@article{6897651,
  abstract     = {{In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.}},
  articleno    = {{27066}},
  author       = {{Yáñez-Mó, María and Siljander, Pia R-M and Andreu, Zoraida and Zavec, Apolonija Bedina and Borràs, Francesc E and Buzas, Edit I and Buzas, Krisztina and Casal, Enriqueta and Cappello, Francesco and Carvalho, Joana and Colás, Eva and Cordeiro-da Silva, Anabela and Fais, Stefano and Falcon-Perez, Juan M and Ghobrial, Irene M and Giebel, Bernd and Gimona, Mario and Graner, Michael and Gursel, Ihsan and Gursel, Mayda and Heegaard, Niels HH and Hendrix, An and Kierulf, Peter and Kokubun, Katsutoshi and Kosanovic, Maja and Krali-Iglic, Veronika and Krämer-Albers, Eva-Maria and Laitinen, Saara and Lässer, Cecilia and Lener, Thomas and Ligeti, Erzsébet and Linē, Aija and Lipps, Georg and Llorente, Alicia and Lötvall, Jan and Manček-Keber, Mateja and Marcilla, Antonio and Mittelbrunn, Maria and Nazarenko, Irina and Nolte-'t Hoen, Esther and Nyman, Tuula A and O'Driscoll, Lorraine and Olivan, Mireia and Oliveira, Carla and Pállinger, Éva and del Portillo, Hernando A and Reventós, Jaume and Rigau, Marina and Rohde, Eva and Sammar, Marei and Sánchez-Madrid, Francisco and Santarém, N and Schallmoser, Katharina and Stampe Ostenfeld, Marie and Stoorvogel, Willem and Stukelj, Roman and Van der Grein, Susanne G and Vasconcelos, M Helena and Wauben, Marca HM and De Wever, Olivier}},
  issn         = {{2001-3078}},
  journal      = {{JOURNAL OF EXTRACELLULAR VESICLES}},
  keywords     = {{microvesicle,extracellular vesicle,microparticle,exosome,physiology,prokaryote,eukaryote,OUTER-MEMBRANE VESICLES,CELL-DERIVED EXOSOMES,MESENCHYMAL STEM-CELLS,INTESTINAL EPITHELIAL-CELLS,MATURE DENDRITIC CELLS,SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES,IMMUNE-MODULATORY FEATURES,PLANT-MICROBE INTERACTIONS,FACTOR PATHWAY INHIBITOR,HUMAN ENDOTHELIAL-CELLS}},
  language     = {{eng}},
  pages        = {{60}},
  title        = {{Biological properties of extracellular vesicles and their physiological functions}},
  url          = {{http://doi.org/10.3402/jev.v4.27066}},
  volume       = {{4}},
  year         = {{2015}},
}

Altmetric

View in Altmetric