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Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets

Stijn Schauvliege UGent, STEFAAN BOUCHEZ UGent, Lindsey Devisscher UGent, Tim Reyns, Sandra De Boever UGent and Frank Gasthuys UGent (2009) VETERINARY ANAESTHESIA AND ANALGESIA. 36(3). p.230-238
abstract
Objective To investigate the influence of two ventilation modes on the performance of an anaesthetic conserving device (AnaConDa) in piglets. Study design Prospective randomized experimental trial. Animals Eight female piglets weighing 24.7 +/- 2.2 kg. Methods Anaesthesia was maintained with sevoflurane (in 60% oxygen) delivered from the AnaConDa placed between endotracheal tube (ETT) and Y-piece. Anaesthetic depth was guided using standard clinical parameters. Ventilation mode was volume controlled (VC) during the first and pressure support (PS) during the second period of anaesthesia in four piglets (group 1); the order was reversed in group 2. Anaesthetic gases were sampled before (at the proximal end of the ETT) and after the AnaConDa (Y-piece). Data were analysed using a model I ANOVA, with treatment and group as fixed categorical effects. Using a paired t-test, partial pressures of carbon dioxide (PE'CO2) on both sides of the device were compared. Results Although the mean administration rate of sevoflurane was comparable in both groups (3.8 +/- 1.8 mL hour(-1)), E'Sevo was higher in group 1, more specifically during the first period (p = 0.035). Less sevoflurane escaped during VC (14.0 +/- 3.4%) compared with PS ventilation (17.2 +/- 5.7%) (p = 0.001). PE'CO2 was lower at the Y-piece (6.4 +/- 0.8 kPa, 48 +/- 6 mmHg) compared with the ETT (9.3 +/- 1.4 kPa, 70 +/- 11 mmHg) in both groups and ventilation modes. On average, inspiratory CO2 tension was 2.0 +/- 1.0 kPa (15 +/- 8 mmHg). Respiration rate was comparable in all piglets while tidal volume (V-T) and peak inspiratory pressure were lower during VC compared with PS (p < 0.001, p = 0.015 respectively). Conclusions and clinical relevance The observed differences in E'Sevo concentration and sevoflurane breakthrough were probably related to differences in V-T. The observed high FICO2 indicated an excessive dead space with the AnaConDa for these piglets.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
REFLECTION FILTER, CIRCLE SYSTEM, PROPOFOL-INFUSION SYNDROME, volume controlled ventilation, sevoflurane, pressure support ventilation, anaesthetic conserving device, piglets, ISOFLURANE, SEDATION, FLOW, ANACONDA(R), VAPORS
journal title
VETERINARY ANAESTHESIA AND ANALGESIA
Vet. Anaesth. Analg.
volume
36
issue
3
pages
230 - 238
Web of Science type
Article
Web of Science id
000264963900004
JCR category
VETERINARY SCIENCES
JCR impact factor
1.426 (2009)
JCR rank
35/141 (2009)
JCR quartile
1 (2009)
ISSN
1467-2987
DOI
10.1111/j.1467-2995.2009.00453.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
671679
handle
http://hdl.handle.net/1854/LU-671679
date created
2009-05-29 11:16:10
date last changed
2010-09-07 17:00:35
@article{671679,
  abstract     = {Objective To investigate the influence of two ventilation modes on the performance of an anaesthetic conserving device (AnaConDa) in piglets.
Study design Prospective randomized experimental trial.
Animals Eight female piglets weighing 24.7 +/- 2.2 kg.
Methods Anaesthesia was maintained with sevoflurane (in 60\% oxygen) delivered from the AnaConDa placed between endotracheal tube (ETT) and Y-piece. Anaesthetic depth was guided using standard clinical parameters. Ventilation mode was volume controlled (VC) during the first and pressure support (PS) during the second period of anaesthesia in four piglets (group 1); the order was reversed in group 2. Anaesthetic gases were sampled before (at the proximal end of the ETT) and after the AnaConDa (Y-piece). Data were analysed using a model I ANOVA, with treatment and group as fixed categorical effects. Using a paired t-test, partial pressures of carbon dioxide (PE'CO2) on both sides of the device were compared.
Results Although the mean administration rate of sevoflurane was comparable in both groups (3.8 +/- 1.8 mL hour(-1)), E'Sevo was higher in group 1, more specifically during the first period (p = 0.035). Less sevoflurane escaped during VC (14.0 +/- 3.4\%) compared with PS ventilation (17.2 +/- 5.7\%) (p = 0.001). PE'CO2 was lower at the Y-piece (6.4 +/- 0.8 kPa, 48 +/- 6 mmHg) compared with the ETT (9.3 +/- 1.4 kPa, 70 +/- 11 mmHg) in both groups and ventilation modes. On average, inspiratory CO2 tension was 2.0 +/- 1.0 kPa (15 +/- 8 mmHg). Respiration rate was comparable in all piglets while tidal volume (V-T) and peak inspiratory pressure were lower during VC compared with PS (p {\textlangle} 0.001, p = 0.015 respectively).
Conclusions and clinical relevance The observed differences in E'Sevo concentration and sevoflurane breakthrough were probably related to differences in V-T. The observed high FICO2 indicated an excessive dead space with the AnaConDa for these piglets.},
  author       = {Schauvliege, Stijn and BOUCHEZ, STEFAAN and Devisscher, Lindsey and Reyns, Tim and De Boever, Sandra and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keyword      = {REFLECTION FILTER,CIRCLE SYSTEM,PROPOFOL-INFUSION SYNDROME,volume controlled ventilation,sevoflurane,pressure support ventilation,anaesthetic conserving device,piglets,ISOFLURANE,SEDATION,FLOW,ANACONDA(R),VAPORS},
  language     = {eng},
  number       = {3},
  pages        = {230--238},
  title        = {Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2009.00453.x},
  volume       = {36},
  year         = {2009},
}

Chicago
Schauvliege, Stijn, STEFAAN BOUCHEZ, Lindsey Devisscher, Tim Reyns, Sandra De Boever, and Frank Gasthuys. 2009. “Influence of Two Different Ventilation Modes on the Function of an Anaesthetic Conserving Device in Sevoflurane Anaesthetized Piglets.” Veterinary Anaesthesia and Analgesia 36 (3): 230–238.
APA
Schauvliege, S., BOUCHEZ, S., Devisscher, L., Reyns, T., De Boever, S., & Gasthuys, F. (2009). Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets. VETERINARY ANAESTHESIA AND ANALGESIA, 36(3), 230–238.
Vancouver
1.
Schauvliege S, BOUCHEZ S, Devisscher L, Reyns T, De Boever S, Gasthuys F. Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets. VETERINARY ANAESTHESIA AND ANALGESIA. 2009;36(3):230–8.
MLA
Schauvliege, Stijn, STEFAAN BOUCHEZ, Lindsey Devisscher, et al. “Influence of Two Different Ventilation Modes on the Function of an Anaesthetic Conserving Device in Sevoflurane Anaesthetized Piglets.” VETERINARY ANAESTHESIA AND ANALGESIA 36.3 (2009): 230–238. Print.