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Histologic and micro–computed tomographic evaluation of the osseointegration of a nonresorbable bone substitute in alveoli of ponies after tooth extraction

Lieven Vlaminck (UGent) , Veerle Cnudde (UGent) , Koen Pieters (UGent) , Wim Van Den Broeck (UGent) , Michel Steenhaut (UGent) , Patric Jacobs (UGent) and Frank Gasthuys (UGent)
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Abstract
Objective: To evaluate the biological behavior of a nonresorbable bone substitute (NRBS) in the alveoli of ponies, compared with tissue quality in naturally healing alveoli, after cheek tooth extraction. Animals: 5 clinically normal ponies. Procedures: In each pony, both maxillary fourth premolars (Triadan 108/208) were repulsed bilaterally during anesthesia. One randomly chosen alveolus was filled with NRBS and isolated from the oral cavity by use of dental impression material and a spring-wire retention device. The other alveolus was occluded in its occlusal third portion with dental impression material. One year after surgery, cylindrical lateromedial biopsy specimens were collected from the apical, middle, and occlusal level of each alveolus. Biopsy samples were evaluated for bone mineral density and bone volume via micro-computed tomography; qualitative histologic characteristics were evaluated via light microscopy. Results: Bone mineral density and bone volume were greater in control alveoli, compared with NRBS-treated alveoli. Control alveoli were characterized by the presence of few mature bone trabeculae and wide spaces containing fat tissue and mesenchymal stroma. In treated alveoli, biocompatibility and osteoconcluctive properties of the NRBS were excellent-, continuous bone formation and bone remodeling were also evident. Conclusions and Clinical Relevance: Results indicated that the NRBS was integrated well in calcified alveolar tissues in ponies 1 year after maxillary cheek tooth extraction. Further research is necessary to establish the benefits of this NRBS in the development of a dental implant surgical technique in equids.
Keywords
INTRAALVEOLAR PROSTHESIS, LONG-TERM, HTR POLYMER, CHEEK TEETH, HORSES, REPAIR, IMPLANT, GRAFT, COMPOSITE, SECTIONS

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Chicago
Vlaminck, Lieven, Veerle Cnudde, Koen Pieters, Wim Van Den Broeck, Michel Steenhaut, Patric Jacobs, and Frank Gasthuys. 2008. “Histologic and Micro–computed Tomographic Evaluation of the Osseointegration of a Nonresorbable Bone Substitute in Alveoli of Ponies After Tooth Extraction.” American Journal of Veterinary Research 69 (5): 604–610.
APA
Vlaminck, L., Cnudde, V., Pieters, K., Van Den Broeck, W., Steenhaut, M., Jacobs, P., & Gasthuys, F. (2008). Histologic and micro–computed tomographic evaluation of the osseointegration of a nonresorbable bone substitute in alveoli of ponies after tooth extraction. AMERICAN JOURNAL OF VETERINARY RESEARCH, 69(5), 604–610.
Vancouver
1.
Vlaminck L, Cnudde V, Pieters K, Van Den Broeck W, Steenhaut M, Jacobs P, et al. Histologic and micro–computed tomographic evaluation of the osseointegration of a nonresorbable bone substitute in alveoli of ponies after tooth extraction. AMERICAN JOURNAL OF VETERINARY RESEARCH. 2008;69(5):604–10.
MLA
Vlaminck, Lieven, Veerle Cnudde, Koen Pieters, et al. “Histologic and Micro–computed Tomographic Evaluation of the Osseointegration of a Nonresorbable Bone Substitute in Alveoli of Ponies After Tooth Extraction.” AMERICAN JOURNAL OF VETERINARY RESEARCH 69.5 (2008): 604–610. Print.
@article{676218,
  abstract     = {Objective: To evaluate the biological behavior of a nonresorbable bone substitute (NRBS) in the alveoli of ponies, compared with tissue quality in naturally healing alveoli, after cheek tooth extraction. 
Animals: 5 clinically normal ponies. 
Procedures: In each pony, both maxillary fourth premolars (Triadan 108/208) were repulsed bilaterally during anesthesia. One randomly chosen alveolus was filled with NRBS and isolated from the oral cavity by use of dental impression material and a spring-wire retention device. The other alveolus was occluded in its occlusal third portion with dental impression material. One year after surgery, cylindrical lateromedial biopsy specimens were collected from the apical, middle, and occlusal level of each alveolus. Biopsy samples were evaluated for bone mineral density and bone volume via micro-computed tomography; qualitative histologic characteristics were evaluated via light microscopy. 
Results: Bone mineral density and bone volume were greater in control alveoli, compared with NRBS-treated alveoli. Control alveoli were characterized by the presence of few mature bone trabeculae and wide spaces containing fat tissue and mesenchymal stroma. In treated alveoli, biocompatibility and osteoconcluctive properties of the NRBS were excellent-, continuous bone formation and bone remodeling were also evident.
Conclusions and Clinical Relevance: Results indicated that the NRBS was integrated well in calcified alveolar tissues in ponies 1 year after maxillary cheek tooth extraction. Further research is necessary to establish the benefits of this NRBS in the development of a dental implant surgical technique in equids.},
  author       = {Vlaminck, Lieven and Cnudde, Veerle and Pieters, Koen and Van Den Broeck, Wim and Steenhaut, Michel and Jacobs, Patric and Gasthuys, Frank},
  issn         = {0002-9645},
  journal      = {AMERICAN JOURNAL OF VETERINARY RESEARCH},
  keyword      = {INTRAALVEOLAR PROSTHESIS,LONG-TERM,HTR POLYMER,CHEEK TEETH,HORSES,REPAIR,IMPLANT,GRAFT,COMPOSITE,SECTIONS},
  language     = {eng},
  number       = {5},
  pages        = {604--610},
  title        = {Histologic and micro--computed tomographic evaluation of the osseointegration of a nonresorbable bone substitute in alveoli of ponies after tooth extraction},
  url          = {http://dx.doi.org/10.2460/ajvr.69.5.604},
  volume       = {69},
  year         = {2008},
}

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