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A case of chronic recurrent multifocal osteomyelitis associated with Crohn's disease

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Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory bone disease of unknown etiology, most commonly affecting the metaphysis of long bones, especially the tibia, femur and clavicle. The clinical spectrum varies from self-limited uni-or multi-focal lesions to chronic recurrent courses. Diagnosis is based on clinical, radiologic and pathological findings, is probably under-diagnosed due to poor recognition of the disease. A dysregulated innate immunity causes immune cell infiltration of the bones with subsequent osteoclast activation leading to sterile bone lesions. The molecular pathophyiology is still incompletely understood but association with other auto-inflammatory diseases such as inflammatory bowel disease (IBD), psoriasis, Wegener's disease, arthritis and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is interesting. CRMO can precede the symptoms of the associated disease by several years. The bone remodeling caused by CRMO can cause permanent disability. We report the case of a 10-year-old boy with CRMO in association with Crohn's disease.
Keywords
inflammatory bowel disease, chronic recurrent multifocal osteomyelitis, Crohn's disease, non-bacterial osteomyelitis, INFLAMMATORY-BOWEL-DISEASE, ULCERATIVE-COLITIS, CHILDREN, CRMO, INVOLVEMENT, THERAPY

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Chicago
van Ommen, Christi, Jo Dehoorne, Frans De Baets, Saskia Vande Velde, Myriam Van Winckel, and Stephanie Van Biervliet. 2015. “A Case of Chronic Recurrent Multifocal Osteomyelitis Associated with Crohn’s Disease.” Acta Gastro-enterologica Belgica 78 (2): 240–243.
APA
van Ommen, C., Dehoorne, J., De Baets, F., Vande Velde, S., Van Winckel, M., & Van Biervliet, S. (2015). A case of chronic recurrent multifocal osteomyelitis associated with Crohn’s disease. ACTA GASTRO-ENTEROLOGICA BELGICA, 78(2), 240–243.
Vancouver
1.
van Ommen C, Dehoorne J, De Baets F, Vande Velde S, Van Winckel M, Van Biervliet S. A case of chronic recurrent multifocal osteomyelitis associated with Crohn’s disease. ACTA GASTRO-ENTEROLOGICA BELGICA. 2015;78(2):240–3.
MLA
van Ommen, Christi, Jo Dehoorne, Frans De Baets, et al. “A Case of Chronic Recurrent Multifocal Osteomyelitis Associated with Crohn’s Disease.” ACTA GASTRO-ENTEROLOGICA BELGICA 78.2 (2015): 240–243. Print.
@article{6896728,
  abstract     = {Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory bone disease of unknown etiology, most commonly affecting the metaphysis of long bones, especially the tibia, femur and clavicle. The clinical spectrum varies from self-limited uni-or multi-focal lesions to chronic recurrent courses. Diagnosis is based on clinical, radiologic and pathological findings, is probably under-diagnosed due to poor recognition of the disease. A dysregulated innate immunity causes immune cell infiltration of the bones with subsequent osteoclast activation leading to sterile bone lesions. The molecular pathophyiology is still incompletely understood but association with other auto-inflammatory diseases such as inflammatory bowel disease (IBD), psoriasis, Wegener's disease, arthritis and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is interesting. CRMO can precede the symptoms of the associated disease by several years. The bone remodeling caused by CRMO can cause permanent disability. We report the case of a 10-year-old boy with CRMO in association with Crohn's disease.},
  author       = {van Ommen, Christi and Dehoorne, Jo and De Baets, Frans and Vande Velde, Saskia and Van Winckel, Myriam and Van Biervliet, Stephanie},
  issn         = {0001-5644},
  journal      = {ACTA GASTRO-ENTEROLOGICA BELGICA},
  language     = {eng},
  number       = {2},
  pages        = {240--243},
  title        = {A case of chronic recurrent multifocal osteomyelitis associated with Crohn's disease},
  volume       = {78},
  year         = {2015},
}

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