Advanced search
1 file | 278.24 KB Add to list

Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA²LEN survey

(2014) ALLERGY. 69(5). p.643-651
Author
Organization
Abstract
Background : Geographical variation in the prevalence of sensitization to aeroallergens may reflect differences in exposure to risk factors such as having older siblings, being raised on a farm or other unidentified exposures. Objective : We wanted to measure geographical variation in skin prick test positivity and assess whether it was explained by differences in family size and/or farm exposure. We also compared prevalence in younger and older subjects. Methods : Within the Global Allergy and Asthma European Network (GA(2)LEN) survey, we measured the prevalence of skin prick positivity to a panel of allergens, and geometric mean serum total immunoglobulin E (IgE), in 3451 participants aged 18-75years in 13 areas of Europe. Estimated prevalence was standardized to account for study design. We compared prevalence estimates in younger and older subjects and further adjusted for age, gender, smoking history, farm exposure, number of older siblings and body mass index (BMI). Results : Skin prick test positivity to any one of the measured allergens varied within Europe from 31.4% to 52.9%. Prevalence of sensitization to single allergens also varied. Variation in serum total IgE was less marked. Younger participants had higher skin prick sensitivity prevalence, but not total IgE, than older participants. Geographical variation remained even after adjustment for confounders. Conclusion : Geographical variation in the prevalence of skin prick test positivity in Europe is unlikely to be explained by geographical variation in gender, age, smoking history, farm exposure, family size and BMI. Higher prevalence in younger, compared to older, adults may reflect cohort-associated increases in sensitization or the influence of ageing on immune or tissue responses.
Keywords
Global Allergy and Asthma European Network, prevalence, Europe, skin prick tests, geographical variation, total immunoglobulin E, RESPIRATORY HEALTH SURVEY, SKIN PRICK TESTS, SERUM IGE, CHRONIC RHINOSINUSITIS, POPULATION-SAMPLE, IMMUNOGLOBULIN-E, TEST REACTIVITY, BODY-MASS, SURVEY I, SMOKING

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 278.24 KB

Citation

Please use this url to cite or link to this publication:

MLA
Newson, RB et al. “Geographical Variation in the Prevalence of Sensitization to Common Aeroallergens in Adults: The GA2LEN Survey.” ALLERGY 69.5 (2014): 643–651. Print.
APA
Newson, R., van Ree, R., Forsberg, B., Janson, C., Lötvall, J., Dahlén, S.-E., Toskala, E., et al. (2014). Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey. ALLERGY, 69(5), 643–651.
Chicago author-date
Newson, RB, R van Ree, B Forsberg, C Janson, J Lötvall, S-E Dahlén, EM Toskala, et al. 2014. “Geographical Variation in the Prevalence of Sensitization to Common Aeroallergens in Adults: The GA2LEN Survey.” Allergy 69 (5): 643–651.
Chicago author-date (all authors)
Newson, RB, R van Ree, B Forsberg, C Janson, J Lötvall, S-E Dahlén, EM Toskala, J Baelum, GM Brożek, L Kasper, ML Kowalski, PH Howarth, WJ Fokkens, Claus Bachert, T Keil, U Krämer, J Bislimovska, M Gjomarkaj, C Loureiro, PGJ Burney, and D Jarvis. 2014. “Geographical Variation in the Prevalence of Sensitization to Common Aeroallergens in Adults: The GA2LEN Survey.” Allergy 69 (5): 643–651.
Vancouver
1.
Newson R, van Ree R, Forsberg B, Janson C, Lötvall J, Dahlén S-E, et al. Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey. ALLERGY. 2014;69(5):643–51.
IEEE
[1]
R. Newson et al., “Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey,” ALLERGY, vol. 69, no. 5, pp. 643–651, 2014.
@article{6863537,
  abstract     = {Background : Geographical variation in the prevalence of sensitization to aeroallergens may reflect differences in exposure to risk factors such as having older siblings, being raised on a farm or other unidentified exposures. 
Objective : We wanted to measure geographical variation in skin prick test positivity and assess whether it was explained by differences in family size and/or farm exposure. We also compared prevalence in younger and older subjects. 
Methods : Within the Global Allergy and Asthma European Network (GA(2)LEN) survey, we measured the prevalence of skin prick positivity to a panel of allergens, and geometric mean serum total immunoglobulin E (IgE), in 3451 participants aged 18-75years in 13 areas of Europe. Estimated prevalence was standardized to account for study design. We compared prevalence estimates in younger and older subjects and further adjusted for age, gender, smoking history, farm exposure, number of older siblings and body mass index (BMI). 
Results : Skin prick test positivity to any one of the measured allergens varied within Europe from 31.4% to 52.9%. Prevalence of sensitization to single allergens also varied. Variation in serum total IgE was less marked. Younger participants had higher skin prick sensitivity prevalence, but not total IgE, than older participants. Geographical variation remained even after adjustment for confounders. 
Conclusion : Geographical variation in the prevalence of skin prick test positivity in Europe is unlikely to be explained by geographical variation in gender, age, smoking history, farm exposure, family size and BMI. Higher prevalence in younger, compared to older, adults may reflect cohort-associated increases in sensitization or the influence of ageing on immune or tissue responses.},
  author       = {Newson, RB and van Ree, R and Forsberg, B and Janson, C and Lötvall, J and Dahlén, S-E and Toskala, EM and Baelum, J and Brożek, GM and Kasper, L and Kowalski, ML and Howarth, PH and Fokkens, WJ and Bachert, Claus and Keil, T and Krämer, U and Bislimovska, J and Gjomarkaj, M and Loureiro, C and Burney, PGJ and Jarvis, D},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {Global Allergy and Asthma European Network,prevalence,Europe,skin prick tests,geographical variation,total immunoglobulin E,RESPIRATORY HEALTH SURVEY,SKIN PRICK TESTS,SERUM IGE,CHRONIC RHINOSINUSITIS,POPULATION-SAMPLE,IMMUNOGLOBULIN-E,TEST REACTIVITY,BODY-MASS,SURVEY I,SMOKING},
  language     = {eng},
  number       = {5},
  pages        = {643--651},
  title        = {Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA²LEN survey},
  url          = {http://dx.doi.org/10.1111/all.12397},
  volume       = {69},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: