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Proteolytic processing of interleukin-1 family cytokines: variations on a common theme

Inna Afonina UGent, Christina Müller, Seamus J Martin and Rudi Beyaert UGent (2015) IMMUNITY. 42(6). p.991-1004
abstract
Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 family members share a broadly similar domain organization and receptor signaling pathways. Another striking similarity between IL-1 family members is the requirement for proteolytic processing in order to unlock their full biological potential. Although much emphasis has been put on the role of caspase-1, another emerging theme is the involvement of neutrophil-and mast cell-derived proteases in IL-1 family cytokine processing. Elucidating the regulation of IL-1 family members by proteolytic processing is of great interest for understanding inflammation and immunity. Here, we review the identity of the proteases involved in the proteolytic processing of IL-1 family cytokines and the therapeutic implications in inflammatory disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
ALLERGIC AIRWAY INFLAMMATION, GENERALIZED PUSTULAR PSORIASIS, MAST-CELL CHYMASE, GAMMA-INDUCING FACTOR, GRANZYME-B, CONVERTING-ENZYME, STERILE INFLAMMATION, HUMAN KERATINOCYTES, MICE DEFICIENT, IN-VIVO
journal title
IMMUNITY
Immunity
volume
42
issue
6
pages
991 - 1004
Web of Science type
Review
Web of Science id
000356362800007
JCR category
IMMUNOLOGY
JCR impact factor
24.082 (2015)
JCR rank
3/150 (2015)
JCR quartile
1 (2015)
ISSN
1074-7613
DOI
10.1016/j.immuni.2015.06.003
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
6885311
handle
http://hdl.handle.net/1854/LU-6885311
date created
2015-07-27 16:41:34
date last changed
2016-12-19 15:45:51
@article{6885311,
  abstract     = {Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 family members share a broadly similar domain organization and receptor signaling pathways. Another striking similarity between IL-1 family members is the requirement for proteolytic processing in order to unlock their full biological potential. Although much emphasis has been put on the role of caspase-1, another emerging theme is the involvement of neutrophil-and mast cell-derived proteases in IL-1 family cytokine processing. Elucidating the regulation of IL-1 family members by proteolytic processing is of great interest for understanding inflammation and immunity. Here, we review the identity of the proteases involved in the proteolytic processing of IL-1 family cytokines and the therapeutic implications in inflammatory disease.},
  author       = {Afonina, Inna and M{\"u}ller, Christina and Martin, Seamus J and Beyaert, Rudi},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {ALLERGIC AIRWAY INFLAMMATION,GENERALIZED PUSTULAR PSORIASIS,MAST-CELL CHYMASE,GAMMA-INDUCING FACTOR,GRANZYME-B,CONVERTING-ENZYME,STERILE INFLAMMATION,HUMAN KERATINOCYTES,MICE DEFICIENT,IN-VIVO},
  language     = {eng},
  number       = {6},
  pages        = {991--1004},
  title        = {Proteolytic processing of interleukin-1 family cytokines: variations on a common theme},
  url          = {http://dx.doi.org/10.1016/j.immuni.2015.06.003},
  volume       = {42},
  year         = {2015},
}

Chicago
Afonina, Inna, Christina Müller, Seamus J Martin, and Rudi Beyaert. 2015. “Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme.” Immunity 42 (6): 991–1004.
APA
Afonina, I., Müller, C., Martin, S. J., & Beyaert, R. (2015). Proteolytic processing of interleukin-1 family cytokines: variations on a common theme. IMMUNITY, 42(6), 991–1004.
Vancouver
1.
Afonina I, Müller C, Martin SJ, Beyaert R. Proteolytic processing of interleukin-1 family cytokines: variations on a common theme. IMMUNITY. 2015;42(6):991–1004.
MLA
Afonina, Inna, Christina Müller, Seamus J Martin, et al. “Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme.” IMMUNITY 42.6 (2015): 991–1004. Print.