The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination
- Author
- Lynn Elton (UGent) , Isabelle Carpentier (UGent) , Kelly Verhelst (UGent) , Jens Staal (UGent) and Rudi Beyaert (UGent)
- Organization
- Project
- Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
- Abstract
- Ubiquitination controls and fine-tunes many signaling processes driving immunity, inflammation, and cancer. The E3 ubiquitin ligase HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) is increasingly implicated in different signaling pathways and plays a vital role in immune regulation. HOIL-1 co operates with the E3 ubiquitin ligase HOIP (HOIL-1 interacting protein) to modify specific nuclear factor-B (NF-B) signaling proteins with linear M1-linked polyubiquitin chains. In addition, through its ability to also add K48-linked polyubiquitin chains to specific substrates, HOIL-1 has been linked with antiviral signaling, iron and xenobiotic metabolism, cell death, and cancer. HOIL-1 deficiency in humans leads to myopathy, amylopectinosis, auto-inflammation, and immunodeficiency associated with an increased frequency of bacterial infections. HOIL-1-deficient mice exhibit amylopectin-like deposits in the myocardium, pathogen-specific immunodeficiency, but minimal signs of hyper-inflammation. This review summarizes current knowledge on the mechanism of action of HOIL-1 and highlights recent advances regarding its role in health and disease.
- Keywords
- HOIL-1, cancer, immunity, metabolism, RBCK1, ubiquitination, NF-KAPPA-B, PROTEIN-KINASE-C, CHAIN ASSEMBLY COMPLEX, ESTROGEN-RECEPTOR-ALPHA, PREGNANE X RECEPTOR, ZINC-FINGER 7, POLYUBIQUITIN CHAINS, INTERACTING PROTEIN, ANTIVIRAL RESPONSE, IMMUNE REGULATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-6885325
- Chicago
- Elton, Lynn, Isabelle Carpentier, Kelly Verhelst, Jens Staal, and Rudi Beyaert. 2015. “The Multifaceted Role of the E3 Ubiquitin Ligase HOIL-1: Beyond Linear Ubiquitination.” Immunological Reviews 266 (1): 208–221.
- APA
- Elton, L., Carpentier, I., Verhelst, K., Staal, J., & Beyaert, R. (2015). The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination. IMMUNOLOGICAL REVIEWS, 266(1), 208–221.
- Vancouver
- 1.Elton L, Carpentier I, Verhelst K, Staal J, Beyaert R. The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination. IMMUNOLOGICAL REVIEWS. 2015;266(1):208–21.
- MLA
- Elton, Lynn et al. “The Multifaceted Role of the E3 Ubiquitin Ligase HOIL-1: Beyond Linear Ubiquitination.” IMMUNOLOGICAL REVIEWS 266.1 (2015): 208–221. Print.
@article{6885325,
abstract = {Ubiquitination controls and fine-tunes many signaling processes driving immunity, inflammation, and cancer. The E3 ubiquitin ligase HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) is increasingly implicated in different signaling pathways and plays a vital role in immune regulation. HOIL-1 co operates with the E3 ubiquitin ligase HOIP (HOIL-1 interacting protein) to modify specific nuclear factor-B (NF-B) signaling proteins with linear M1-linked polyubiquitin chains. In addition, through its ability to also add K48-linked polyubiquitin chains to specific substrates, HOIL-1 has been linked with antiviral signaling, iron and xenobiotic metabolism, cell death, and cancer. HOIL-1 deficiency in humans leads to myopathy, amylopectinosis, auto-inflammation, and immunodeficiency associated with an increased frequency of bacterial infections. HOIL-1-deficient mice exhibit amylopectin-like deposits in the myocardium, pathogen-specific immunodeficiency, but minimal signs of hyper-inflammation. This review summarizes current knowledge on the mechanism of action of HOIL-1 and highlights recent advances regarding its role in health and disease.},
author = {Elton, Lynn and Carpentier, Isabelle and Verhelst, Kelly and Staal, Jens and Beyaert, Rudi},
issn = {0105-2896},
journal = {IMMUNOLOGICAL REVIEWS},
keywords = {HOIL-1,cancer,immunity,metabolism,RBCK1,ubiquitination,NF-KAPPA-B,PROTEIN-KINASE-C,CHAIN ASSEMBLY COMPLEX,ESTROGEN-RECEPTOR-ALPHA,PREGNANE X RECEPTOR,ZINC-FINGER 7,POLYUBIQUITIN CHAINS,INTERACTING PROTEIN,ANTIVIRAL RESPONSE,IMMUNE REGULATION},
language = {eng},
number = {1},
pages = {208--221},
title = {The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination},
url = {http://dx.doi.org/10.1111/imr.12307},
volume = {266},
year = {2015},
}
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