Advanced search
1 file | 258.69 KB

Copy number alterations and copy number variation in cancer: close encounters of the bad kind

Franki Speleman (UGent) , Candy Kumps (UGent) , Karen Buysse (UGent) , Bruce Poppe (UGent) , Björn Menten (UGent) and Katleen De Preter (UGent)
(2008) CYTOGENETIC AND GENOME RESEARCH. 123(1-4). p.176-182
Author
Organization
Abstract
Recent studies have unveiled copy number variants (CNVs) as an important source of genetic variation. Many of these CNVs contain coding sequences, which have been shown to be dosage sensitive. Evidence is accumulating that certain CNVs have impact on susceptibility to human diseases such as HIV infection and autoimmune diseases, as well as on adaptability to environmental conditions or nutrition. The possible role and impact of CNVs on cancer development and progression is only now emerging. In this review we look into the role of CNVs and their associated genomic structural features in relation to the formation of chromosome alterations in cancer cells and evolutionary genomic plasticity, as well as the de novo occurrence of known or putative CNVs as somatic events during oncogenesis. The role of germline CNVs in cancer predisposition is still largely unexplored. A number of observations seem to warrant the importance of further studies to elucidate the impact of these variants in the early steps of carcinogenesis.
Keywords
MOLECULAR-BIOLOGY, ACUTE LYMPHOBLASTIC-LEUKEMIA, COMPARATIVE GENOMIC HYBRIDIZATION, GENE, BREAKPOINTS, SEGMENTAL DUPLICATIONS, STRUCTURAL VARIATION, CHROMOSOMAL REARRANGEMENTS, TRANSLOCATION, NEUROBLASTOMA

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 258.69 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Speleman, Franki, Candy Kumps, Karen Buysse, Bruce Poppe, Björn Menten, and Katleen De Preter. 2008. “Copy Number Alterations and Copy Number Variation in Cancer: Close Encounters of the Bad Kind.” Cytogenetic and Genome Research 123 (1-4): 176–182.
APA
Speleman, F., Kumps, C., Buysse, K., Poppe, B., Menten, B., & De Preter, K. (2008). Copy number alterations and copy number variation in cancer: close encounters of the bad kind. CYTOGENETIC AND GENOME RESEARCH, 123(1-4), 176–182.
Vancouver
1.
Speleman F, Kumps C, Buysse K, Poppe B, Menten B, De Preter K. Copy number alterations and copy number variation in cancer: close encounters of the bad kind. CYTOGENETIC AND GENOME RESEARCH. 2008;123(1-4):176–82.
MLA
Speleman, Franki et al. “Copy Number Alterations and Copy Number Variation in Cancer: Close Encounters of the Bad Kind.” CYTOGENETIC AND GENOME RESEARCH 123.1-4 (2008): 176–182. Print.
@article{674925,
  abstract     = {Recent studies have unveiled copy number variants (CNVs) as an important source of genetic variation. Many of these CNVs contain coding sequences, which have been shown to be dosage sensitive. Evidence is accumulating that certain CNVs have impact on susceptibility to human diseases such as HIV infection and autoimmune diseases, as well as on adaptability to environmental conditions or nutrition. The possible role and impact of CNVs on cancer development and progression is only now emerging. In this review we look into the role of CNVs and their associated genomic structural features in relation to the formation of chromosome alterations in cancer cells and evolutionary genomic plasticity, as well as the de novo occurrence of known or putative CNVs as somatic events during oncogenesis. The role of germline CNVs in cancer predisposition is still largely unexplored. A number of observations seem to warrant the importance of further studies to elucidate the impact of these variants in the early steps of carcinogenesis.},
  author       = {Speleman, Franki and Kumps, Candy and Buysse, Karen and Poppe, Bruce and Menten, Björn and De Preter, Katleen},
  issn         = {1424-8581},
  journal      = {CYTOGENETIC AND GENOME RESEARCH},
  keywords     = {MOLECULAR-BIOLOGY,ACUTE LYMPHOBLASTIC-LEUKEMIA,COMPARATIVE GENOMIC HYBRIDIZATION,GENE,BREAKPOINTS,SEGMENTAL DUPLICATIONS,STRUCTURAL VARIATION,CHROMOSOMAL REARRANGEMENTS,TRANSLOCATION,NEUROBLASTOMA},
  language     = {eng},
  number       = {1-4},
  pages        = {176--182},
  title        = {Copy number alterations and copy number variation in cancer: close encounters of the bad kind},
  url          = {http://dx.doi.org/10.1159/000184706},
  volume       = {123},
  year         = {2008},
}

Altmetric
View in Altmetric
Web of Science
Times cited: