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The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment

Hannelore Denys (UGent) , Geert Braems (UGent) , Kathleen Lambein (UGent) , Patrick Pauwels (UGent) , An Hendrix (UGent) , Astrid De Boeck (UGent) , Veronique Mathieu, Marc Bracke (UGent) and Olivier De Wever (UGent)
(2009) CURRENT PHARMACEUTICAL DESIGN. 15(12). p.1373-1384
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Abstract
Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation of ECM at the invasion front. Therefore, we address the question whether the detection of ECM signatures in histopathology and biofluids may help predicting therapy resistance and determining the prognosis of cancer. Since the ECM is an attractive target for tumor therapy, current therapeutic strategies in preclinical or clinical development will be discussed.
Keywords
BETA(1) INTEGRIN, GENE-EXPRESSION, INDUCED APOPTOSIS, GROWTH-FACTOR, HUMAN BREAST-CANCER, PROSTATE-SPECIFIC ANTIGEN, MOLECULE HEPARANASE INHIBITORS, CELL LUNG-CANCER, RESISTANCE CAM-DR, FOCAL ADHESION KINASE

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Chicago
Denys, Hannelore, Geert Braems, Kathleen Lambein, Patrick Pauwels, An Hendrix, Astrid De Boeck, Veronique Mathieu, Marc Bracke, and Olivier De Wever. 2009. “The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment.” Current Pharmaceutical Design 15 (12): 1373–1384.
APA
Denys, H., Braems, G., Lambein, K., Pauwels, P., Hendrix, A., De Boeck, A., Mathieu, V., et al. (2009). The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment. CURRENT PHARMACEUTICAL DESIGN, 15(12), 1373–1384.
Vancouver
1.
Denys H, Braems G, Lambein K, Pauwels P, Hendrix A, De Boeck A, et al. The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment. CURRENT PHARMACEUTICAL DESIGN. 2009;15(12):1373–84.
MLA
Denys, Hannelore et al. “The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment.” CURRENT PHARMACEUTICAL DESIGN 15.12 (2009): 1373–1384. Print.
@article{678869,
  abstract     = {Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation of ECM at the invasion front. Therefore, we address the question whether the detection of ECM signatures in histopathology and biofluids may help predicting therapy resistance and determining the prognosis of cancer. Since the ECM is an attractive target for tumor therapy, current therapeutic strategies in preclinical or clinical development will be discussed.},
  author       = {Denys, Hannelore and Braems, Geert and Lambein, Kathleen and Pauwels, Patrick and Hendrix, An and De Boeck, Astrid and Mathieu, Veronique and Bracke, Marc and De Wever, Olivier},
  issn         = {1381-6128},
  journal      = {CURRENT PHARMACEUTICAL DESIGN},
  keywords     = {BETA(1) INTEGRIN,GENE-EXPRESSION,INDUCED APOPTOSIS,GROWTH-FACTOR,HUMAN BREAST-CANCER,PROSTATE-SPECIFIC ANTIGEN,MOLECULE HEPARANASE INHIBITORS,CELL LUNG-CANCER,RESISTANCE CAM-DR,FOCAL ADHESION KINASE},
  language     = {eng},
  number       = {12},
  pages        = {1373--1384},
  title        = {The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment},
  volume       = {15},
  year         = {2009},
}

Web of Science
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