Ghent University Academic Bibliography

Advanced

What kind of prostate cancers do we miss on multiparametric magnetic resonance imaging?

Pieter De Visschere, Leslie Naesens, Louis Libbrecht, Charles Van Praet UGent, Nicolaas Lumen UGent, VALERIE FONTEYNE, EVA PATTYN and Geert Villeirs UGent (2016) EUROPEAN RADIOLOGY. 26(4). p.1098-1107
abstract
Objective: To analyse the characteristics of prostate cancers (PrCa) detected following negative multiparametric magnetic resonance imaging (mpMRI). Materials and methods: Eight hundred and thirty patients with elevated prostate-specific antigen (mean 11.9 mu g/l) underwent mpMRI of the prostate at 1.5 Tesla with endorectal coil. The characteristics of all PrCa detected within 2 years after a negative mpMRI were analysed. Primary Gleason grade 4 or any grade 5 PrCa were considered high-grade (HG), Gleason score 3 + 4 intermediate grade (IG) and Gleason score a parts per thousand currency sign3 + 3 low-grade (LG). Tumour size was considered 'small' when < 1 cm on radical prostatectomy specimen or limited to a parts per thousand currency sign2 cores on prostate biopsy. Results: mpMRI was negative in 391 patients (47.1 %). In 124 patients (31.7 %) PrCa was detected within 2 years. Eighty-four (67.7 %) were LG, 22 (17.7 %) IG and 18 (14.5 %) HG. 119 (96.0 %) of the missed PrCa were organ-confined. The negative predictive value was 95.4 % (373/391) for HG PrCa. Among the 18 missed HG PrCa, 15 (83.3 %) were organ-confined and 12 (66.6 %) were small. Conclusion: The majority of missed tumours on mpMRI were low grade and organ-confined. In patients with elevated PSA and a negative mpMRI, consideration could be given to continued surveillance rather than immediate biopsy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Prostatic neoplasms, Prostate, Magnetic resonance imaging, Magnetic resonance spectroscopy, Diffusion magnetic resonance imaging, CLINICAL-SIGNIFICANCE, TUMOR VOLUME, FOLLOW-UP, MRI, BIOPSY, MEN, DIAGNOSIS, CARCINOMA, ACCURACY, ABSENCE
journal title
EUROPEAN RADIOLOGY
Eur. Radiol.
volume
26
issue
4
pages
1098 - 1107
Web of Science type
Article
Web of Science id
000371625100021
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
3.967 (2016)
JCR rank
15/126 (2016)
JCR quartile
1 (2016)
ISSN
0938-7994
DOI
10.1007/s00330-015-3894-x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
6884501
handle
http://hdl.handle.net/1854/LU-6884501
date created
2015-07-20 18:14:45
date last changed
2016-12-19 15:48:38
@article{6884501,
  abstract     = {Objective: To analyse the characteristics of prostate cancers (PrCa) detected following negative multiparametric magnetic resonance imaging (mpMRI). 
Materials and methods: Eight hundred and thirty patients with elevated prostate-specific antigen (mean 11.9 mu g/l) underwent mpMRI of the prostate at 1.5 Tesla with endorectal coil. The characteristics of all PrCa detected within 2 years after a negative mpMRI were analysed. Primary Gleason grade 4 or any grade 5 PrCa were considered high-grade (HG), Gleason score 3 + 4 intermediate grade (IG) and Gleason score a parts per thousand currency sign3 + 3 low-grade (LG). Tumour size was considered 'small' when {\textlangle} 1 cm on radical prostatectomy specimen or limited to a parts per thousand currency sign2 cores on prostate biopsy. 
Results: mpMRI was negative in 391 patients (47.1 \%). In 124 patients (31.7 \%) PrCa was detected within 2 years. Eighty-four (67.7 \%) were LG, 22 (17.7 \%) IG and 18 (14.5 \%) HG. 119 (96.0 \%) of the missed PrCa were organ-confined. The negative predictive value was 95.4 \% (373/391) for HG PrCa. Among the 18 missed HG PrCa, 15 (83.3 \%) were organ-confined and 12 (66.6 \%) were small. 
Conclusion: The majority of missed tumours on mpMRI were low grade and organ-confined. In patients with elevated PSA and a negative mpMRI, consideration could be given to continued surveillance rather than immediate biopsy.},
  author       = {De Visschere, Pieter and Naesens, Leslie and Libbrecht, Louis and Van Praet, Charles and Lumen, Nicolaas and FONTEYNE, VALERIE and PATTYN, EVA and Villeirs, Geert},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keyword      = {Prostatic neoplasms,Prostate,Magnetic resonance imaging,Magnetic resonance spectroscopy,Diffusion magnetic resonance imaging,CLINICAL-SIGNIFICANCE,TUMOR VOLUME,FOLLOW-UP,MRI,BIOPSY,MEN,DIAGNOSIS,CARCINOMA,ACCURACY,ABSENCE},
  language     = {eng},
  number       = {4},
  pages        = {1098--1107},
  title        = {What kind of prostate cancers do we miss on multiparametric magnetic resonance imaging?},
  url          = {http://dx.doi.org/10.1007/s00330-015-3894-x},
  volume       = {26},
  year         = {2016},
}

Chicago
De Visschere, Pieter, Leslie Naesens, Louis Libbrecht, Charles Van Praet, Nicolaas Lumen, Valérie Fonteyne, EVA PATTYN, and Geert Villeirs. 2016. “What Kind of Prostate Cancers Do We Miss on Multiparametric Magnetic Resonance Imaging?” European Radiology 26 (4): 1098–1107.
APA
De Visschere, Pieter, Naesens, L., Libbrecht, L., Van Praet, C., Lumen, N., Fonteyne, V., PATTYN, E., et al. (2016). What kind of prostate cancers do we miss on multiparametric magnetic resonance imaging? EUROPEAN RADIOLOGY, 26(4), 1098–1107.
Vancouver
1.
De Visschere P, Naesens L, Libbrecht L, Van Praet C, Lumen N, Fonteyne V, et al. What kind of prostate cancers do we miss on multiparametric magnetic resonance imaging? EUROPEAN RADIOLOGY. 2016;26(4):1098–107.
MLA
De Visschere, Pieter, Leslie Naesens, Louis Libbrecht, et al. “What Kind of Prostate Cancers Do We Miss on Multiparametric Magnetic Resonance Imaging?” EUROPEAN RADIOLOGY 26.4 (2016): 1098–1107. Print.