ3 integrin},
  url          = {http://dx.doi.org/10.1245/s10434-013-3444-1},
  volume       = {21},
  year         = {2014},
}

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