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Thoracic aortic rupture and aortopulmonary fistulation in the Friesian horse : histomorphologic characterization

Margreet Ploeg, Veronique Saey, Catherine Delesalle UGent, A Gröne, Richard Ducatelle UGent, Marco de Bruijn, Willem Back UGent, PR van Weeren, Gunther van Loon UGent and Koen Chiers UGent (2015) VETERINARY PATHOLOGY. 52(1). p.152-159
abstract
Aortic rupture in horses is a rare condition. Although it is relatively common in the Friesian breed, only limited histopathologic information is available. Twenty Friesian horses (1-10 years old) were diagnosed with aortic rupture by postmortem examination. Ruptured aortic walls were analyzed with histology and immunohistochemistry. Based on the histologic and immunohistochemical findings, these cases were divided into 3 groups: acute (n = 4, 20%), subacute (n = 8, 40%), and chronic (n = 8, 40%). Features common to samples from horses in all groups included accumulation of mucoid material; disorganization and fragmentation of the elastic laminae; aortic medial smooth muscle hypertrophy; and medial necrosis of varying degrees, ranging from mild and patchy in the acute cases to severe midzonal necrosis in the chronic cases. Inflammation, most likely secondary to medial necrosis, varied from predominantly neutrophilic infiltrates in the media and periadventitial tissue in the acute group to the presence of mainly hemosiderophages in the periadventitial tissue in the chronic group. Medial fibrosis with aberrant collagen morphology was seen in the subacute group and, more commonly, in the chronic group. Only minimal changes were seen in the aortic vasa vasorum. Smooth muscle hypertrophy and accumulation of mucoid material were not related to the age of the lesions. The findings of this study suggest that a connective tissue disorder affecting elastin or collagen in the aortic media is potentially the underlying cause of aortic rupture in Friesian horses.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
aorta, Friesian horses, histology, immunohistochemistry, laminar medial necrosis, aortopulmonary fistulation, pseudoaneurysm, vasa vasorum, CYSTIC MEDIAL NECROSIS, SMOOTH-MUSCLE-CELLS, ASCENDING AORTA, THOROUGHBRED MARES, MARFAN-SYNDROME, ANEURYSMS, MATRIX, ELASTIN, DISEASE, HYPERTENSION
journal title
VETERINARY PATHOLOGY
Vet. Pathol.
volume
52
issue
1
pages
152 - 159
Web of Science type
Article
Web of Science id
000347300600018
JCR category
VETERINARY SCIENCES
JCR impact factor
2.12 (2015)
JCR rank
13/138 (2015)
JCR quartile
1 (2015)
ISSN
0300-9858
DOI
10.1177/0300985814528219
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors are authors with equal contribution
copyright statement
I have transferred the copyright for this publication to the publisher
id
6862465
handle
http://hdl.handle.net/1854/LU-6862465
date created
2015-07-03 14:32:54
date last changed
2017-11-27 09:02:10
@article{6862465,
  abstract     = {Aortic rupture in horses is a rare condition. Although it is relatively common in the Friesian breed, only limited histopathologic information is available. Twenty Friesian horses (1-10 years old) were diagnosed with aortic rupture by postmortem examination. Ruptured aortic walls were analyzed with histology and immunohistochemistry. Based on the histologic and immunohistochemical findings, these cases were divided into 3 groups: acute (n = 4, 20\%), subacute (n = 8, 40\%), and chronic (n = 8, 40\%). Features common to samples from horses in all groups included accumulation of mucoid material; disorganization and fragmentation of the elastic laminae; aortic medial smooth muscle hypertrophy; and medial necrosis of varying degrees, ranging from mild and patchy in the acute cases to severe midzonal necrosis in the chronic cases. Inflammation, most likely secondary to medial necrosis, varied from predominantly neutrophilic infiltrates in the media and periadventitial tissue in the acute group to the presence of mainly hemosiderophages in the periadventitial tissue in the chronic group. Medial fibrosis with aberrant collagen morphology was seen in the subacute group and, more commonly, in the chronic group. Only minimal changes were seen in the aortic vasa vasorum. Smooth muscle hypertrophy and accumulation of mucoid material were not related to the age of the lesions. The findings of this study suggest that a connective tissue disorder affecting elastin or collagen in the aortic media is potentially the underlying cause of aortic rupture in Friesian horses.},
  author       = {Ploeg, Margreet and Saey, Veronique and Delesalle, Catherine and Gr{\"o}ne, A and Ducatelle, Richard and de Bruijn, Marco and Back, Willem and van Weeren, PR and van Loon, Gunther and Chiers, Koen},
  issn         = {0300-9858},
  journal      = {VETERINARY PATHOLOGY},
  keyword      = {aorta,Friesian horses,histology,immunohistochemistry,laminar medial necrosis,aortopulmonary fistulation,pseudoaneurysm,vasa vasorum,CYSTIC MEDIAL NECROSIS,SMOOTH-MUSCLE-CELLS,ASCENDING AORTA,THOROUGHBRED MARES,MARFAN-SYNDROME,ANEURYSMS,MATRIX,ELASTIN,DISEASE,HYPERTENSION},
  language     = {eng},
  number       = {1},
  pages        = {152--159},
  title        = {Thoracic aortic rupture and aortopulmonary fistulation in the Friesian horse : histomorphologic characterization},
  url          = {http://dx.doi.org/10.1177/0300985814528219},
  volume       = {52},
  year         = {2015},
}

Chicago
Ploeg, Margreet, Veronique Saey, Catherine Delesalle, A Gröne, Richard Ducatelle, Marco de Bruijn, Willem Back, PR van Weeren, Gunther van Loon, and Koen Chiers. 2015. “Thoracic Aortic Rupture and Aortopulmonary Fistulation in the Friesian Horse : Histomorphologic Characterization.” Veterinary Pathology 52 (1): 152–159.
APA
Ploeg, Margreet, Saey, V., Delesalle, C., Gröne, A., Ducatelle, R., de Bruijn, M., Back, W., et al. (2015). Thoracic aortic rupture and aortopulmonary fistulation in the Friesian horse : histomorphologic characterization. VETERINARY PATHOLOGY, 52(1), 152–159.
Vancouver
1.
Ploeg M, Saey V, Delesalle C, Gröne A, Ducatelle R, de Bruijn M, et al. Thoracic aortic rupture and aortopulmonary fistulation in the Friesian horse : histomorphologic characterization. VETERINARY PATHOLOGY. 2015;52(1):152–9.
MLA
Ploeg, Margreet, Veronique Saey, Catherine Delesalle, et al. “Thoracic Aortic Rupture and Aortopulmonary Fistulation in the Friesian Horse : Histomorphologic Characterization.” VETERINARY PATHOLOGY 52.1 (2015): 152–159. Print.