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Screening for HLA antibodies in plateletpheresis donors with a history of transfusion or pregnancy

(2014) TRANSFUSION. 54(12). p.3036-3042
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Abstract
BACKGROUND : Transfusion-related acute lung injury(TRALI) is known as a life-threatening complication oftransfusion. HLA and HNA antibodies have been asso-ciated with the immune pathway of TRALI. Sincedonors with a history of transfusion and/or pregnancyare presumed to have an increased risk of carryingsuch antibodies, we investigated the association of ahistory of transfusion or pregnancy with the occurrenceof HLA alloimmunization in our donor population. STUDY DESIGN AND METHODS : A total of 1018female plateletpheresis donors and maleplateletpheresis donors with a history of transfusionwere enrolled in the study. Included donors were sys-tematically screened, using Luminex technology, foranti-HLA Class I and II. The association of donor historywith HLA alloimmunization status was analyzed. RESULTS : The overall alloimmunization rate was20.2%. In 0.0% of the nulliparous transfused femaledonors and in 1.3% of the transfused male donors, anti-HLA were detected. Thirty-one percent of the parouswomen versus 4.2% of the nulliparous women screenedpositive for anti-HLA. The rate of HLA alloimmunizationincreased with parity. CONCLUSION : Our data indicate that a history oftransfusion is a minor risk factor for immunizationagainst HLA antigens. In contrast, former pregnanciesconstitute a major risk factor for the development ofHLA antibodies. Since HLA alloimmunization rateincreases with parity, TRALI risk reduction measuresshould focus on this particular donor population.Repeated testing of female plateletpheresis donors aftereach pregnancy is implemented in our blood service.
Keywords
RISK, PLASMA, STRATEGY, PREVALENCE, RETROSPECTIVE COHORT, POSTPARTUM HEMORRHAGE, BLOOD-DONORS, AMERICAN-RED-CROSS, CLASS-II ANTIBODIES, ACUTE LUNG INJURY

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Chicago
De Clippel, Dorien, Martine Baeten, Anneleen Torfs, Marie-Paule Emonds, Hendrik Feys, Philippe Vandekerckhove, and Veerle Compernolle. 2014. “Screening for HLA Antibodies in Plateletpheresis Donors with a History of Transfusion or Pregnancy.” Transfusion 54 (12): 3036–3042.
APA
De Clippel, D., Baeten, M., Torfs, A., Emonds, M.-P., Feys, H., Vandekerckhove, P., & Compernolle, V. (2014). Screening for HLA antibodies in plateletpheresis donors with a history of transfusion or pregnancy. TRANSFUSION, 54(12), 3036–3042.
Vancouver
1.
De Clippel D, Baeten M, Torfs A, Emonds M-P, Feys H, Vandekerckhove P, et al. Screening for HLA antibodies in plateletpheresis donors with a history of transfusion or pregnancy. TRANSFUSION. 2014;54(12):3036–42.
MLA
De Clippel, Dorien et al. “Screening for HLA Antibodies in Plateletpheresis Donors with a History of Transfusion or Pregnancy.” TRANSFUSION 54.12 (2014): 3036–3042. Print.
@article{6864540,
  abstract     = {BACKGROUND : Transfusion-related acute lung injury(TRALI) is known as a life-threatening complication oftransfusion. HLA and HNA antibodies have been asso-ciated with the immune pathway of TRALI. Sincedonors with a history of transfusion and/or pregnancyare presumed to have an increased risk of carryingsuch antibodies, we investigated the association of ahistory of transfusion or pregnancy with the occurrenceof HLA alloimmunization in our donor population.
STUDY DESIGN AND METHODS :  A total of 1018female plateletpheresis donors and maleplateletpheresis donors with a history of transfusionwere enrolled in the study. Included donors were sys-tematically screened, using Luminex technology, foranti-HLA Class I and II. The association of donor historywith HLA alloimmunization status was analyzed.
RESULTS :  The overall alloimmunization rate was20.2\%. In 0.0\% of the nulliparous transfused femaledonors and in 1.3\% of the transfused male donors, anti-HLA were detected. Thirty-one percent of the parouswomen versus 4.2\% of the nulliparous women screenedpositive for anti-HLA. The rate of HLA alloimmunizationincreased with parity.
CONCLUSION :  Our data indicate that a history oftransfusion is a minor risk factor for immunizationagainst HLA antigens. In contrast, former pregnanciesconstitute a major risk factor for the development ofHLA antibodies. Since HLA alloimmunization rateincreases with parity, TRALI risk reduction measuresshould focus on this particular donor population.Repeated testing of female plateletpheresis donors aftereach pregnancy is implemented in our blood service.},
  author       = {De Clippel, Dorien and Baeten, Martine and Torfs, Anneleen and Emonds, Marie-Paule and Feys, Hendrik and Vandekerckhove, Philippe and Compernolle, Veerle},
  issn         = {0041-1132},
  journal      = {TRANSFUSION},
  language     = {eng},
  number       = {12},
  pages        = {3036--3042},
  title        = {Screening for HLA antibodies in plateletpheresis donors with a history of transfusion or pregnancy},
  url          = {http://dx.doi.org/10.1111/trf.12727},
  volume       = {54},
  year         = {2014},
}

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