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Factors influencing adherence in cancer patients taking oral tyrosine kinase inhibitors : a qualitative study

(2016) CANCER NURSING. 39(2). p.153-162
Author
Organization
Abstract
Background: Nonadherence in cancer patients taking oral anticancer drugs is common. Reasons for nonadherence are still not really understood as influencing factors are often complex, dynamic, and interrelated. Objective: A qualitative study was conducted to gain insight into (non-)adherence behavior in patients taking oral tyrosine kinase inhibitors by exploring (1) processes and factors influencing (non-)adherence and (2) their interrelatedness. Methods: Semistructured interviews were held with 30 patients of different ages and with different types of cancer. A grounded theory approach was used. Results: Three foci were found when dealing with oral tyrosine kinase inhibitors: (1) a focus on survival, (2) a focus on quality of life, and (3) a balance between survival and quality of life. The process of adherence was determined by a set of complex and interrelated influencing factors: treatment-related side effects, hope, anxiety, trust, and feedback mechanisms. Conclusions: This qualitative study gives insight into processes and factors influencing (non-)adherence behavior in patients taking oral tyrosine kinase inhibitors. The results of this study can help healthcare professionals understand why patients taking oral tyrosine kinase inhibitors do not always adhere to their therapy. Implications for Practice: Conditions should be created by which patients get maximum opportunity to establish a balance between survival and quality of life. An open climate and a trust-based relationship should be established in which patients feel comfortable to openly discuss their therapy and the difficulties they experience.
Keywords
ANTICANCER DRUGS, WOMEN, NONADHERENCE, MEDICATION ADHERENCE, HORMONAL-THERAPY, IMATINIB THERAPY, OF-LIFE, BREAST-CANCER, CHRONIC MYELOID-LEUKEMIA, Adherence, Quality of Life, Qualitative Research, Oral Tyrosine Kinase Inhibitors, Oral Anticancer Drugs, Nursing, TKI, EGO DEPLETION

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MLA
Verbrugghe, Mathieu et al. “Factors Influencing Adherence in Cancer Patients Taking Oral Tyrosine Kinase Inhibitors : a Qualitative Study.” CANCER NURSING 39.2 (2016): 153–162. Print.
APA
Verbrugghe, M., Duprez, V., Beeckman, D., Grypdonck, M., Quaghebeur, M., Verschueren, C., Verhaeghe, S., et al. (2016). Factors influencing adherence in cancer patients taking oral tyrosine kinase inhibitors : a qualitative study. CANCER NURSING, 39(2), 153–162.
Chicago author-date
Verbrugghe, Mathieu, Veerle Duprez, Dimitri Beeckman, Maria Grypdonck, Marijke Quaghebeur, Caroline Verschueren, Sofie Verhaeghe, and Ann Van Hecke. 2016. “Factors Influencing Adherence in Cancer Patients Taking Oral Tyrosine Kinase Inhibitors : a Qualitative Study.” Cancer Nursing 39 (2): 153–162.
Chicago author-date (all authors)
Verbrugghe, Mathieu, Veerle Duprez, Dimitri Beeckman, Maria Grypdonck, Marijke Quaghebeur, Caroline Verschueren, Sofie Verhaeghe, and Ann Van Hecke. 2016. “Factors Influencing Adherence in Cancer Patients Taking Oral Tyrosine Kinase Inhibitors : a Qualitative Study.” Cancer Nursing 39 (2): 153–162.
Vancouver
1.
Verbrugghe M, Duprez V, Beeckman D, Grypdonck M, Quaghebeur M, Verschueren C, et al. Factors influencing adherence in cancer patients taking oral tyrosine kinase inhibitors : a qualitative study. CANCER NURSING. 2016;39(2):153–62.
IEEE
[1]
M. Verbrugghe et al., “Factors influencing adherence in cancer patients taking oral tyrosine kinase inhibitors : a qualitative study,” CANCER NURSING, vol. 39, no. 2, pp. 153–162, 2016.
@article{6862001,
  abstract     = {Background: Nonadherence in cancer patients taking oral anticancer drugs is common. Reasons for nonadherence are still not really understood as influencing factors are often complex, dynamic, and interrelated.
Objective: A qualitative study was conducted to gain insight into (non-)adherence behavior in patients taking oral tyrosine kinase inhibitors by exploring (1) processes and factors influencing (non-)adherence and (2) their interrelatedness.
Methods: Semistructured interviews were held with 30 patients of different ages and with different types of cancer. A grounded theory approach was used.
Results: Three foci were found when dealing with oral tyrosine kinase inhibitors: (1) a focus on survival, (2) a focus on quality of life, and (3) a balance between survival and quality of life. The process of adherence was determined by a set of complex and interrelated influencing factors: treatment-related side effects, hope, anxiety, trust, and feedback mechanisms.
Conclusions: This qualitative study gives insight into processes and factors influencing (non-)adherence behavior in patients taking oral tyrosine kinase inhibitors. The results of this study can help healthcare professionals understand why patients taking oral tyrosine kinase inhibitors do not always adhere to their therapy.
Implications for Practice: Conditions should be created by which patients get maximum opportunity to establish a balance between survival and quality of life. An open climate and a trust-based relationship should be established in which patients feel comfortable to openly discuss their therapy and the difficulties they experience.},
  author       = {Verbrugghe, Mathieu and Duprez, Veerle and Beeckman, Dimitri and Grypdonck, Maria and Quaghebeur, Marijke and Verschueren, Caroline and Verhaeghe, Sofie and Van Hecke, Ann},
  issn         = {0162-220X},
  journal      = {CANCER NURSING},
  keywords     = {ANTICANCER DRUGS,WOMEN,NONADHERENCE,MEDICATION ADHERENCE,HORMONAL-THERAPY,IMATINIB THERAPY,OF-LIFE,BREAST-CANCER,CHRONIC MYELOID-LEUKEMIA,Adherence,Quality of Life,Qualitative Research,Oral Tyrosine Kinase Inhibitors,Oral Anticancer Drugs,Nursing,TKI,EGO DEPLETION},
  language     = {eng},
  number       = {2},
  pages        = {153--162},
  title        = {Factors influencing adherence in cancer patients taking oral tyrosine kinase inhibitors : a qualitative study},
  url          = {http://dx.doi.org/10.1097/NCC.0000000000000250},
  volume       = {39},
  year         = {2016},
}

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