Advanced search
1 file | 195.44 KB Add to list

Model-based optimization of the primary drying step during freeze-drying

Author
Organization
Abstract
Since large molecules are considered the key driver for growth of the pharmaceutical industry, the focus of the pharmaceutical industry is shifting from small molecules to biopharmaceuticals: around 50% of the approved biopharmaceuticals are freeze-dried products. Therefore, freeze-drying is an important technology to stabilise biopharmaceutical drug products which are unstable in an aqueous solution. However, the freeze-drying process is an energy and time-consuming process. The use of mechanistic modelling to gather process knowledge can assist in optimisation of the process parameters during the operation of the freeze-drying process. By applying a dynamic shelf temperature and chamber pressure, which are the only controllable process variables, the processing time can be decreased by a factor 2 to 3.
Keywords
Modelling, Dynamic Design Space, Optimization, Pharmaceuticals

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 195.44 KB

Citation

Please use this url to cite or link to this publication:

MLA
Mortier, Séverine et al. “Model-based Optimization of the Primary Drying Step During Freeze-drying.” Computer Aided Chemical Engineering. Ed. Krist V Gernaey, Jakob K Huusom, & Rafiqul Gani. Vol. 37. Amsterdam, The Netherlands: Elsevier, 2015. 2177–2182. Print.
APA
Mortier, S., Van Bockstal, P.-J., Nopens, I., Gernaey, K. V., & De Beer, T. (2015). Model-based optimization of the primary drying step during freeze-drying. In K. V. Gernaey, J. K. Huusom, & R. Gani (Eds.), Computer Aided Chemical Engineering (Vol. 37, pp. 2177–2182). Presented at the 12th International symposium on Process Systems Engineering (PSE) ; 25th European symposium on Computer Aided Process Engineering (ESCAPE), Amsterdam, The Netherlands: Elsevier.
Chicago author-date
Mortier, Séverine, Pieter-Jan Van Bockstal, Ingmar Nopens, Krist V Gernaey, and Thomas De Beer. 2015. “Model-based Optimization of the Primary Drying Step During Freeze-drying.” In Computer Aided Chemical Engineering, ed. Krist V Gernaey, Jakob K Huusom, and Rafiqul Gani, 37:2177–2182. Amsterdam, The Netherlands: Elsevier.
Chicago author-date (all authors)
Mortier, Séverine, Pieter-Jan Van Bockstal, Ingmar Nopens, Krist V Gernaey, and Thomas De Beer. 2015. “Model-based Optimization of the Primary Drying Step During Freeze-drying.” In Computer Aided Chemical Engineering, ed. Krist V Gernaey, Jakob K Huusom, and Rafiqul Gani, 37:2177–2182. Amsterdam, The Netherlands: Elsevier.
Vancouver
1.
Mortier S, Van Bockstal P-J, Nopens I, Gernaey KV, De Beer T. Model-based optimization of the primary drying step during freeze-drying. In: Gernaey KV, Huusom JK, Gani R, editors. Computer Aided Chemical Engineering. Amsterdam, The Netherlands: Elsevier; 2015. p. 2177–82.
IEEE
[1]
S. Mortier, P.-J. Van Bockstal, I. Nopens, K. V. Gernaey, and T. De Beer, “Model-based optimization of the primary drying step during freeze-drying,” in Computer Aided Chemical Engineering, Cophenhagen, Denmark, 2015, vol. 37, pp. 2177–2182.
@inproceedings{6830197,
  abstract     = {Since large molecules are considered the key driver for growth of the pharmaceutical industry, the focus of the pharmaceutical industry is shifting from small molecules to biopharmaceuticals: around 50% of the approved biopharmaceuticals are freeze-dried products. Therefore, freeze-drying is an important technology to stabilise biopharmaceutical drug products which are unstable in an aqueous solution. However, the freeze-drying process is an energy and time-consuming process. The use of mechanistic modelling to gather process knowledge can assist in optimisation of the process parameters during the operation of the freeze-drying process. By applying a dynamic shelf temperature and chamber pressure, which are the only controllable process variables, the processing time can be decreased by a factor 2 to 3.},
  author       = {Mortier, Séverine and Van Bockstal, Pieter-Jan and Nopens, Ingmar and Gernaey, Krist V and De Beer, Thomas},
  booktitle    = {Computer Aided Chemical Engineering},
  editor       = {Gernaey, Krist V and Huusom, Jakob K and Gani, Rafiqul},
  isbn         = {9780444635761},
  issn         = {1570-7946},
  keywords     = {Modelling,Dynamic Design Space,Optimization,Pharmaceuticals},
  language     = {eng},
  location     = {Cophenhagen, Denmark},
  pages        = {2177--2182},
  publisher    = {Elsevier},
  title        = {Model-based optimization of the primary drying step during freeze-drying},
  volume       = {37},
  year         = {2015},
}

Web of Science
Times cited: