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Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRSV vaccines

Hans Nauwynck (UGent) , Hanne Van Gorp (UGent) , Merijn Vanhee (UGent) , Uladzimir Karniychuk (UGent) , Marc Geldhof (UGent) , Jun Cao (UGent) , Mieke Verbeeck (UGent) and Wander Van Breedam (UGent)
(2012) TRANSBOUNDARY AND EMERGING DISEASES. 59(suppl. 1). p.50-54
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Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important infectious pathogen in pigs worldwide nowadays. Due to its genetic drift and increasing power to escape from immunity, PRRSV becomes more and more difficult to control. Based on a better knowledge of PRRSV, its interaction with the host cell, the macrophage, its pathogenesis and the immunity against this virus, new vaccines can now be constructed. This research-based development of new generation vaccines will allow swine industry to face the devastating consequences of PRRSV infections in the future. The present review summarizes the present knowledge on the pathogenesis, the immune response and the research-based vaccine development.
Keywords
PRRSV, CORONAVIRUS, SUSCEPTIBILITY, SWINE, LUNGS, APOPTOSIS, REPLICATION, PIGS, ALVEOLAR MACROPHAGES, NEUTRALIZING ANTIBODIES, RESPIRATORY SYNDROME VIRUS, vaccine, pathogenesis, immune response

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Chicago
Nauwynck, Hans, Hanne Van Gorp, Merijn Vanhee, Uladzimir Karniychuk, Marc Geldhof, Jun Cao, Mieke Verbeeck, and Wander Van Breedam. 2012. “Micro-dissecting the Pathogenesis and Immune Response of PRRSV Infection Paves the Way for More Efficient PRRSV Vaccines.” Transboundary and Emerging Diseases 59 (suppl. 1): 50–54.
APA
Nauwynck, H., Van Gorp, H., Vanhee, M., Karniychuk, U., Geldhof, M., Cao, J., Verbeeck, M., et al. (2012). Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRSV vaccines. TRANSBOUNDARY AND EMERGING DISEASES, 59(suppl. 1), 50–54.
Vancouver
1.
Nauwynck H, Van Gorp H, Vanhee M, Karniychuk U, Geldhof M, Cao J, et al. Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRSV vaccines. TRANSBOUNDARY AND EMERGING DISEASES. 2012;59(suppl. 1):50–4.
MLA
Nauwynck, Hans, Hanne Van Gorp, Merijn Vanhee, et al. “Micro-dissecting the Pathogenesis and Immune Response of PRRSV Infection Paves the Way for More Efficient PRRSV Vaccines.” TRANSBOUNDARY AND EMERGING DISEASES 59.suppl. 1 (2012): 50–54. Print.
@article{6844745,
  abstract     = {Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important infectious pathogen in pigs worldwide nowadays. Due to its genetic drift and increasing power to escape from immunity, PRRSV becomes more and more difficult to control. Based on a better knowledge of PRRSV, its interaction with the host cell, the macrophage, its pathogenesis and the immunity against this virus, new vaccines can now be constructed. This research-based development of new generation vaccines will allow swine industry to face the devastating consequences of PRRSV infections in the future. The present review summarizes the present knowledge on the pathogenesis, the immune response and the research-based vaccine development.},
  author       = {Nauwynck, Hans and Van Gorp, Hanne and Vanhee, Merijn and Karniychuk, Uladzimir and Geldhof, Marc and Cao, Jun and Verbeeck, Mieke and Van Breedam, Wander},
  issn         = {1865-1674},
  journal      = {TRANSBOUNDARY AND EMERGING DISEASES},
  keyword      = {PRRSV,CORONAVIRUS,SUSCEPTIBILITY,SWINE,LUNGS,APOPTOSIS,REPLICATION,PIGS,ALVEOLAR MACROPHAGES,NEUTRALIZING ANTIBODIES,RESPIRATORY SYNDROME VIRUS,vaccine,pathogenesis,immune response},
  language     = {eng},
  number       = {suppl. 1},
  pages        = {50--54},
  title        = {Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRSV vaccines},
  url          = {http://dx.doi.org/10.1111/j.1865-1682.2011.01292.x},
  volume       = {59},
  year         = {2012},
}

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