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Concise review: Macrophages: versatile gatekeepers during pancreatic β-cell development, injury, and regeneration

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Abstract
Macrophages are classically considered detrimental for pancreatic beta-cell survival and function, thereby contributing to beta-cell failure in both type 1 (T1D) and 2 (T2D) diabetes mellitus. In addition, adipose tissue macrophages negatively influence peripheral insulin signaling and promote obesity-induced insulin resistance in T2D. In contrast, recent data unexpectedly uncovered that macrophages are not only able to protect beta cells during pancreatitis but also to orchestrate beta-cell proliferation and regeneration after beta-cell injury. Moreover, by altering their activation state, macrophages are able to improve insulin resistance in murine models of T2D. This review will elaborate on current insights in macrophage heterogeneity and on the evolving role of pancreas macrophages during organogenesis, tissue injury, and repair. Additional identification of macrophage subtypes and of their secreted factors might ultimately translate into novel therapeutic strategies for both T1D and T2D.
Keywords
GLUCOSE-HOMEOSTASIS, IN-VITRO, GENE-EXPRESSION, DENDRITIC CELLS, BLOOD-VESSELS, Pancreas, beta Cell, Development, Injury, Regeneration, Macrophage, ADIPOSE-TISSUE MACROPHAGES, ALTERNATIVELY ACTIVATED MACROPHAGES, MYELOID CELLS, INSULIN-RESISTANCE, ISLET INFLAMMATION

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Citation

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Chicago
Van Gassen, Naomi, Willem Staels, Eva Van Overmeire, Sofie De Groef, Mozhdeh Sojoodi, Yves Heremans, Gunter Leuckx, et al. 2015. “Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic Β-cell Development, Injury, and Regeneration.” Stem Cells Translational Medicine 4 (6): 555–563.
APA
Van Gassen, N., Staels, W., Van Overmeire, E., De Groef, S., Sojoodi, M., Heremans, Y., Leuckx, G., et al. (2015). Concise review: Macrophages: versatile gatekeepers during pancreatic β-cell development, injury, and regeneration. STEM CELLS TRANSLATIONAL MEDICINE, 4(6), 555–563.
Vancouver
1.
Van Gassen N, Staels W, Van Overmeire E, De Groef S, Sojoodi M, Heremans Y, et al. Concise review: Macrophages: versatile gatekeepers during pancreatic β-cell development, injury, and regeneration. STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(6):555–63.
MLA
Van Gassen, Naomi, Willem Staels, Eva Van Overmeire, et al. “Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic Β-cell Development, Injury, and Regeneration.” STEM CELLS TRANSLATIONAL MEDICINE 4.6 (2015): 555–563. Print.
@article{6854233,
  abstract     = {Macrophages are classically considered detrimental for pancreatic beta-cell survival and function, thereby contributing to beta-cell failure in both type 1 (T1D) and 2 (T2D) diabetes mellitus. In addition, adipose tissue macrophages negatively influence peripheral insulin signaling and promote obesity-induced insulin resistance in T2D. In contrast, recent data unexpectedly uncovered that macrophages are not only able to protect beta cells during pancreatitis but also to orchestrate beta-cell proliferation and regeneration after beta-cell injury. Moreover, by altering their activation state, macrophages are able to improve insulin resistance in murine models of T2D. This review will elaborate on current insights in macrophage heterogeneity and on the evolving role of pancreas macrophages during organogenesis, tissue injury, and repair. Additional identification of macrophage subtypes and of their secreted factors might ultimately translate into novel therapeutic strategies for both T1D and T2D.},
  author       = {Van Gassen, Naomi and Staels, Willem and Van Overmeire, Eva and De Groef, Sofie and Sojoodi, Mozhdeh and Heremans, Yves and Leuckx, Gunter and Van de Casteele, Mark and Van Ginderachter, Jo A and Heimberg, Harry and De Leu, Nico},
  issn         = {2157-6564},
  journal      = {STEM CELLS TRANSLATIONAL MEDICINE},
  keyword      = {GLUCOSE-HOMEOSTASIS,IN-VITRO,GENE-EXPRESSION,DENDRITIC CELLS,BLOOD-VESSELS,Pancreas,beta Cell,Development,Injury,Regeneration,Macrophage,ADIPOSE-TISSUE MACROPHAGES,ALTERNATIVELY ACTIVATED MACROPHAGES,MYELOID CELLS,INSULIN-RESISTANCE,ISLET INFLAMMATION},
  language     = {eng},
  number       = {6},
  pages        = {555--563},
  title        = {Concise review: Macrophages: versatile gatekeepers during pancreatic \ensuremath{\beta}-cell development, injury, and regeneration},
  url          = {http://dx.doi.org/10.5966/sctm.2014-0272},
  volume       = {4},
  year         = {2015},
}

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