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Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

Karolien De Bosscher UGent and Guy Haegeman UGent (2009) MOLECULAR ENDOCRINOLOGY. 23(3). p.281-291
abstract
Taking into consideration that glucocorticoid ( GC) hormones have been used clinically for over half a century and that more than 20 yr have passed since the cloning of the GC receptor (GR), it is hard to imagine that novel aspects in the molecular mechanism by which GCs mediate their antiinflammatory actions are still being unveiled today. Partly, this is because almost on a daily basis, novel insights arise from parallel fields, e. g. nuclear receptor cofactor and chromatin regulation and their concomitant impact on gene transcription events, eventually leading to a revisitation or refinement of old hypotheses. On the other hand, it does remain striking and puzzling why GCs use different mechanisms in so many different cell types and on many different target genes to elicit an antiinflammatory effect. Meanwhile, the obvious question for the clinic remains: is the separation of GR functionalities through differential ligand design the strategy of choice to avoid most GC-mediated side effects? This minireview aims to highlight some of the latest findings on aspects of the antiinflammatory working mechanisms of GCs. ( Molecular Endocrinology 23: 281-291, 2009)
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
IN-VIVO, TRANSCRIPTIONAL ACTIVATION, MOLECULAR-MECHANISMS, C-JUN, DNA-BINDING, JUN GENE-EXPRESSION, INNATE IMMUNE-RESPONSES, PROTEIN-PROTEIN-INTERACTION, NF-KAPPA-B, INDUCED LEUCINE-ZIPPER
journal title
MOLECULAR ENDOCRINOLOGY
Mol. Endocrinol.
volume
23
issue
3
pages
281 - 291
publisher
ENDOCRINE SOC
place of publication
CHEVY CHASE, MD 20815-5817 USA
Web of Science type
Review
Web of Science id
000263668100001
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
5.257 (2009)
JCR rank
16/104 (2009)
JCR quartile
1 (2009)
ISSN
0888-8809
DOI
10.1210/me.2008-0283
language
English
UGent publication?
yes
classification
A1
additional info
IDS Number: 411RQ Reprint Address: De Bosscher, K (reprint author), Univ Ghent, Dept Physiol, LEGEST, KL Ledeganckstr 35, B-9000 Ghent, Belgium E-mail Addresses: Karolien.Debosscher@Ugent.be
id
676996
handle
http://hdl.handle.net/1854/LU-676996
date created
2009-06-04 08:53:50
date last changed
2009-06-04 12:12:40
@article{676996,
  abstract     = {Taking into consideration that glucocorticoid ( GC) hormones have been used clinically for over half a century and that more than 20 yr have passed since the cloning of the GC receptor (GR), it is hard to imagine that novel aspects in the molecular mechanism by which GCs mediate their antiinflammatory actions are still being unveiled today. Partly, this is because almost on a daily basis, novel insights arise from parallel fields, e. g. nuclear receptor cofactor and chromatin regulation and their concomitant impact on gene transcription events, eventually leading to a revisitation or refinement of old hypotheses. On the other hand, it does remain striking and puzzling why GCs use different mechanisms in so many different cell types and on many different target genes to elicit an antiinflammatory effect. Meanwhile, the obvious question for the clinic remains: is the separation of GR functionalities through differential ligand design the strategy of choice to avoid most GC-mediated side effects? This minireview aims to highlight some of the latest findings on aspects of the antiinflammatory working mechanisms of GCs. ( Molecular Endocrinology 23: 281-291, 2009)},
  author       = {De Bosscher, Karolien and Haegeman, Guy},
  issn         = {0888-8809},
  journal      = {MOLECULAR ENDOCRINOLOGY},
  keyword      = {IN-VIVO,TRANSCRIPTIONAL ACTIVATION,MOLECULAR-MECHANISMS,C-JUN,DNA-BINDING,JUN GENE-EXPRESSION,INNATE IMMUNE-RESPONSES,PROTEIN-PROTEIN-INTERACTION,NF-KAPPA-B,INDUCED LEUCINE-ZIPPER},
  language     = {eng},
  number       = {3},
  pages        = {281--291},
  publisher    = {ENDOCRINE SOC},
  title        = {Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids},
  url          = {http://dx.doi.org/10.1210/me.2008-0283},
  volume       = {23},
  year         = {2009},
}

Chicago
De Bosscher, Karolien, and Guy Haegeman. 2009. “Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids.” Molecular Endocrinology 23 (3): 281–291.
APA
De Bosscher, K., & Haegeman, G. (2009). Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids. MOLECULAR ENDOCRINOLOGY, 23(3), 281–291.
Vancouver
1.
De Bosscher K, Haegeman G. Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids. MOLECULAR ENDOCRINOLOGY. CHEVY CHASE, MD 20815-5817 USA: ENDOCRINE SOC; 2009;23(3):281–91.
MLA
De Bosscher, Karolien, and Guy Haegeman. “Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids.” MOLECULAR ENDOCRINOLOGY 23.3 (2009): 281–291. Print.