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Abstract
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
Keywords
microvesicle, extracellular vesicle, microparticle, exosome, physiology, prokaryote, eukaryote, OUTER-MEMBRANE VESICLES, CELL-DERIVED EXOSOMES, MESENCHYMAL STEM-CELLS, INTESTINAL EPITHELIAL-CELLS, MATURE DENDRITIC CELLS, SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES, IMMUNE-MODULATORY FEATURES, PLANT-MICROBE INTERACTIONS, FACTOR PATHWAY INHIBITOR, HUMAN ENDOTHELIAL-CELLS

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MLA
Yáñez-Mó, María, Pia R-M Siljander, Zoraida Andreu, et al. “Biological Properties of Extracellular Vesicles and Their Physiological Functions.” JOURNAL OF EXTRACELLULAR VESICLES 4 (2015): n. pag. Print.
APA
Yáñez-Mó, M., Siljander, P. R.-M., Andreu, Z., Zavec, A. B., Borràs, F. E., Buzas, E. I., Buzas, K., et al. (2015). Biological properties of extracellular vesicles and their physiological functions. JOURNAL OF EXTRACELLULAR VESICLES, 4.
Chicago author-date
Yáñez-Mó, María, Pia R-M Siljander, Zoraida Andreu, Apolonija Bedina Zavec, Francesc E Borràs, Edit I Buzas, Krisztina Buzas, et al. 2015. “Biological Properties of Extracellular Vesicles and Their Physiological Functions.” Journal of Extracellular Vesicles 4.
Chicago author-date (all authors)
Yáñez-Mó, María, Pia R-M Siljander, Zoraida Andreu, Apolonija Bedina Zavec, Francesc E Borràs, Edit I Buzas, Krisztina Buzas, Enriqueta Casal, Francesco Cappello, Joana Carvalho, Eva Colás, Anabela Cordeiro-da Silva, Stefano Fais, Juan M Falcon-Perez, Irene M Ghobrial, Bernd Giebel, Mario Gimona, Michael Graner, Ihsan Gursel, Mayda Gursel, Niels HH Heegaard, An Hendrix, Peter Kierulf, Katsutoshi Kokubun, Maja Kosanovic, Veronika Krali-Iglic, Eva-Maria Krämer-Albers, Saara Laitinen, Cecilia Lässer, Thomas Lener, Erzsébet Ligeti, Aija Linē, Georg Lipps, Alicia Llorente, Jan Lötvall, Mateja Manček-Keber, Antonio Marcilla, Maria Mittelbrunn, Irina Nazarenko, Esther Nolte-’t Hoen, Tuula A Nyman, Lorraine O’Driscoll, Mireia Olivan, Carla Oliveira, Éva Pállinger, Hernando A del Portillo, Jaume Reventós, Marina Rigau, Eva Rohde, Marei Sammar, Francisco Sánchez-Madrid, N Santarém, Katharina Schallmoser, Marie Stampe Ostenfeld, Willem Stoorvogel, Roman Stukelj, Susanne G Van der Grein, M Helena Vasconcelos, Marca HM Wauben, and Olivier De Wever. 2015. “Biological Properties of Extracellular Vesicles and Their Physiological Functions.” Journal of Extracellular Vesicles 4.
Vancouver
1.
Yáñez-Mó M, Siljander PR-M, Andreu Z, Zavec AB, Borràs FE, Buzas EI, et al. Biological properties of extracellular vesicles and their physiological functions. JOURNAL OF EXTRACELLULAR VESICLES. 2015;4.
IEEE
[1]
M. Yáñez-Mó et al., “Biological properties of extracellular vesicles and their physiological functions,” JOURNAL OF EXTRACELLULAR VESICLES, vol. 4, 2015.
@article{6897651,
  abstract     = {In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.},
  articleno    = {27066},
  author       = {Yáñez-Mó, María and Siljander, Pia R-M and Andreu, Zoraida and Zavec, Apolonija Bedina and Borràs, Francesc E and Buzas, Edit I and Buzas, Krisztina and Casal, Enriqueta and Cappello, Francesco and Carvalho, Joana and Colás, Eva and  Cordeiro-da Silva, Anabela and Fais, Stefano and Falcon-Perez, Juan M and Ghobrial, Irene M and Giebel, Bernd and Gimona, Mario and Graner, Michael and Gursel, Ihsan and Gursel, Mayda and Heegaard, Niels HH and Hendrix, An and Kierulf, Peter and Kokubun, Katsutoshi and Kosanovic, Maja and Krali-Iglic, Veronika and Krämer-Albers, Eva-Maria and Laitinen, Saara and Lässer, Cecilia and Lener, Thomas and Ligeti, Erzsébet and Linē, Aija and Lipps, Georg and Llorente, Alicia and Lötvall, Jan and Manček-Keber, Mateja and Marcilla, Antonio and Mittelbrunn, Maria and Nazarenko, Irina and Nolte-'t Hoen, Esther and Nyman, Tuula A and O'Driscoll, Lorraine and Olivan, Mireia and Oliveira, Carla and Pállinger, Éva and del Portillo, Hernando A and Reventós, Jaume and Rigau, Marina and Rohde, Eva and Sammar, Marei and Sánchez-Madrid, Francisco and Santarém, N and Schallmoser, Katharina and Stampe Ostenfeld, Marie and Stoorvogel, Willem and Stukelj, Roman and Van der Grein, Susanne G and Vasconcelos, M Helena and Wauben, Marca HM and De Wever, Olivier},
  issn         = {2001-3078},
  journal      = {JOURNAL OF EXTRACELLULAR VESICLES},
  keywords     = {microvesicle,extracellular vesicle,microparticle,exosome,physiology,prokaryote,eukaryote,OUTER-MEMBRANE VESICLES,CELL-DERIVED EXOSOMES,MESENCHYMAL STEM-CELLS,INTESTINAL EPITHELIAL-CELLS,MATURE DENDRITIC CELLS,SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES,IMMUNE-MODULATORY FEATURES,PLANT-MICROBE INTERACTIONS,FACTOR PATHWAY INHIBITOR,HUMAN ENDOTHELIAL-CELLS},
  language     = {eng},
  pages        = {60},
  title        = {Biological properties of extracellular vesicles and their physiological functions},
  url          = {http://dx.doi.org/10.3402/jev.v4.27066},
  volume       = {4},
  year         = {2015},
}

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