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Classification of peptides according to their blood-brain barrier influx

Sofie Stalmans (UGent) , Bert Gevaert (UGent) , Evelien Wynendaele (UGent) , Joachim Nielandt (UGent) , Guy De Tré (UGent) , Kathelijne Peremans (UGent) , Christian Burvenich (UGent) and Bart De Spiegeleer (UGent)
(2015) PROTEIN AND PEPTIDE LETTERS. 22(9). p.768-775
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Abstract
An increasing number of studies demonstrate the ability of peptides to cross the blood-brain barrier (BBB), opening perspectives for a new class of therapeutics for central nervous system diseases. However, information on the BBB transport of peptides suffer from a wide variety in used methods and experimental set-up. Therefore, it is currently difficult, if not impossible, to classify peptides according to their BBB influx characteristics. To allow direct comparison of BBB influx results of peptides, we introduce a classification method and unified response for BBB influx transport of peptides. First, the results of BBB influx response types (i.e. Kin (MTR), Kin (Perfusion), Pin vitro and Pin vivo), which quantitatively express brain influx, were classified into five classes of BBB influx magnitude based on the distribution of these results for the individual response types. Then, these classes were converted to a BBBin-response, representing a scaled value ranging from zero (no influx) to ten (high influx), independent from the BBB influx response type from which it was derived. This unified response can immediately be applied for new BBB influx results of peptides and represents a ballpark figure for BBB influx and allows direct comparison and ranking of peptides independent of the response type.
Keywords
peptides, unified response, permeability, influx, classification, Blood-brain barrier, PASSAGE, PERMEABILITY, DRUGS, SATURABLE TRANSPORT

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Chicago
Stalmans, Sofie, Bert Gevaert, Evelien Wynendaele, Joachim Nielandt, Guy De Tré, Kathelijne Peremans, Christian Burvenich, and Bart De Spiegeleer. 2015. “Classification of Peptides According to Their Blood-brain Barrier Influx.” Protein and Peptide Letters 22 (9): 768–775.
APA
Stalmans, S., Gevaert, B., Wynendaele, E., Nielandt, J., De Tré, G., Peremans, K., Burvenich, C., et al. (2015). Classification of peptides according to their blood-brain barrier influx. PROTEIN AND PEPTIDE LETTERS, 22(9), 768–775.
Vancouver
1.
Stalmans S, Gevaert B, Wynendaele E, Nielandt J, De Tré G, Peremans K, et al. Classification of peptides according to their blood-brain barrier influx. PROTEIN AND PEPTIDE LETTERS. 2015;22(9):768–75.
MLA
Stalmans, Sofie et al. “Classification of Peptides According to Their Blood-brain Barrier Influx.” PROTEIN AND PEPTIDE LETTERS 22.9 (2015): 768–775. Print.
@article{6890608,
  abstract     = {An increasing number of studies demonstrate the ability of peptides to cross the blood-brain barrier (BBB), opening perspectives for a new class of therapeutics for central nervous system diseases. However, information on the BBB transport of peptides suffer from a wide variety in used methods and experimental set-up. Therefore, it is currently difficult, if not impossible, to classify peptides according to their BBB influx characteristics. To allow direct comparison of BBB influx results of peptides, we introduce a classification method and unified response for BBB influx transport of peptides. First, the results of BBB influx response types (i.e. Kin (MTR), Kin (Perfusion), Pin vitro and Pin vivo), which quantitatively express brain influx, were classified into five classes of BBB influx magnitude based on the distribution of these results for the individual response types. Then, these classes were converted to a BBBin-response, representing a scaled value ranging from zero (no influx) to ten (high influx), independent from the BBB influx response type from which it was derived. This unified response can immediately be applied for new BBB influx results of peptides and represents a ballpark figure for BBB influx and allows direct comparison and ranking of peptides independent of the response type.},
  author       = {Stalmans, Sofie and Gevaert, Bert and Wynendaele, Evelien and Nielandt, Joachim and De Tré, Guy and Peremans, Kathelijne and Burvenich, Christian and De Spiegeleer, Bart},
  issn         = {0929-8665},
  journal      = {PROTEIN AND PEPTIDE LETTERS},
  keywords     = {peptides,unified response,permeability,influx,classification,Blood-brain barrier,PASSAGE,PERMEABILITY,DRUGS,SATURABLE TRANSPORT},
  language     = {eng},
  number       = {9},
  pages        = {768--775},
  title        = {Classification of peptides according to their blood-brain barrier influx},
  url          = {http://dx.doi.org/10.2174/0929866522666150622101223},
  volume       = {22},
  year         = {2015},
}

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