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IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear

Koen Venken (UGent) and Dirk Elewaut (UGent)
(2015) CURRENT RHEUMATOLOGY REPORTS. 17(5).
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Organization
Abstract
A key role for the IL-23/IL-17 immune axis in spondyloarthritis (SpA) is supported by cumulative evidence from genetic and translational studies and was recently confirmed in clinical trials. Although initially linked to T helper 17 cells, it is now clear that additional unconventional T cell subpopulations respond towards IL-23, including ROR gamma t(+) CD3(+)CD4(-)CD8(-) T cells, TCR gamma delta 17 cells, KIR3DL2(+)CD4(+) T cells and iNKT17 cells. Although these innate-like T cells are present only at low frequencies and often with a specific tissue distribution, it is proposed that they could play a vital function in the development or progression of SpA-related pathology. In this review, we highlight the emerging knowledge on these specialized IL-23 responsive T cells with regard to their relevance in SpA. Finally, we will discuss these findings in light of novel drugs targeting the IL-23/IL-17 axis, currently being tested in SpA patients.
Keywords
IL-23, ROR gamma t, Spondyloarthritis, TCR gamma delta T cells, IL-17, Innate-like T cells, KIR3DL2(+)CD4(+) T cells, iNKT cells, PLACEBO-CONTROLLED TRIAL, UNFOLDED PROTEIN RESPONSE, INVARIANT NKT CELLS, SIGNIFICANTLY IMPROVES SIGNS, ACTIVE PSORIATIC-ARTHRITIS, COLLAGEN-INDUCED ARTHRITIS, PROOF-OF-CONCEPT, ROR-GAMMA-T, ANKYLOSING-SPONDYLITIS, MONOCLONAL-ANTIBODY

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MLA
Venken, Koen, and Dirk Elewaut. “IL-23 Responsive Innate-like T Cells in Spondyloarthritis: The Less Frequent They Are, the More Vital They Appear.” CURRENT RHEUMATOLOGY REPORTS, vol. 17, no. 5, 2015, doi:10.1007/s11926-015-0507-2.
APA
Venken, K., & Elewaut, D. (2015). IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear. CURRENT RHEUMATOLOGY REPORTS, 17(5). https://doi.org/10.1007/s11926-015-0507-2
Chicago author-date
Venken, Koen, and Dirk Elewaut. 2015. “IL-23 Responsive Innate-like T Cells in Spondyloarthritis: The Less Frequent They Are, the More Vital They Appear.” CURRENT RHEUMATOLOGY REPORTS 17 (5). https://doi.org/10.1007/s11926-015-0507-2.
Chicago author-date (all authors)
Venken, Koen, and Dirk Elewaut. 2015. “IL-23 Responsive Innate-like T Cells in Spondyloarthritis: The Less Frequent They Are, the More Vital They Appear.” CURRENT RHEUMATOLOGY REPORTS 17 (5). doi:10.1007/s11926-015-0507-2.
Vancouver
1.
Venken K, Elewaut D. IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear. CURRENT RHEUMATOLOGY REPORTS. 2015;17(5).
IEEE
[1]
K. Venken and D. Elewaut, “IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear,” CURRENT RHEUMATOLOGY REPORTS, vol. 17, no. 5, 2015.
@article{6888058,
  abstract     = {{A key role for the IL-23/IL-17 immune axis in spondyloarthritis (SpA) is supported by cumulative evidence from genetic and translational studies and was recently confirmed in clinical trials. Although initially linked to T helper 17 cells, it is now clear that additional unconventional T cell subpopulations respond towards IL-23, including ROR gamma t(+) CD3(+)CD4(-)CD8(-) T cells, TCR gamma delta 17 cells, KIR3DL2(+)CD4(+) T cells and iNKT17 cells. Although these innate-like T cells are present only at low frequencies and often with a specific tissue distribution, it is proposed that they could play a vital function in the development or progression of SpA-related pathology. In this review, we highlight the emerging knowledge on these specialized IL-23 responsive T cells with regard to their relevance in SpA. Finally, we will discuss these findings in light of novel drugs targeting the IL-23/IL-17 axis, currently being tested in SpA patients.}},
  articleno    = {{30}},
  author       = {{Venken, Koen and Elewaut, Dirk}},
  issn         = {{1523-3774}},
  journal      = {{CURRENT RHEUMATOLOGY REPORTS}},
  keywords     = {{IL-23,ROR gamma t,Spondyloarthritis,TCR gamma delta T cells,IL-17,Innate-like T cells,KIR3DL2(+)CD4(+) T cells,iNKT cells,PLACEBO-CONTROLLED TRIAL,UNFOLDED PROTEIN RESPONSE,INVARIANT NKT CELLS,SIGNIFICANTLY IMPROVES SIGNS,ACTIVE PSORIATIC-ARTHRITIS,COLLAGEN-INDUCED ARTHRITIS,PROOF-OF-CONCEPT,ROR-GAMMA-T,ANKYLOSING-SPONDYLITIS,MONOCLONAL-ANTIBODY}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{8}},
  title        = {{IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear}},
  url          = {{http://doi.org/10.1007/s11926-015-0507-2}},
  volume       = {{17}},
  year         = {{2015}},
}
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