Advanced search
Add to list

Breaking barriers : expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

Yves Briers (UGent) and Rob Lavigne
(2015) FUTURE MICROBIOLOGY. 10(3). p.377-390
Author
Organization
Abstract
The emergence and spread of antibiotic-resistant bacteria drives the search for novel classes of antibiotics to replenish our armamentarium against bacterial infections. This is particularly critical for Gram-negative pathogens, which are intrinsically resistant to many existing classes of antibiotics due to the presence of a protective outer membrane. In addition, the antibiotics development pipeline is mainly oriented to Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus. A promising novel class of antibacterials is endolysins. These enzymes encoded by bacterial viruses hydrolyze the peptidoglycan layer with high efficiency, resulting in abrupt osmotic lysis and cell death. Their potential as novel antibacterials to treat Gram-positive bacteria has been extensively demonstrated; however, the Gram-negative outer membrane has presented a formidable barrier for the use of endolysins against Gram-negatives until recently. This review reports on the most recent advances in the development of endolysins to kill Gram-negative species with a special focus on endolysin-engineered Artilysins (R).
Keywords
Art-175, antibiotic resistance, Artilysin (R), endolysin, Gram-negative, novel antibiotics, outer membrane, AMYLOLIQUEFACIENS PHAGE ENDOLYSIN, HIGH HYDROSTATIC-PRESSURE, OUTER-MEMBRANE PERMEABILITY, PSEUDOMONAS-AERUGINOSA, STREPTOCOCCUS-PNEUMONIAE, GENOME SEQUENCE, LYTIC ENZYMES, PHI-KZ, LYSOZYME, PESTICIN

Citation

Please use this url to cite or link to this publication:

MLA
Briers, Yves, and Rob Lavigne. “Breaking Barriers : Expansion of the Use of Endolysins as Novel Antibacterials Against Gram-negative Bacteria.” FUTURE MICROBIOLOGY 10.3 (2015): 377–390. Print.
APA
Briers, Y., & Lavigne, R. (2015). Breaking barriers : expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria. FUTURE MICROBIOLOGY, 10(3), 377–390.
Chicago author-date
Briers, Yves, and Rob Lavigne. 2015. “Breaking Barriers : Expansion of the Use of Endolysins as Novel Antibacterials Against Gram-negative Bacteria.” Future Microbiology 10 (3): 377–390.
Chicago author-date (all authors)
Briers, Yves, and Rob Lavigne. 2015. “Breaking Barriers : Expansion of the Use of Endolysins as Novel Antibacterials Against Gram-negative Bacteria.” Future Microbiology 10 (3): 377–390.
Vancouver
1.
Briers Y, Lavigne R. Breaking barriers : expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria. FUTURE MICROBIOLOGY. 2015;10(3):377–90.
IEEE
[1]
Y. Briers and R. Lavigne, “Breaking barriers : expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria,” FUTURE MICROBIOLOGY, vol. 10, no. 3, pp. 377–390, 2015.
@article{6846344,
  abstract     = {The emergence and spread of antibiotic-resistant bacteria drives the search for novel classes of antibiotics to replenish our armamentarium against bacterial infections. This is particularly critical for Gram-negative pathogens, which are intrinsically resistant to many existing classes of antibiotics due to the presence of a protective outer membrane. In addition, the antibiotics development pipeline is mainly oriented to Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus. A promising novel class of antibacterials is endolysins. These enzymes encoded by bacterial viruses hydrolyze the peptidoglycan layer with high efficiency, resulting in abrupt osmotic lysis and cell death. Their potential as novel antibacterials to treat Gram-positive bacteria has been extensively demonstrated; however, the Gram-negative outer membrane has presented a formidable barrier for the use of endolysins against Gram-negatives until recently. This review reports on the most recent advances in the development of endolysins to kill Gram-negative species with a special focus on endolysin-engineered Artilysins (R).},
  author       = {Briers, Yves and Lavigne, Rob},
  issn         = {1746-0913},
  journal      = {FUTURE MICROBIOLOGY},
  keywords     = {Art-175,antibiotic resistance,Artilysin (R),endolysin,Gram-negative,novel antibiotics,outer membrane,AMYLOLIQUEFACIENS PHAGE ENDOLYSIN,HIGH HYDROSTATIC-PRESSURE,OUTER-MEMBRANE PERMEABILITY,PSEUDOMONAS-AERUGINOSA,STREPTOCOCCUS-PNEUMONIAE,GENOME SEQUENCE,LYTIC ENZYMES,PHI-KZ,LYSOZYME,PESTICIN},
  language     = {eng},
  number       = {3},
  pages        = {377--390},
  title        = {Breaking barriers : expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria},
  url          = {http://dx.doi.org/10.2217/FMB.15.8},
  volume       = {10},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: