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Intramuscular hepatitis B immunoglobulins for reinfection control after liver transplantation: a cost-saving alternative

Eva Hulstaert (UGent) , Xavier Verhelst (UGent) , Anja Geerts (UGent) and Hans Van Vlierberghe (UGent)
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Abstract
AIM: We explore the effectiveness and cost-effectiveness of intramuscular versus intravenous hepatitis B immunoglobulins (HBIG-IV vs HBIG-IM) to prevent reinfection with the hepatitis B virus after orthotopic liver transplantation. PATIENTS & METHODS: Overall, 14 patients had orthotopic liver transplantation in 2003-2013 at Ghent University Hospital for HBV-related liver disease. On average 32 months after transplantation patients switched from high-dose HBIG-IV to low-dose HBIG-IM, always in combination with a nucleos(t)ide analog. RESULTS: Seven patients were switched so far. No significant differences between HBIG-IV and HBIG-IM were found in HBsAg and hepatitis B virus-DNA. CONCLUSION: Switching patients from HBIG-IV to HBIG-IM can be done safely if well monitored. Net yearly savings for the healthcare payer were €5000 for each patient switched to HBIG-IM.
Keywords
comparative effectiveness, liver transplantation, hepatitis B, hepatitis B immunoglobulins, IMMUNE GLOBULIN, SURFACE-ANTIGEN, VIRUS INFECTION, PROPHYLAXIS, RECURRENCE, LAMIVUDINE, PREVENTION, MANAGEMENT, IMPACT, SAFE

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MLA
Hulstaert, Eva et al. “Intramuscular Hepatitis B Immunoglobulins for Reinfection Control After Liver Transplantation: a Cost-saving Alternative.” JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH 4.3 (2015): 259–265. Print.
APA
Hulstaert, E., Verhelst, X., Geerts, A., & Van Vlierberghe, H. (2015). Intramuscular hepatitis B immunoglobulins for reinfection control after liver transplantation: a cost-saving alternative. JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 4(3), 259–265.
Chicago author-date
Hulstaert, Eva, Xavier Verhelst, Anja Geerts, and Hans Van Vlierberghe. 2015. “Intramuscular Hepatitis B Immunoglobulins for Reinfection Control After Liver Transplantation: a Cost-saving Alternative.” Journal of Comparative Effectiveness Research 4 (3): 259–265.
Chicago author-date (all authors)
Hulstaert, Eva, Xavier Verhelst, Anja Geerts, and Hans Van Vlierberghe. 2015. “Intramuscular Hepatitis B Immunoglobulins for Reinfection Control After Liver Transplantation: a Cost-saving Alternative.” Journal of Comparative Effectiveness Research 4 (3): 259–265.
Vancouver
1.
Hulstaert E, Verhelst X, Geerts A, Van Vlierberghe H. Intramuscular hepatitis B immunoglobulins for reinfection control after liver transplantation: a cost-saving alternative. JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH. 2015;4(3):259–65.
IEEE
[1]
E. Hulstaert, X. Verhelst, A. Geerts, and H. Van Vlierberghe, “Intramuscular hepatitis B immunoglobulins for reinfection control after liver transplantation: a cost-saving alternative,” JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, vol. 4, no. 3, pp. 259–265, 2015.
@article{6912182,
  abstract     = {AIM: We explore the effectiveness and cost-effectiveness of intramuscular versus intravenous hepatitis B immunoglobulins (HBIG-IV vs HBIG-IM) to prevent reinfection with the hepatitis B virus after orthotopic liver transplantation.
PATIENTS & METHODS: Overall, 14 patients had orthotopic liver transplantation in 2003-2013 at Ghent University Hospital for HBV-related liver disease. On average 32 months after transplantation patients switched from high-dose HBIG-IV to low-dose HBIG-IM, always in combination with a nucleos(t)ide analog.
RESULTS: Seven patients were switched so far. No significant differences between HBIG-IV and HBIG-IM were found in HBsAg and hepatitis B virus-DNA.
CONCLUSION: Switching patients from HBIG-IV to HBIG-IM can be done safely if well monitored. Net yearly savings for the healthcare payer were €5000 for each patient switched to HBIG-IM.},
  author       = {Hulstaert, Eva and Verhelst, Xavier and Geerts, Anja and Van Vlierberghe, Hans},
  issn         = {2042-6305},
  journal      = {JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH},
  keywords     = {comparative effectiveness,liver transplantation,hepatitis B,hepatitis B immunoglobulins,IMMUNE GLOBULIN,SURFACE-ANTIGEN,VIRUS INFECTION,PROPHYLAXIS,RECURRENCE,LAMIVUDINE,PREVENTION,MANAGEMENT,IMPACT,SAFE},
  language     = {eng},
  number       = {3},
  pages        = {259--265},
  title        = {Intramuscular hepatitis B immunoglobulins for reinfection control after liver transplantation: a cost-saving alternative},
  url          = {http://dx.doi.org/10.2217/cer.15.4},
  volume       = {4},
  year         = {2015},
}

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