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When fat becomes an ally of the enemy : adipose tissue as collaborator in human breast cancer

Lore Lapeire (UGent), Hannelore Denys (UGent), Veronique Cocquyt (UGent) and Olivier De Wever (UGent)
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Abstract
Since the discovery of leptin in 1994, our vision of adipose tissue as a static organ regulating mainly lipid storage and release has been completely overthrown, and adipose tissue is now seen as an active and integral organ in human physiology. In the past years, extensive research has tremendously given us more insights in the mechanisms and pathways involved not only in normal but also in 'sick' adipose tissue, for example, in obesity and lipodystrophy. With growing evidence of a link between obesity and several types of cancer, research focusing on the interaction between adipose tissue and cancer has begun to unravel the interesting but complex multi-lateral communication between the different players. With breast cancer as one of the first cancer types where a positive correlation between obesity and breast cancer incidence and prognosis in post-menopausal women was found, we have focused this review on the paracrine and endocrine role of adipose tissue in breast cancer initiation and progression. As important inter-species differences in adipose tissue occur, we mainly selected human adipose tissue- and breast cancer-based studies with a short reflection on therapeutic possibilities.
Keywords
adipokines, adipose tissue, breast cancer, browning of adipose tissue, hormone metabolism, invasion, lipid metabolism, obesity, progression, BODY-MASS INDEX, CARCINOMA-ASSOCIATED FIBROBLASTS, TUMOR-INFILTRATING LYMPHOCYTES, MECHANISMS LINKING OBESITY, SERUM ADIPONECTIN LEVELS, GENE-EXPRESSION, BROWN FAT, INSULIN-RESISTANCE, PHYSICAL-ACTIVITY, CAVEOLIN-1 EXPRESSION

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Chicago
Lapeire, Lore, Hannelore Denys, Veronique Cocquyt, and Olivier De Wever. 2015. “When Fat Becomes an Ally of the Enemy : Adipose Tissue as Collaborator in Human Breast Cancer.” Hormone Molecular Biology and Clinical Investigation 23 (1): 21–38.
APA
Lapeire, Lore, Denys, H., Cocquyt, V., & De Wever, O. (2015). When fat becomes an ally of the enemy : adipose tissue as collaborator in human breast cancer. HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 23(1), 21–38.
Vancouver
1.
Lapeire L, Denys H, Cocquyt V, De Wever O. When fat becomes an ally of the enemy : adipose tissue as collaborator in human breast cancer. HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2015;23(1):21–38.
MLA
Lapeire, Lore, Hannelore Denys, Veronique Cocquyt, et al. “When Fat Becomes an Ally of the Enemy : Adipose Tissue as Collaborator in Human Breast Cancer.” HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION 23.1 (2015): 21–38. Print.
@article{6897946,
  abstract     = {Since the discovery of leptin in 1994, our vision of adipose tissue as a static organ regulating mainly lipid storage and release has been completely overthrown, and adipose tissue is now seen as an active and integral organ in human physiology. In the past years, extensive research has tremendously given us more insights in the mechanisms and pathways involved not only in normal but also in 'sick' adipose tissue, for example, in obesity and lipodystrophy. With growing evidence of a link between obesity and several types of cancer, research focusing on the interaction between adipose tissue and cancer has begun to unravel the interesting but complex multi-lateral communication between the different players. With breast cancer as one of the first cancer types where a positive correlation between obesity and breast cancer incidence and prognosis in post-menopausal women was found, we have focused this review on the paracrine and endocrine role of adipose tissue in breast cancer initiation and progression. As important inter-species differences in adipose tissue occur, we mainly selected human adipose tissue- and breast cancer-based studies with a short reflection on therapeutic possibilities.},
  author       = {Lapeire, Lore and Denys, Hannelore and Cocquyt, Veronique and De Wever, Olivier},
  issn         = {1868-1883},
  journal      = {HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION},
  keyword      = {adipokines,adipose tissue,breast cancer,browning of adipose tissue,hormone metabolism,invasion,lipid metabolism,obesity,progression,BODY-MASS INDEX,CARCINOMA-ASSOCIATED FIBROBLASTS,TUMOR-INFILTRATING LYMPHOCYTES,MECHANISMS LINKING OBESITY,SERUM ADIPONECTIN LEVELS,GENE-EXPRESSION,BROWN FAT,INSULIN-RESISTANCE,PHYSICAL-ACTIVITY,CAVEOLIN-1 EXPRESSION},
  language     = {eng},
  number       = {1},
  pages        = {21--38},
  title        = {When fat becomes an ally of the enemy : adipose tissue as collaborator in human breast cancer},
  url          = {http://dx.doi.org/10.1515/hmbci-2015-0018},
  volume       = {23},
  year         = {2015},
}

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