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Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art

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Abstract
Mucositis is a major oncological problem. The entire gastrointestinal and genitourinary tract and also other mucosal surfaces can be affected in recipients of radiotherapy, and/or chemotherapy. Major progress has been made in recent years in understanding the mechanisms of oral and small intestinal mucositis, which appears to be more prominent than colonic damage. This progress is largely due to the development of representative laboratory animal models of mucositis. This review focuses on the development and establishment of the Dark Agouti rat mammary adenocarcinoma model by the Mucositis Research Group of the University of Adelaide over the past 20 years to characterize the mechanisms underlying methotrexate- ,5-fluorouracil-, and irinotecan-induced mucositis. It also aims to summarize the results from studies using different animal model systems to identify new molecular and cellular markers of mucositis.
Keywords
mucositis, Rat, methotrexate, 5-fluorouracil, irinotecan, chemotherapy, PLATELET-ACTIVATING-FACTOR, METHOTREXATE-TREATED RATS, HEPATOCYTE GROWTH-FACTOR, INTESTINAL TREFOIL FACTOR, MURINE GASTROINTESTINAL MUCOSA, ACUTE LYMPHOBLASTIC-LEUKEMIA, ALIMENTARY-TRACT MUCOSITIS, DAMAGE-INDUCED APOPTOSIS, INDUCED GASTRIC INJURY, TUMOR-BEARING RATS

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Chicago
Vanhoecke, Barbara, Emma Bateman, Bronwen Mayo, Eline Vanlancker, Andrea Stringer, Daniel Thorpe, and Dorothy Keefe. 2015. “Dark Agouti Rat Model of Chemotherapy-induced Mucositis: Establishment and Current State of the Art.” Experimental Biology and Medicine 240 (6): 725–741.
APA
Vanhoecke, B., Bateman, E., Mayo, B., Vanlancker, E., Stringer, A., Thorpe, D., & Keefe, D. (2015). Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art. EXPERIMENTAL BIOLOGY AND MEDICINE, 240(6), 725–741.
Vancouver
1.
Vanhoecke B, Bateman E, Mayo B, Vanlancker E, Stringer A, Thorpe D, et al. Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art. EXPERIMENTAL BIOLOGY AND MEDICINE. 2015;240(6):725–41.
MLA
Vanhoecke, Barbara et al. “Dark Agouti Rat Model of Chemotherapy-induced Mucositis: Establishment and Current State of the Art.” EXPERIMENTAL BIOLOGY AND MEDICINE 240.6 (2015): 725–741. Print.
@article{6871566,
  abstract     = {Mucositis is a major oncological problem. The entire gastrointestinal and genitourinary tract and also other mucosal surfaces can be affected in recipients of radiotherapy, and/or chemotherapy. Major progress has been made in recent years in understanding the mechanisms of oral and small intestinal mucositis, which appears to be more prominent than colonic damage. This progress is largely due to the development of representative laboratory animal models of mucositis. This review focuses on the development and establishment of the Dark Agouti rat mammary adenocarcinoma model by the Mucositis Research Group of the University of Adelaide over the past 20 years to characterize the mechanisms underlying methotrexate- ,5-fluorouracil-, and irinotecan-induced mucositis. It also aims to summarize the results from studies using different animal model systems to identify new molecular and cellular markers of mucositis.},
  author       = {Vanhoecke, Barbara and Bateman, Emma and Mayo, Bronwen and Vanlancker, Eline and Stringer, Andrea and Thorpe, Daniel and Keefe, Dorothy},
  issn         = {1535-3702},
  journal      = {EXPERIMENTAL BIOLOGY AND MEDICINE},
  keywords     = {mucositis,Rat,methotrexate,5-fluorouracil,irinotecan,chemotherapy,PLATELET-ACTIVATING-FACTOR,METHOTREXATE-TREATED RATS,HEPATOCYTE GROWTH-FACTOR,INTESTINAL TREFOIL FACTOR,MURINE GASTROINTESTINAL MUCOSA,ACUTE LYMPHOBLASTIC-LEUKEMIA,ALIMENTARY-TRACT MUCOSITIS,DAMAGE-INDUCED APOPTOSIS,INDUCED GASTRIC INJURY,TUMOR-BEARING RATS},
  language     = {eng},
  number       = {6},
  pages        = {725--741},
  title        = {Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art},
  url          = {http://dx.doi.org/10.1177/1535370215581309},
  volume       = {240},
  year         = {2015},
}

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