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Pulsed in vitro release and in vivo behavior of exploding microcapsules

Bruno De Geest UGent, Stefaan De Koker UGent, Jo Demeester UGent, Stefaan De Smedt UGent and WE Hennink (2009) Journal of Controlled Release. 135(3). p.268-273
abstract
Drug delivery systems which can generate multiple drug pulses after a single injection can be of major importance for e.g. the delivery of vaccines which often require multiple booster injections to generate sufficient immunity. In this paper, we report self-exploding microcapsules which can release their content in a pulsed fashion after a certain incubation time at physiological conditions. The system is based on a biodegradable microgel core surrounded by a bio-polyelectrolyte membrane. When the microgel core degrades, the swelling pressure increases and finally ruptures the membrane leading to release of the encapsulated materials. We show that the explosion time and subsequent release of 50 nm, latex nanoparticles (used as a model), can be tailored by varying the cross-link density of the microgels. Further we also address the biocompatibility in vivo after subcutaneous injection of the microcapsules; in mice.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SYSTEMS, CELLS, EXOGENOUS ANTIGEN, DEXTRAN MICROSPHERES, POLYELECTROLYTE MICROCAPSULES, DRUG-DELIVERY, MULTILAYER FILM MORPHOLOGY, Microgels, Polyelectrolytes, Pulsed release, Capsules, Drug delivery, PHAGOCYTOSIS, DEGRADATION, MICROCHIP
journal title
Journal of Controlled Release
J. Control. Release
volume
135
issue
3
pages
268 - 273
publisher
Elsevier
Web of Science type
Article
Web of Science id
000265702200012
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
5.949 (2009)
JCR rank
14/236 (2009)
JCR quartile
1 (2009)
ISSN
0168-3659
DOI
10.1016/j.jconrel.2009.01.017
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
688784
handle
http://hdl.handle.net/1854/LU-688784
date created
2009-06-10 15:38:03
date last changed
2009-06-17 14:46:30
@article{688784,
  abstract     = {Drug delivery systems which can generate multiple drug pulses after a single injection can be of major importance for e.g. the delivery of vaccines which often require multiple booster injections to generate sufficient immunity. In this paper, we report self-exploding microcapsules which can release their content in a pulsed fashion after a certain incubation time at physiological conditions. The system is based on a biodegradable microgel core surrounded by a bio-polyelectrolyte membrane. When the microgel core degrades, the swelling pressure increases and finally ruptures the membrane leading to release of the encapsulated materials. We show that the explosion time and subsequent release of 50 nm, latex nanoparticles (used as a model), can be tailored by varying the cross-link density of the microgels. Further we also address the biocompatibility in vivo after subcutaneous injection of the microcapsules; in mice.},
  author       = {De Geest, Bruno and De Koker, Stefaan and Demeester, Jo and De Smedt, Stefaan and Hennink, WE},
  issn         = {0168-3659},
  journal      = {Journal of Controlled Release},
  keyword      = {SYSTEMS,CELLS,EXOGENOUS ANTIGEN,DEXTRAN MICROSPHERES,POLYELECTROLYTE MICROCAPSULES,DRUG-DELIVERY,MULTILAYER FILM MORPHOLOGY,Microgels,Polyelectrolytes,Pulsed release,Capsules,Drug delivery,PHAGOCYTOSIS,DEGRADATION,MICROCHIP},
  language     = {eng},
  number       = {3},
  pages        = {268--273},
  publisher    = {Elsevier},
  title        = {Pulsed in vitro release and in vivo behavior of exploding microcapsules},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2009.01.017},
  volume       = {135},
  year         = {2009},
}

Chicago
De Geest, Bruno, Stefaan De Koker, Jo Demeester, Stefaan De Smedt, and WE Hennink. 2009. “Pulsed in Vitro Release and in Vivo Behavior of Exploding Microcapsules.” Journal of Controlled Release 135 (3): 268–273.
APA
De Geest, B., De Koker, S., Demeester, J., De Smedt, S., & Hennink, W. (2009). Pulsed in vitro release and in vivo behavior of exploding microcapsules. Journal of Controlled Release, 135(3), 268–273.
Vancouver
1.
De Geest B, De Koker S, Demeester J, De Smedt S, Hennink W. Pulsed in vitro release and in vivo behavior of exploding microcapsules. Journal of Controlled Release. Elsevier; 2009;135(3):268–73.
MLA
De Geest, Bruno, Stefaan De Koker, Jo Demeester, et al. “Pulsed in Vitro Release and in Vivo Behavior of Exploding Microcapsules.” Journal of Controlled Release 135.3 (2009): 268–273. Print.