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Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis

(2014) SCIENCE. 344(6182). p.380-386
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Abstract
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/ chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
Keywords
PERITROPHIC MATRIX, IMMUNE-RESPONSES, AQUAPORINS, PROTEINS, DIPTERA, FLIES

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MLA
Watanabe, Junichi et al. “Genome Sequence of the Tsetse Fly (Glossina Morsitans): Vector of African Trypanosomiasis.” SCIENCE 344.6182 (2014): 380–386. Print.
APA
Watanabe, J., Hattori, M., Berriman, M., Lehane, M. J., Hall, N., Solano, P., Aksoy, S., et al. (2014). Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. SCIENCE, 344(6182), 380–386.
Chicago author-date
Watanabe, Junichi, Masahira Hattori, Matthew Berriman, Michael J Lehane, Neil Hall, Philippe Solano, Serap Aksoy, et al. 2014. “Genome Sequence of the Tsetse Fly (Glossina Morsitans): Vector of African Trypanosomiasis.” Science 344 (6182): 380–386.
Chicago author-date (all authors)
Watanabe, Junichi, Masahira Hattori, Matthew Berriman, Michael J Lehane, Neil Hall, Philippe Solano, Serap Aksoy, Winston Hide, Yeya Toure, Geoffrey M Attardo, Alistair C Darby, Atsushi Toyoda, Christiane Hertz-Fowler, Denis M Larkin, James A Cotton, Junichi Watanabe, Mandy J Sanders, Martin T Swain, Masahira Hattori, Matthew Berriman, Michael A Quail, Noboru Inoue, Sophie Ravel, Todd D Taylor, Tulika P Srivastava, Vineet Sharma, Wesley Warren, Richard K Wilson, Yutaka Suzuki, Daniel Lawson, Daniel ST Hughes, Karyn Megy, Daniel K Masiga, Paul O Mireji, Geoffrey M Attardo, Imma A Hansen, Jan Van Den Abbeele, Joshua B Benoit, Kostas Bourtzis, Michael J Lehane, Serap Aksoy, Daniel K Masiga, George FO Obiero, Hugh M Robertson, Jeffery W Jones, Jing-Jiang Zhou, Linda M Field, Markus Friedrich, Paul O Mireji, Steven RG Nyanjom, Erich L Telleria, Guy Caljon, Jose MC Ribeiro, Alvaro Acosta-Serrano, Joshua B Benoit, Cher-Pheng Ooi, Clair Rose, David P Price, Lee R Haines, Michael J Lehane, Alan Christoffels, Cheolho Sim, Daphne QD Pham, David L Denlinger, Dawn L Geiser, Irene A Omedo, Joshua B Benoit, Joy J Winzerling, Justin T Peyton, Kevin K Marucha, Mario Jonas, Megan E Meuti, Neil D Rawlings, Paul O Mireji, Qirui Zhang, Rosaline W Macharia, Veronika Michalkova, Zahra Jalali Sefid Dashti, Aaron A Baumann, Gerd Gaede, Heather G Marco, Immo A Hansen, Jelle Caers, Liliane Schoofs, Michael A Riehle, Wanqi Hu, Zhijian Tu, Aaron M Tarone, Anna R Malacrida, Caleb K Kibet, Joshua B Benoit, Francesca Scolari, Geoffrey M Attardo, Jacobus JO Koekemoer, Judith Willis, Ludvik M Gomulski, Marco Falchetto, Maxwell J Scott, Shuhua Fu, Sing-Hoi Sze, Thiago Luiz, Brian Weiss, Deirdre P Walshe, Jingwen Wang, Joshua B Benoit, Geoffrey M Attardo, Mark Wamalwa, Sarah Mwangi, Serap Aksoy, Urvashi N Ramphul, Anna K Snyder, Corey L Brelsfoard, Gavin H Thomas, George Tsiamis, Kostas Bourtzis, Peter Arensburger, Rita VM Rio, Sandy J Macdonald, Sumir Panji, Adele Kruger, Alan Christoffels, Alia Benkahla, Apollo SP Balyeidhusa, Atway Msangi, Cher-Pheng Ooi, Chinyere K Okoro, Daniel K Masiga, Dawn Stephens, Deirdre P Walshe, Eleanor J Stanley, Feziwe Mpondo, Florence Wamwiri, Furaha Mramba, Geoffrey M Attardo, Geoffrey Siwo, George FO Obiero, George Githinji, Gordon Harkins, Grace Murilla, Heikki Lehvaeslaiho, Imna Malele, Jacobus JO Koekemoer, Joanna E Auma, Johnson K Kinyua, Johnson Ouma, Junichi Watanabe, Karyn Megy, Loyce Okedi, Lucien Manga, Mario Jonas, Mark Wamalwa, Martin Aslett, Mathurin Koffi, Matthew Berriman, Michael J Lehane, Michael W Gaunt, Mmule Makgamathe, Neil Hall, Nicola Mulder, Oliver Manangwa, Patrick P Abila, Patrick Wincker, Paul O Mireji, Richard Gregory, Rita VM Rio, Rosemary Bateta, Ryuichi Sakate, Serap Aksoy, Sheila Ommeh, Stella Lehane, Steven RG Nyanjom, Tadashi Imanishi, Todd D Taylor, Victor C Osamor, Vineet Sharma, Winston Hide, Yoshihiro Kawahara, and Joshua B Benoit. 2014. “Genome Sequence of the Tsetse Fly (Glossina Morsitans): Vector of African Trypanosomiasis.” Science 344 (6182): 380–386.
Vancouver
1.
Watanabe J, Hattori M, Berriman M, Lehane MJ, Hall N, Solano P, et al. Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. SCIENCE. 2014;344(6182):380–6.
IEEE
[1]
