@article{6885325,
  abstract     = {Ubiquitination controls and fine-tunes many signaling processes driving immunity, inflammation, and cancer. The E3 ubiquitin ligase HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) is increasingly implicated in different signaling pathways and plays a vital role in immune regulation. HOIL-1 co operates with the E3 ubiquitin ligase HOIP (HOIL-1 interacting protein) to modify specific nuclear factor-B (NF-B) signaling proteins with linear M1-linked polyubiquitin chains. In addition, through its ability to also add K48-linked polyubiquitin chains to specific substrates, HOIL-1 has been linked with antiviral signaling, iron and xenobiotic metabolism, cell death, and cancer. HOIL-1 deficiency in humans leads to myopathy, amylopectinosis, auto-inflammation, and immunodeficiency associated with an increased frequency of bacterial infections. HOIL-1-deficient mice exhibit amylopectin-like deposits in the myocardium, pathogen-specific immunodeficiency, but minimal signs of hyper-inflammation. This review summarizes current knowledge on the mechanism of action of HOIL-1 and highlights recent advances regarding its role in health and disease.},
  author       = {Elton, Lynn and Carpentier, Isabelle and Verhelst, Kelly and Staal, Jens and Beyaert, Rudi},
  issn         = {0105-2896},
  journal      = {IMMUNOLOGICAL REVIEWS},
  keywords     = {HOIL-1,cancer,immunity,metabolism,RBCK1,ubiquitination,NF-KAPPA-B,PROTEIN-KINASE-C,CHAIN ASSEMBLY COMPLEX,ESTROGEN-RECEPTOR-ALPHA,PREGNANE X RECEPTOR,ZINC-FINGER 7,POLYUBIQUITIN CHAINS,INTERACTING PROTEIN,ANTIVIRAL RESPONSE,IMMUNE REGULATION},
  language     = {eng},
  number       = {1},
  pages        = {208--221},
  title        = {The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination},
  url          = {http://dx.doi.org/10.1111/imr.12307},
  volume       = {266},
  year         = {2015},
}

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