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Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets

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Abstract
Objective To investigate the influence of two ventilation modes on the performance of an anaesthetic conserving device (AnaConDa) in piglets. Study design Prospective randomized experimental trial. Animals Eight female piglets weighing 24.7 +/- 2.2 kg. Methods Anaesthesia was maintained with sevoflurane (in 60% oxygen) delivered from the AnaConDa placed between endotracheal tube (ETT) and Y-piece. Anaesthetic depth was guided using standard clinical parameters. Ventilation mode was volume controlled (VC) during the first and pressure support (PS) during the second period of anaesthesia in four piglets (group 1); the order was reversed in group 2. Anaesthetic gases were sampled before (at the proximal end of the ETT) and after the AnaConDa (Y-piece). Data were analysed using a model I ANOVA, with treatment and group as fixed categorical effects. Using a paired t-test, partial pressures of carbon dioxide (PE'CO2) on both sides of the device were compared. Results Although the mean administration rate of sevoflurane was comparable in both groups (3.8 +/- 1.8 mL hour(-1)), E'Sevo was higher in group 1, more specifically during the first period (p = 0.035). Less sevoflurane escaped during VC (14.0 +/- 3.4%) compared with PS ventilation (17.2 +/- 5.7%) (p = 0.001). PE'CO2 was lower at the Y-piece (6.4 +/- 0.8 kPa, 48 +/- 6 mmHg) compared with the ETT (9.3 +/- 1.4 kPa, 70 +/- 11 mmHg) in both groups and ventilation modes. On average, inspiratory CO2 tension was 2.0 +/- 1.0 kPa (15 +/- 8 mmHg). Respiration rate was comparable in all piglets while tidal volume (V-T) and peak inspiratory pressure were lower during VC compared with PS (p < 0.001, p = 0.015 respectively). Conclusions and clinical relevance The observed differences in E'Sevo concentration and sevoflurane breakthrough were probably related to differences in V-T. The observed high FICO2 indicated an excessive dead space with the AnaConDa for these piglets.
Keywords
REFLECTION FILTER, CIRCLE SYSTEM, PROPOFOL-INFUSION SYNDROME, volume controlled ventilation, sevoflurane, pressure support ventilation, anaesthetic conserving device, piglets, ISOFLURANE, SEDATION, FLOW, ANACONDA(R), VAPORS

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MLA
Schauvliege, Stijn et al. “Influence of Two Different Ventilation Modes on the Function of an Anaesthetic Conserving Device in Sevoflurane Anaesthetized Piglets.” VETERINARY ANAESTHESIA AND ANALGESIA 36.3 (2009): 230–238. Print.
APA
Schauvliege, S., Bouchez, S., Devisscher, L., Reyns, T., De Boever, S., & Gasthuys, F. (2009). Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets. VETERINARY ANAESTHESIA AND ANALGESIA, 36(3), 230–238.
Chicago author-date
Schauvliege, Stijn, Stefaan Bouchez, Lindsey Devisscher, Tim Reyns, Sandra De Boever, and Frank Gasthuys. 2009. “Influence of Two Different Ventilation Modes on the Function of an Anaesthetic Conserving Device in Sevoflurane Anaesthetized Piglets.” Veterinary Anaesthesia and Analgesia 36 (3): 230–238.
Chicago author-date (all authors)
Schauvliege, Stijn, Stefaan Bouchez, Lindsey Devisscher, Tim Reyns, Sandra De Boever, and Frank Gasthuys. 2009. “Influence of Two Different Ventilation Modes on the Function of an Anaesthetic Conserving Device in Sevoflurane Anaesthetized Piglets.” Veterinary Anaesthesia and Analgesia 36 (3): 230–238.
Vancouver
1.
Schauvliege S, Bouchez S, Devisscher L, Reyns T, De Boever S, Gasthuys F. Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets. VETERINARY ANAESTHESIA AND ANALGESIA. 2009;36(3):230–8.
IEEE
[1]
S. Schauvliege, S. Bouchez, L. Devisscher, T. Reyns, S. De Boever, and F. Gasthuys, “Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets,” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 36, no. 3, pp. 230–238, 2009.
@article{671679,
  abstract     = {Objective To investigate the influence of two ventilation modes on the performance of an anaesthetic conserving device (AnaConDa) in piglets.
Study design Prospective randomized experimental trial.
Animals Eight female piglets weighing 24.7 +/- 2.2 kg.
Methods Anaesthesia was maintained with sevoflurane (in 60% oxygen) delivered from the AnaConDa placed between endotracheal tube (ETT) and Y-piece. Anaesthetic depth was guided using standard clinical parameters. Ventilation mode was volume controlled (VC) during the first and pressure support (PS) during the second period of anaesthesia in four piglets (group 1); the order was reversed in group 2. Anaesthetic gases were sampled before (at the proximal end of the ETT) and after the AnaConDa (Y-piece). Data were analysed using a model I ANOVA, with treatment and group as fixed categorical effects. Using a paired t-test, partial pressures of carbon dioxide (PE'CO2) on both sides of the device were compared.
Results Although the mean administration rate of sevoflurane was comparable in both groups (3.8 +/- 1.8 mL hour(-1)), E'Sevo was higher in group 1, more specifically during the first period (p = 0.035). Less sevoflurane escaped during VC (14.0 +/- 3.4%) compared with PS ventilation (17.2 +/- 5.7%) (p = 0.001). PE'CO2 was lower at the Y-piece (6.4 +/- 0.8 kPa, 48 +/- 6 mmHg) compared with the ETT (9.3 +/- 1.4 kPa, 70 +/- 11 mmHg) in both groups and ventilation modes. On average, inspiratory CO2 tension was 2.0 +/- 1.0 kPa (15 +/- 8 mmHg). Respiration rate was comparable in all piglets while tidal volume (V-T) and peak inspiratory pressure were lower during VC compared with PS (p < 0.001, p = 0.015 respectively).
Conclusions and clinical relevance The observed differences in E'Sevo concentration and sevoflurane breakthrough were probably related to differences in V-T. The observed high FICO2 indicated an excessive dead space with the AnaConDa for these piglets.},
  author       = {Schauvliege, Stijn and Bouchez, Stefaan and Devisscher, Lindsey and Reyns, Tim and De Boever, Sandra and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keywords     = {REFLECTION FILTER,CIRCLE SYSTEM,PROPOFOL-INFUSION SYNDROME,volume controlled ventilation,sevoflurane,pressure support ventilation,anaesthetic conserving device,piglets,ISOFLURANE,SEDATION,FLOW,ANACONDA(R),VAPORS},
  language     = {eng},
  number       = {3},
  pages        = {230--238},
  title        = {Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2009.00453.x},
  volume       = {36},
  year         = {2009},
}

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