J. Watanabe et al., “Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis,” SCIENCE, vol. 344, no. 6182, pp. 380–386, 2014.
@article{6905198,
  abstract     = {{Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/ chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.}},
  author       = {{Watanabe, Junichi and Hattori, Masahira and Berriman, Matthew and Lehane, Michael J and Hall, Neil and Solano, Philippe and Aksoy, Serap and Hide, Winston and Toure, Yeya and Attardo, Geoffrey M and Darby, Alistair C and Toyoda, Atsushi and Hertz-Fowler, Christiane and Larkin, Denis M and Cotton, James A and Watanabe, Junichi and Sanders, Mandy J and Swain, Martin T and Hattori, Masahira and Berriman, Matthew and Quail, Michael A and Inoue, Noboru and Ravel, Sophie and Taylor, Todd D and Srivastava, Tulika P and Sharma, Vineet and Warren, Wesley and Wilson, Richard K and Suzuki, Yutaka and Lawson, Daniel and Hughes, Daniel ST and Megy, Karyn and Masiga, Daniel K and Mireji, Paul O and Attardo, Geoffrey M and Hansen, Imma A and Van Den Abbeele, Jan and Benoit, Joshua B and Bourtzis, Kostas and Lehane, Michael J and Aksoy, Serap and Masiga, Daniel K and Obiero, George FO and Robertson, Hugh M and Jones, Jeffery W and Zhou, Jing-Jiang and Field, Linda M and Friedrich, Markus and Mireji, Paul O and Nyanjom, Steven RG and Telleria, Erich L and Caljon, Guy and Ribeiro, Jose MC and Acosta-Serrano, Alvaro and Benoit, Joshua B and Ooi, Cher-Pheng and Rose, Clair and Price, David P and Haines, Lee R and Lehane, Michael J and Christoffels, Alan and Sim, Cheolho and Pham, Daphne QD and Denlinger, David L and Geiser, Dawn L and Omedo, Irene A and Benoit, Joshua B and Winzerling, Joy J and Peyton, Justin T and Marucha, Kevin K and Jonas, Mario and Meuti, Megan E and Rawlings, Neil D and Mireji, Paul O and Zhang, Qirui and Macharia, Rosaline W and Michalkova, Veronika and Dashti, Zahra Jalali Sefid and Baumann, Aaron A and Gaede, Gerd and Marco, Heather G and Hansen, Immo A and Caers, Jelle and Schoofs, Liliane and Riehle, Michael A and Hu, Wanqi and Tu, Zhijian and Tarone, Aaron M and Malacrida, Anna R and Kibet, Caleb K and Benoit, Joshua B and Scolari, Francesca and Attardo, Geoffrey M and Koekemoer, Jacobus JO and Willis, Judith and Gomulski, Ludvik M and Falchetto, Marco and Scott, Maxwell J and Fu, Shuhua and Sze, Sing-Hoi and Luiz, Thiago and Weiss, Brian and Walshe, Deirdre P and Wang, Jingwen and Benoit, Joshua B and Attardo, Geoffrey M and Wamalwa, Mark and Mwangi, Sarah and Aksoy, Serap and Ramphul, Urvashi N and Snyder, Anna K and Brelsfoard, Corey L and Thomas, Gavin H and Tsiamis, George and Bourtzis, Kostas and Arensburger, Peter and Rio, Rita VM and Macdonald, Sandy J and Panji, Sumir and Kruger, Adele and Christoffels, Alan and Benkahla, Alia and Balyeidhusa, Apollo SP and Msangi, Atway and Ooi, Cher-Pheng and Okoro, Chinyere K and Masiga, Daniel K and Stephens, Dawn and Walshe, Deirdre P and Stanley, Eleanor J and Mpondo, Feziwe and Wamwiri, Florence and Mramba, Furaha and Attardo, Geoffrey M and Siwo, Geoffrey and Obiero, George FO and Githinji, George and Harkins, Gordon and Murilla, Grace and Lehvaeslaiho, Heikki and Malele, Imna and Koekemoer, Jacobus JO and Auma, Joanna E and Kinyua, Johnson K and Ouma, Johnson and Watanabe, Junichi and Megy, Karyn and Okedi, Loyce and Manga, Lucien and Jonas, Mario and Wamalwa, Mark and Aslett, Martin and Koffi, Mathurin and Berriman, Matthew and Lehane, Michael J and Gaunt, Michael W and Makgamathe, Mmule and Hall, Neil and Mulder, Nicola and Manangwa, Oliver and Abila, Patrick P and Wincker, Patrick and Mireji, Paul O and Gregory, Richard and Rio, Rita VM and Bateta, Rosemary and Sakate, Ryuichi and Aksoy, Serap and Ommeh, Sheila and Lehane, Stella and Nyanjom, Steven RG and Imanishi, Tadashi and Taylor, Todd D and Osamor, Victor C and Sharma, Vineet and Hide, Winston and Kawahara, Yoshihiro and Benoit, Joshua B}},
  issn         = {{0036-8075}},
  journal      = {{SCIENCE}},
  keywords     = {{PERITROPHIC MATRIX,IMMUNE-RESPONSES,AQUAPORINS,PROTEINS,DIPTERA,FLIES}},
  language     = {{eng}},
  number       = {{6182}},
  pages        = {{380--386}},
  title        = {{Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis}},
  url          = {{http://dx.doi.org/10.1126/science.1249656}},
  volume       = {{344}},
  year         = {{2014}},
}

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