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Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species

(2015) PLOS ONE. 10(7).
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Abstract
The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was to investigate the pharmacokinetics of carboplatin in a representative species of the order of Galliformes, Anseriformes, Columbiformes and Psittaciformes. Eight chickens, ducks and pigeons and twenty-eight parakeets were administered carboplatin intravenously (5 mg/kg body weight). A specific and sensitive liquid chromatographytandem mass spectrometry method was developed and validated for quantification of the free carboplatin in plasma of the four birds species (limit of quantification: 20 ng/mL for chicken and duck, 50 ng/mL for pigeon and 100 ng/mL for parakeets). Non-compartmental pharmacokinetic analysis and allometric scaling demonstrated a significant correlation (R²=0.9769) between body weight (BW) and elimination half-life (T1/2el). T1/2el ranged from 0.41h in parakeets (BW: 61 ± 8 g) to 1.16 h chickens (BW: 1909 ± 619 g). T1/2el is a good parameter for dose optimization of carboplatin in other avian species, since also the previously reported T1/2el in cockatoos (average BW: 769 ± 68 g) of 1.00 h corresponds to the results obtained in the present study.
Keywords
allometric scaling, pharmacokinetic, avian species, carboplatin, TANDEM MASS-SPECTROMETRY, HUMAN PLASMA, GLOMERULAR-FILTRATION, RENAL-FUNCTION, DRUGS, TUMOR, CLEARANCE, TOXICITY

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MLA
Antonissen, Gunther et al. “Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species.” PLOS ONE 10.7 (2015): n. pag. Print.
APA
Antonissen, G., Devreese, M., De Baere, S., Hellebuyck, T., Van de Maele, I., Rouffaer, L., Stemkens, H. J., et al. (2015). Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species. PLOS ONE, 10(7).
Chicago author-date
Antonissen, Gunther, Mathias Devreese, Siegrid De Baere, Tom Hellebuyck, Isabel Van de Maele, Lieze Rouffaer, Hendrickus JJ Stemkens, Patrick De Backer, An Martel, and Siska Croubels. 2015. “Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species.” Plos One 10 (7).
Chicago author-date (all authors)
Antonissen, Gunther, Mathias Devreese, Siegrid De Baere, Tom Hellebuyck, Isabel Van de Maele, Lieze Rouffaer, Hendrickus JJ Stemkens, Patrick De Backer, An Martel, and Siska Croubels. 2015. “Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species.” Plos One 10 (7).
Vancouver
1.
Antonissen G, Devreese M, De Baere S, Hellebuyck T, Van de Maele I, Rouffaer L, et al. Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species. PLOS ONE. 2015;10(7).
IEEE
[1]
G. Antonissen et al., “Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species,” PLOS ONE, vol. 10, no. 7, 2015.
@article{6890831,
  abstract     = {The use of chemotherapeutics as a possible treatment strategy in avian oncology is steadily increasing over the last years. Despite this, literature reports regarding dosing strategies and pharmacokinetic behaviour of chemotherapeutics in avian species are lacking. The aim of the present study was to investigate the pharmacokinetics of carboplatin in a representative species of the order of Galliformes, Anseriformes, Columbiformes and Psittaciformes. Eight chickens, ducks and pigeons and twenty-eight parakeets were administered carboplatin intravenously (5 mg/kg body weight). A specific and sensitive liquid chromatographytandem mass spectrometry method was developed and validated for quantification of the free carboplatin in plasma of the four birds species (limit of quantification: 20 ng/mL for chicken and duck, 50 ng/mL for pigeon and 100 ng/mL for parakeets). Non-compartmental pharmacokinetic analysis and allometric scaling demonstrated a significant correlation (R²=0.9769) between body weight (BW) and elimination half-life (T1/2el). T1/2el ranged from 0.41h in parakeets (BW: 61 ± 8 g) to 1.16 h chickens (BW: 1909 ± 619 g). T1/2el is a good parameter for dose optimization of carboplatin in other avian species, since also the previously reported T1/2el in cockatoos (average BW: 769 ± 68 g) of 1.00 h corresponds to the results obtained in the present study.},
  articleno    = {e0134177},
  author       = {Antonissen, Gunther and Devreese, Mathias and De Baere, Siegrid and Hellebuyck, Tom and Van de Maele, Isabel and Rouffaer, Lieze and Stemkens, Hendrickus JJ and De Backer, Patrick and Martel, An and Croubels, Siska},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {allometric scaling,pharmacokinetic,avian species,carboplatin,TANDEM MASS-SPECTROMETRY,HUMAN PLASMA,GLOMERULAR-FILTRATION,RENAL-FUNCTION,DRUGS,TUMOR,CLEARANCE,TOXICITY},
  language     = {eng},
  number       = {7},
  pages        = {11},
  title        = {Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species},
  url          = {http://dx.doi.org/10.1371/journal.pone.0134177},
  volume       = {10},
  year         = {2015},
}

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