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Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

(2015) VIRCHOWS ARCHIV. 467(4). p.367-382
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Abstract
Cancer-associated fibroblasts (CAFs) are drivers of tumour progression and are considered as a target and a tool in cancer diagnostic and therapeutic applications. An increased abundance of CAFs or CAF signatures are recognized as a bad prognostic marker in several cancer types. Tumour-environment biomimetics strongly improve our understanding of the communication between CAFs, cancer cells and other host cells. Several experimental drugs targeting CAFs are in clinical trials for multiple tumour entities; alternatively, CAFs can be exploited as a tool to characterize the functionality of circulating tumour cells or to capture them as a tool to prevent metastasis. The continuous interaction between tissue engineers, biomaterial experts and cancer researchers creates the possibility to biomimic the tumour-environment and provides new opportunities in cancer diagnostics and management.
Keywords
CAF's, diagnostics, therapy, Tumor-environment, biomimetics, SQUAMOUS-CELL CARCINOMA, SMOOTH MUSCLE ACTIN, IDIOPATHIC PULMONARY-FIBROSIS, TUMOR-STROMA RATIO, GENE-EXPRESSION SIGNATURE, INVASIVE DUCTAL CARCINOMA, MESENCHYMAL STEM-CELLS, COLORECTAL-CANCER, BREAST-CANCER, PODOPLANIN EXPRESSION

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Citation

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Chicago
De Vlieghere, Elly, Laurine Verset, Pieter Demetter, Marc Bracke, and Olivier De Wever. 2015. “Cancer-associated Fibroblasts as Target and Tool in Cancer Therapeutics and Diagnostics.” Virchows Archiv 467 (4): 367–382.
APA
De Vlieghere, E., Verset, L., Demetter, P., Bracke, M., & De Wever, O. (2015). Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics. VIRCHOWS ARCHIV, 467(4), 367–382.
Vancouver
1.
De Vlieghere E, Verset L, Demetter P, Bracke M, De Wever O. Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics. VIRCHOWS ARCHIV. 2015;467(4):367–82.
MLA
De Vlieghere, Elly, Laurine Verset, Pieter Demetter, et al. “Cancer-associated Fibroblasts as Target and Tool in Cancer Therapeutics and Diagnostics.” VIRCHOWS ARCHIV 467.4 (2015): 367–382. Print.
@article{6900504,
  abstract     = {Cancer-associated fibroblasts (CAFs) are drivers of tumour progression and are considered as a target and a tool in cancer diagnostic and therapeutic applications. An increased abundance of CAFs or CAF signatures are recognized as a bad prognostic marker in several cancer types. Tumour-environment biomimetics strongly improve our understanding of the communication between CAFs, cancer cells and other host cells. Several experimental drugs targeting CAFs are in clinical trials for multiple tumour entities; alternatively, CAFs can be exploited as a tool to characterize the functionality of circulating tumour cells or to capture them as a tool to prevent metastasis. The continuous interaction between tissue engineers, biomaterial experts and cancer researchers creates the possibility to biomimic the tumour-environment and provides new opportunities in cancer diagnostics and management.},
  author       = {De Vlieghere, Elly and Verset, Laurine and Demetter, Pieter and Bracke, Marc and De Wever, Olivier},
  issn         = {0945-6317},
  journal      = {VIRCHOWS ARCHIV},
  language     = {eng},
  number       = {4},
  pages        = {367--382},
  title        = {Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics},
  url          = {http://dx.doi.org/10.1007/s00428-015-1818-4},
  volume       = {467},
  year         = {2015},
}

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