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A novel Malonamide Periodic Mesoporous Organosilica (PMO) for controlled Ibuprofen release

Sander Clerick (UGent) , Wannes Libbrecht (UGent) , Otto van den Berg (UGent) , Els De Canck (UGent) , Jeriffa De Clercq (UGent) and Pascal Van Der Voort (UGent)
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Abstract
Controlled drug release gained a sharply increasing interest over recent years. Multiple materials have been screened as possible drug carriers, ranging from biodegradable polymers to hydroxyapatite[1]. Periodic Mesoporous Organosilicas are valuable alternatives as they possess a high chemical and thermal stability combined with a biocompatible nature[2]. Furthermore, their large internal surface area permits a high drug loading. Careful selection of the organic ‘bridged’ functionality allows a controlled release with respect to external stimuli, such as pH or temperature, of the drugs which are adsorbed via weak and reversible interactions, e.g. H-bonding, ionic and hydrophobic-phobic interaction[3]. In this contribution a novel malonamide (MA-PMO) and a methyl-malonamide PMO (mMA-PMO) bearing a high amount of functionalities, capable of multiple intramolecular interactions, are developed and thoroughly characterized[4]. Subsequently, these hybrid materials are evaluated in the controlled drug release of Ibuprofen.

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MLA
Clerick, Sander, et al. “A Novel Malonamide Periodic Mesoporous Organosilica (PMO) for Controlled Ibuprofen Release.” Advanced Complex Inorganic Nanomaterials, 3rd International Conference, Abstracts, 2015.
APA
Clerick, S., Libbrecht, W., van den Berg, O., De Canck, E., De Clercq, J., & Van Der Voort, P. (2015). A novel Malonamide Periodic Mesoporous Organosilica (PMO) for controlled Ibuprofen release. In Advanced Complex Inorganic Nanomaterials, 3rd International conference, Abstracts. Namur, Belgium.
Chicago author-date
Clerick, Sander, Wannes Libbrecht, Otto van den Berg, Els De Canck, Jeriffa De Clercq, and Pascal Van Der Voort. 2015. “A Novel Malonamide Periodic Mesoporous Organosilica (PMO) for Controlled Ibuprofen Release.” In Advanced Complex Inorganic Nanomaterials, 3rd International Conference, Abstracts.
Chicago author-date (all authors)
Clerick, Sander, Wannes Libbrecht, Otto van den Berg, Els De Canck, Jeriffa De Clercq, and Pascal Van Der Voort. 2015. “A Novel Malonamide Periodic Mesoporous Organosilica (PMO) for Controlled Ibuprofen Release.” In Advanced Complex Inorganic Nanomaterials, 3rd International Conference, Abstracts.
Vancouver
1.
Clerick S, Libbrecht W, van den Berg O, De Canck E, De Clercq J, Van Der Voort P. A novel Malonamide Periodic Mesoporous Organosilica (PMO) for controlled Ibuprofen release. In: Advanced Complex Inorganic Nanomaterials, 3rd International conference, Abstracts. 2015.
IEEE
[1]
S. Clerick, W. Libbrecht, O. van den Berg, E. De Canck, J. De Clercq, and P. Van Der Voort, “A novel Malonamide Periodic Mesoporous Organosilica (PMO) for controlled Ibuprofen release,” in Advanced Complex Inorganic Nanomaterials, 3rd International conference, Abstracts, Namur, Belgium, 2015.
@inproceedings{6898557,
  abstract     = {Controlled drug release gained a sharply increasing interest over recent years. Multiple materials have been screened as possible drug carriers, ranging from biodegradable polymers to hydroxyapatite[1]. Periodic Mesoporous Organosilicas are valuable alternatives as they possess a high chemical and thermal stability combined with a biocompatible nature[2]. Furthermore, their large internal surface area permits a high drug loading. Careful selection of the organic ‘bridged’ functionality allows a controlled release with respect to external stimuli, such as pH or temperature, of the drugs which are adsorbed via weak and reversible interactions, e.g. H-bonding, ionic and hydrophobic-phobic interaction[3]. In this contribution a novel malonamide (MA-PMO) and a methyl-malonamide PMO (mMA-PMO) bearing a high amount of functionalities, capable of multiple intramolecular interactions, are developed and thoroughly characterized[4]. Subsequently, these hybrid materials are evaluated in the controlled drug release of Ibuprofen.},
  author       = {Clerick, Sander and Libbrecht, Wannes and van den Berg, Otto and De Canck, Els and De Clercq, Jeriffa and Van Der Voort, Pascal},
  booktitle    = {Advanced Complex Inorganic Nanomaterials, 3rd International conference, Abstracts},
  language     = {eng},
  location     = {Namur, Belgium},
  title        = {A novel Malonamide Periodic Mesoporous Organosilica (PMO) for controlled Ibuprofen release},
  year         = {2015},
}