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Oncological outcomes of totally intracorporeal robot-assisted radical cystectomy: results from the ERUS scientific working group

(2015) JOURNAL OF UROLOGY. 193(4, suppl.). p.e857-e857
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Abstract
ABSTRACT: INTRODUCTION AND OBJECTIVES Data on the oncological outcomes in patients undergoing robot-assisted radical cystectomy (RARC) is limited. Globally extracorporeal urinary diversion following RARC remains the most common approach despite potential advantages of a completely minimally invasive approach. We report oncological outcomes and associated prognostic factors from a multi-institutional European database focusing on the centres performing totally intracorporeal RARC. METHODS In the ERUS scientific working group database, 467 patients underwent totally intracorporeal RARC for bladder cancer between 2003 and 2014. Clinical and pathological data at the time of the latest follow-up was reviewed. Recurrence free survival (RFS), cancer specific survival (CSS) and overall survival (OS) were the outcomes of interest and evaluated using the Kaplan Meier estimator. Multivariable Cox regression analysis was performed to identify factors associated with outcomes of interest. RESULTS Mean age was 67 years, 80% were men. 384 (82%) patients were alive at the time of the analysis. Median follow-up was 17.9 months (range 1-130 months). 87 patients (19%) had undergone surgery 3 or more years' ago. Median follow-up of patients alive was 16 months. 31% patients had pathological non organ-confined disease. Positive surgical margins were present in 5%; median lymph node yield was 18 with 19% of patients having positive lymph nodes. The 3-year RFS, CSS and OS were 73%, 75% and 73% respectively. On multivariable analysis, non-organ confined disease was found to impact RFS, CSS and OS (HR 4.0, 4.3 and 4.2 respectively) and LN positive disease was associated with poorer RFS (HR 2.1). Histopathology stage pT0 was a positive prognostic indicator associated with better RFS, CSS and OS (HR 0.15, 0.16 and 0.74 respectively). CONCLUSIONS This is the largest reported multi-institutional cohort of totally intracorporeal RARC showing acceptable medium term survival outcomes comparable to open radical cystectomy series. The ERUS scientific working group database indicates that a totally intracorporeal approach is replicable.

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MLA
Collins, Justin, et al. “Oncological Outcomes of Totally Intracorporeal Robot-Assisted Radical Cystectomy: Results from the ERUS Scientific Working Group.” JOURNAL OF UROLOGY, vol. 193, no. 4, suppl., 2015, pp. e857–e857, doi:10.1016/j.juro.2015.02.2502.
APA
Collins, J., Hosseini, A., Schumacher, M., Canda, A., Wijburg, C., Schwentner, C., … Wiklund, P. (2015). Oncological outcomes of totally intracorporeal robot-assisted radical cystectomy: results from the ERUS scientific working group. JOURNAL OF UROLOGY, 193(4, suppl.), e857–e857. https://doi.org/10.1016/j.juro.2015.02.2502
Chicago author-date
Collins, Justin, Abolfazl Hosseini, Martin Schumacher, Abdullah Canda, Carl Wijburg, Christian Schwentner, Arnulf Stenzl, et al. 2015. “Oncological Outcomes of Totally Intracorporeal Robot-Assisted Radical Cystectomy: Results from the ERUS Scientific Working Group.” In JOURNAL OF UROLOGY, 193:e857–e857. https://doi.org/10.1016/j.juro.2015.02.2502.
Chicago author-date (all authors)
Collins, Justin, Abolfazl Hosseini, Martin Schumacher, Abdullah Canda, Carl Wijburg, Christian Schwentner, Arnulf Stenzl, Derya Balbay, Karel Decaestecker, Sebastian Edeling, Sasa Pokupic, Khurshid Guru, Alexander Mottrie, and Peter Wiklund. 2015. “Oncological Outcomes of Totally Intracorporeal Robot-Assisted Radical Cystectomy: Results from the ERUS Scientific Working Group.” In JOURNAL OF UROLOGY, 193:e857–e857. doi:10.1016/j.juro.2015.02.2502.
Vancouver
1.
Collins J, Hosseini A, Schumacher M, Canda A, Wijburg C, Schwentner C, et al. Oncological outcomes of totally intracorporeal robot-assisted radical cystectomy: results from the ERUS scientific working group. In: JOURNAL OF UROLOGY. 2015. p. e857–e857.
IEEE
[1]
J. Collins et al., “Oncological outcomes of totally intracorporeal robot-assisted radical cystectomy: results from the ERUS scientific working group,” in JOURNAL OF UROLOGY, New Orleans, LA, USA, 2015, vol. 193, no. 4, suppl., pp. e857–e857.
@inproceedings{6862938,
  abstract     = {{ABSTRACT: INTRODUCTION AND OBJECTIVES Data on the oncological outcomes in patients undergoing robot-assisted radical cystectomy (RARC) is limited. Globally extracorporeal urinary diversion following RARC remains the most common approach despite potential advantages of a completely minimally invasive approach. We report oncological outcomes and associated prognostic factors from a multi-institutional European database focusing on the centres performing totally intracorporeal RARC. METHODS In the ERUS scientific working group database, 467 patients underwent totally intracorporeal RARC for bladder cancer between 2003 and 2014. Clinical and pathological data at the time of the latest follow-up was reviewed. Recurrence free survival (RFS), cancer specific survival (CSS) and overall survival (OS) were the outcomes of interest and evaluated using the Kaplan Meier estimator. Multivariable Cox regression analysis was performed to identify factors associated with outcomes of interest. RESULTS Mean age was 67 years, 80% were men. 384 (82%) patients were alive at the time of the analysis. Median follow-up was 17.9 months (range 1-130 months). 87 patients (19%) had undergone surgery 3 or more years' ago. Median follow-up of patients alive was 16 months. 31% patients had pathological non organ-confined disease. Positive surgical margins were present in 5%; median lymph node yield was 18 with 19% of patients having positive lymph nodes. The 3-year RFS, CSS and OS were 73%, 75% and 73% respectively. On multivariable analysis, non-organ confined disease was found to impact RFS, CSS and OS (HR 4.0, 4.3 and 4.2 respectively) and LN positive disease was associated with poorer RFS (HR 2.1). Histopathology stage pT0 was a positive prognostic indicator associated with better RFS, CSS and OS (HR 0.15, 0.16 and 0.74 respectively). CONCLUSIONS This is the largest reported multi-institutional cohort of totally intracorporeal RARC showing acceptable medium term survival outcomes comparable to open radical cystectomy series. The ERUS scientific working group database indicates that a totally intracorporeal approach is replicable.}},
  articleno    = {{abstract MP67-19}},
  author       = {{Collins, Justin and Hosseini, Abolfazl and Schumacher, Martin and Canda, Abdullah and Wijburg, Carl and Schwentner, Christian and Stenzl, Arnulf and Balbay, Derya and Decaestecker, Karel and Edeling, Sebastian and Pokupic, Sasa and Guru, Khurshid and Mottrie, Alexander and Wiklund, Peter}},
  booktitle    = {{JOURNAL OF UROLOGY}},
  issn         = {{0022-5347}},
  language     = {{eng}},
  location     = {{New Orleans, LA, USA}},
  number       = {{4, suppl.}},
  pages        = {{abstract MP67-19:e857--abstract MP67-19:e857}},
  title        = {{Oncological outcomes of totally intracorporeal robot-assisted radical cystectomy: results from the ERUS scientific working group}},
  url          = {{http://doi.org/10.1016/j.juro.2015.02.2502}},
  volume       = {{193}},
  year         = {{2015}},
}

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