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Functional MRI during hippocampal deep brain stimulation in the healthy rat brain

Nathalie Van Den Berge, Christian Vanhove UGent, Benedicte Descamps UGent, Ine Dauwe UGent, Pieter van Mierlo UGent, Kristl Vonck UGent, Vincent Keereman, Robrecht Raedt UGent, Paul Boon UGent and Roel Van Holen UGent (2015) PLOS ONE. 10(7).
abstract
Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume. In order to visualize BOLD responses induced by DBS, we have developed an MRI-compatible electrode and an acquisition protocol to perform DBS during BOLD fMRI. In this study, we investigate whether DBS during fMRI is valuable to study local and whole-brain effects of hippocampal DBS and to investigate the changes induced by different stimulation intensities. Seven rats were stereotactically implanted with a custom-made MRI-compatible DBS-electrode in the right hippocampus. High frequency Poisson distributed stimulation was applied using a block-design paradigm. Data were processed by means of Independent Component Analysis. Clusters were considered significant when p-values were <0.05 after correction for multiple comparisons. Our data indicate that real-time hippocampal DBS evokes a bilateral BOLD response in hippocampal and other mesolimbic structures, depending on the applied stimulation intensity. We conclude that simultaneous DBS and fMRI can be used to detect local and whole-brain responses to circuit activation with different stimulation intensities, making this technique potentially powerful for exploration of cerebral changes in response to DBS for both preclinical and clinical DBS.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BOLD RESPONSE, FMRI, SEIZURES, CORTEX, SAFETY, PARKINSON-DISEASE, PERFORANT PATHWAY, ELECTRICAL-STIMULATION, TEMPORAL-LOBE EPILEPSY, INDEPENDENT COMPONENT ANALYSIS
journal title
PLOS ONE
PLoS One
volume
10
issue
7
article number
e0133245
pages
20 pages
Web of Science type
Article
Web of Science id
000358546400068
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
3.057 (2015)
JCR rank
11/63 (2015)
JCR quartile
1 (2015)
ISSN
1932-6203
DOI
10.1371/journal.pone.0133245
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
6913389
handle
http://hdl.handle.net/1854/LU-6913389
date created
2015-08-24 15:07:45
date last changed
2016-12-21 15:42:10
@article{6913389,
  abstract     = {Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume. In order to visualize BOLD responses induced by DBS, we have developed an MRI-compatible electrode and an acquisition protocol to perform DBS during BOLD fMRI. In this study, we investigate whether DBS during fMRI is valuable to study local and whole-brain effects of hippocampal DBS and to investigate the changes induced by different stimulation intensities. Seven rats were stereotactically implanted with a custom-made MRI-compatible DBS-electrode in the right hippocampus. High frequency Poisson distributed stimulation was applied using a block-design paradigm. Data were processed by means of Independent Component Analysis. Clusters were considered significant when p-values were {\textlangle}0.05 after correction for multiple comparisons. Our data indicate that real-time hippocampal DBS evokes a bilateral BOLD response in hippocampal and other mesolimbic structures, depending on the applied stimulation intensity. We conclude that simultaneous DBS and fMRI can be used to detect local and whole-brain responses to circuit activation with different stimulation intensities, making this technique potentially powerful for exploration of cerebral changes in response to DBS for both preclinical and clinical DBS.},
  articleno    = {e0133245},
  author       = {Van Den Berge, Nathalie and Vanhove, Christian and Descamps, Benedicte and Dauwe, Ine and van Mierlo, Pieter and Vonck, Kristl and Keereman, Vincent and Raedt, Robrecht and Boon, Paul and Van Holen, Roel},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {BOLD RESPONSE,FMRI,SEIZURES,CORTEX,SAFETY,PARKINSON-DISEASE,PERFORANT PATHWAY,ELECTRICAL-STIMULATION,TEMPORAL-LOBE EPILEPSY,INDEPENDENT COMPONENT ANALYSIS},
  language     = {eng},
  number       = {7},
  pages        = {20},
  title        = {Functional MRI during hippocampal deep brain stimulation in the healthy rat brain},
  url          = {http://dx.doi.org/10.1371/journal.pone.0133245},
  volume       = {10},
  year         = {2015},
}

Chicago
Van Den Berge, Nathalie, Christian Vanhove, Benedicte Descamps, INE DAUWE, Pieter van Mierlo, Kristl Vonck, Vincent Keereman, Robrecht Raedt, Paul Boon, and Roel Van Holen. 2015. “Functional MRI During Hippocampal Deep Brain Stimulation in the Healthy Rat Brain.” Plos One 10 (7).
APA
Van Den Berge, N., Vanhove, C., Descamps, B., DAUWE, I., van Mierlo, P., Vonck, K., Keereman, V., et al. (2015). Functional MRI during hippocampal deep brain stimulation in the healthy rat brain. PLOS ONE, 10(7).
Vancouver
1.
Van Den Berge N, Vanhove C, Descamps B, DAUWE I, van Mierlo P, Vonck K, et al. Functional MRI during hippocampal deep brain stimulation in the healthy rat brain. PLOS ONE. 2015;10(7).
MLA
Van Den Berge, Nathalie, Christian Vanhove, Benedicte Descamps, et al. “Functional MRI During Hippocampal Deep Brain Stimulation in the Healthy Rat Brain.” PLOS ONE 10.7 (2015): n. pag. Print.