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The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment

Hannelore Denys UGent, Geert Braems UGent, Kathleen Lambein UGent, Patrick Pauwels UGent, An Hendrix UGent, Astrid De Boeck UGent, Veronique Mathieu, Marc Bracke UGent and Olivier De Wever UGent (2009) CURRENT PHARMACEUTICAL DESIGN. 15(12). p.1373-1384
abstract
Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation of ECM at the invasion front. Therefore, we address the question whether the detection of ECM signatures in histopathology and biofluids may help predicting therapy resistance and determining the prognosis of cancer. Since the ECM is an attractive target for tumor therapy, current therapeutic strategies in preclinical or clinical development will be discussed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
BETA(1) INTEGRIN, GENE-EXPRESSION, INDUCED APOPTOSIS, GROWTH-FACTOR, HUMAN BREAST-CANCER, PROSTATE-SPECIFIC ANTIGEN, MOLECULE HEPARANASE INHIBITORS, CELL LUNG-CANCER, RESISTANCE CAM-DR, FOCAL ADHESION KINASE
journal title
CURRENT PHARMACEUTICAL DESIGN
Curr. Pharm. Design
volume
15
issue
12
pages
1373 - 1384
Web of Science type
Review
Web of Science id
000265789700009
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
4.414 (2009)
JCR rank
29/236 (2009)
JCR quartile
1 (2009)
ISSN
1381-6128
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
678869
handle
http://hdl.handle.net/1854/LU-678869
date created
2009-06-05 08:46:15
date last changed
2011-08-25 13:54:02
@article{678869,
  abstract     = {Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation of ECM at the invasion front. Therefore, we address the question whether the detection of ECM signatures in histopathology and biofluids may help predicting therapy resistance and determining the prognosis of cancer. Since the ECM is an attractive target for tumor therapy, current therapeutic strategies in preclinical or clinical development will be discussed.},
  author       = {Denys, Hannelore and Braems, Geert and Lambein, Kathleen and Pauwels, Patrick and Hendrix, An and De Boeck, Astrid and Mathieu, Veronique and Bracke, Marc and De Wever, Olivier},
  issn         = {1381-6128},
  journal      = {CURRENT PHARMACEUTICAL DESIGN},
  keyword      = {BETA(1) INTEGRIN,GENE-EXPRESSION,INDUCED APOPTOSIS,GROWTH-FACTOR,HUMAN BREAST-CANCER,PROSTATE-SPECIFIC ANTIGEN,MOLECULE HEPARANASE INHIBITORS,CELL LUNG-CANCER,RESISTANCE CAM-DR,FOCAL ADHESION KINASE},
  language     = {eng},
  number       = {12},
  pages        = {1373--1384},
  title        = {The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment},
  volume       = {15},
  year         = {2009},
}

Chicago
Denys, Hannelore, Geert Braems, Kathleen Lambein, Patrick Pauwels, An Hendrix, Astrid De Boeck, Veronique Mathieu, Marc Bracke, and Olivier De Wever. 2009. “The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment.” Current Pharmaceutical Design 15 (12): 1373–1384.
APA
Denys, H., Braems, G., Lambein, K., Pauwels, P., Hendrix, A., De Boeck, A., Mathieu, V., et al. (2009). The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment. CURRENT PHARMACEUTICAL DESIGN, 15(12), 1373–1384.
Vancouver
1.
Denys H, Braems G, Lambein K, Pauwels P, Hendrix A, De Boeck A, et al. The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment. CURRENT PHARMACEUTICAL DESIGN. 2009;15(12):1373–84.
MLA
Denys, Hannelore, Geert Braems, Kathleen Lambein, et al. “The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment.” CURRENT PHARMACEUTICAL DESIGN 15.12 (2009): 1373–1384. Print.