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In vitro antimicrobial activity of plants used in traditional medicine in Gurage and Silti Zones, south central Ethiopia

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Abstract
Background: To overcome the escalating problems associated with infectious diseases and drug resistance, discovery of new antimicrobials is crucial. The present study aimed to carry out in vitro antimicrobial analysis of 15 medicinal plant species selected according to their traditional medicinal uses in Gurage and Silti Zones, south central Ethiopia. Methods: Ethanol extracts of various plant parts were investigated for their antimicrobial activity against 20 bacterial and one yeast strains. The minimum inhibitory concentration (MIC) was determined by broth microdilution method. Results: Asparagus africanus, Guizotia schimperi, Lippia adoensis var. adoensis and Premna schimperi were active against Candida albicans, Enterococcus faecalis and Staphylococcus aureus at a concentration of 512 mu g/ml or lower. Strong antibacterial activity (MIC >= 128 mu g/ml) was observed for G. schimperi extract against 17 resistant and sensitive Staphylococcus strains, at a concentration comparable to standard antibiotics. Moreover, this extract showed higher antibacterial activity for the test against S. aureus ATCC 33591, ATCC 33592, SA3 and SA5 strains (128-256 mu g/ml) than oxacillin (512 mu g/ml). Conclusions: The study revealed in vitro antibacterial activity of plants used in folk medicine in south central Ethiopia. The usefulness of these plants, in particular of G. schimperi, should be confirmed through further phytochemical and toxicity analyses.
Keywords
Anti-staphylococcal, Antibiotic-resistance, Ethnomedicine, Ethnopharmacology, Guizotia schimperi, PRODUCTS, TAXA

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Chicago
Teka Sahile, Alemtshay, Johana Rondevaldova, Zemede Asfaw, Sebsebe Demissew, Patrick Van Damme, Ladislav Kokoska, and Wouter Vanhove. 2015. “In Vitro Antimicrobial Activity of Plants Used in Traditional Medicine in Gurage and Silti Zones, South Central Ethiopia.” Bmc Complementary and Alternative Medicine 15.
APA
Teka Sahile, A., Rondevaldova, J., Asfaw, Z., Demissew, S., Van Damme, P., Kokoska, L., & Vanhove, W. (2015). In vitro antimicrobial activity of plants used in traditional medicine in Gurage and Silti Zones, south central Ethiopia. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 15.
Vancouver
1.
Teka Sahile A, Rondevaldova J, Asfaw Z, Demissew S, Van Damme P, Kokoska L, et al. In vitro antimicrobial activity of plants used in traditional medicine in Gurage and Silti Zones, south central Ethiopia. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2015;15.
MLA
Teka Sahile, Alemtshay, Johana Rondevaldova, Zemede Asfaw, et al. “In Vitro Antimicrobial Activity of Plants Used in Traditional Medicine in Gurage and Silti Zones, South Central Ethiopia.” BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15 (2015): n. pag. Print.
@article{6902425,
  abstract     = {Background: To overcome the escalating problems associated with infectious diseases and drug resistance, discovery of new antimicrobials is crucial. The present study aimed to carry out in vitro antimicrobial analysis of 15 medicinal plant species selected according to their traditional medicinal uses in Gurage and Silti Zones, south central Ethiopia. 
Methods: Ethanol extracts of various plant parts were investigated for their antimicrobial activity against 20 bacterial and one yeast strains. The minimum inhibitory concentration (MIC) was determined by broth microdilution method. 
Results: Asparagus africanus, Guizotia schimperi, Lippia adoensis var. adoensis and Premna schimperi were active against Candida albicans, Enterococcus faecalis and Staphylococcus aureus at a concentration of 512 mu g/ml or lower. Strong antibacterial activity (MIC {\textrangle}= 128 mu g/ml) was observed for G. schimperi extract against 17 resistant and sensitive Staphylococcus strains, at a concentration comparable to standard antibiotics. Moreover, this extract showed higher antibacterial activity for the test against S. aureus ATCC 33591, ATCC 33592, SA3 and SA5 strains (128-256 mu g/ml) than oxacillin (512 mu g/ml). 
Conclusions: The study revealed in vitro antibacterial activity of plants used in folk medicine in south central Ethiopia. The usefulness of these plants, in particular of G. schimperi, should be confirmed through further phytochemical and toxicity analyses.},
  articleno    = {286},
  author       = {Teka Sahile, Alemtshay and Rondevaldova, Johana and  Asfaw, Zemede and  Demissew, Sebsebe and Van Damme, Patrick and Kokoska, Ladislav and Vanhove, Wouter},
  issn         = {1472-6882},
  journal      = {BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE},
  language     = {eng},
  pages        = {7},
  title        = {In vitro antimicrobial activity of plants used in traditional medicine in Gurage and Silti Zones, south central Ethiopia},
  url          = {http://dx.doi.org/10.1186/s12906-015-0822-1},
  volume       = {15},
  year         = {2015},
}

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