Ghent University Academic Bibliography

Advanced

Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs

Stijn Schauvliege UGent, Annelies Van den Eede UGent, Luc Duchateau UGent, Frederik Pille UGent, Lieven Vlaminck UGent and Frank Gasthuys UGent (2009) VETERINARY ANAESTHESIA AND ANALGESIA. 36(3). p.197-208
abstract
Objective To compare cardiac output (Qt) measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Study design Prospective randomized experimental cross-over trial. Animals Six ponies aged 5.0 +/- 1.6 (4-6.5) years and weighing 286 +/- 53 (212-368) kg. Methods After sedation (romifidine) and induction (midazolam + ketamine), anaesthesia was maintained with isoflurane in oxygen. After 90 minutes (= T0), one of four treatments was administered: saline 0.1 mL kg(-1) (S), enoximone 0.5 mg kg(-1) IV (E), enoximone followed by dobutamine (0.5 mu g kg(-1) minute(-1) for 120 minutes) (ED) or enoximone followed by a calcium chloride infusion (0.5 mg kg(-1) minute(-1) for 10 minutes) (EC). Data were recorded for 120 minutes after T0. The PulseCO (recorded from carotid artery) was calibrated before T0, no further recalibrations were performed. Qt was determined with LiDCO (Qt(LiDCO)) and PulseCO (Qt(PulseCO)) simultaneously at T5, T10, T20, T40, T60, T80, T100 and T120. Systemic vascular resistances (SVRLiDCO and SVRPulseCO) were calculated. Results In the saline group, Qt(PulseCO) was 4.9 +/- 12.3% lower than LiDCO (p < 0.01), whereas SVRPulseCO was 6.9 +/- 14.4% higher than SVRLiDCO (p < 0.01). These differences increased over time (mean +/- SEM), Qt by 0.06 +/- 0.03% minute(-1) (p = 0.042) and SVR by 0.08 +/- 0.03% minute(-1) (p = 0.018). Qt(PulseCO) was higher than Qt(LiDCO) in the EC group (1.8 +/- 23.3%), but lower than Qt(LiDCO) in groups E (-11.7 +/- 20.4%) and ED (-10.0 +/- 25.9%) (significant difference between treatments, p < 0.01). The differences in SVR in groups E (20.4 +/- 32.0%) and ED (20.7 +/- 35.3%) were significantly higher than in groups S (6.9 +/- 14.4%) and EC (3.1 +/- 22.2%) (p < 0.01). Conclusions and clinical relevance Pulse contour analysis values deviated significantly from LiDCO measurements in isoflurane-anaesthetized ponies. This difference was influenced by inotropic/vasoactive drugs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
inotropic treatment, cardiac output monitoring, isoflurane-anaesthetized ponies, lithium dilution, pulse contour analysis, TRANSESOPHAGEAL DOPPLER-ECHOCARDIOGRAPHY, CENTRAL AORTIC PRESSURE, STROKE VOLUME, HALOTHANE ANESTHESIA, DORSALLY RECUMBENT, VENTILATED PONIES, NEONATAL FOALS, WAVE-FORM, THERMODILUTION, HORSES
journal title
VETERINARY ANAESTHESIA AND ANALGESIA
Vet. Anaesth. Analg.
volume
36
issue
3
pages
197 - 208
Web of Science type
Article
Web of Science id
000264963900001
JCR category
VETERINARY SCIENCES
JCR impact factor
1.426 (2009)
JCR rank
35/141 (2009)
JCR quartile
1 (2009)
ISSN
1467-2987
DOI
10.1111/j.1467-2995.2009.00446.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
671651
handle
http://hdl.handle.net/1854/LU-671651
date created
2009-05-29 11:09:47
date last changed
2009-06-23 15:06:16
@article{671651,
  abstract     = {Objective To compare cardiac output (Qt) measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs.
Study design Prospective randomized experimental cross-over trial.
Animals Six ponies aged 5.0 +/- 1.6 (4-6.5) years and weighing 286 +/- 53 (212-368) kg.
Methods After sedation (romifidine) and induction (midazolam + ketamine), anaesthesia was maintained with isoflurane in oxygen. After 90 minutes (= T0), one of four treatments was administered: saline 0.1 mL kg(-1) (S), enoximone 0.5 mg kg(-1) IV (E), enoximone followed by dobutamine (0.5 mu g kg(-1) minute(-1) for 120 minutes) (ED) or enoximone followed by a calcium chloride infusion (0.5 mg kg(-1) minute(-1) for 10 minutes) (EC). Data were recorded for 120 minutes after T0. The PulseCO (recorded from carotid artery) was calibrated before T0, no further recalibrations were performed. Qt was determined with LiDCO (Qt(LiDCO)) and PulseCO (Qt(PulseCO)) simultaneously at T5, T10, T20, T40, T60, T80, T100 and T120. Systemic vascular resistances (SVRLiDCO and SVRPulseCO) were calculated.
Results In the saline group, Qt(PulseCO) was 4.9 +/- 12.3\% lower than LiDCO (p {\textlangle} 0.01), whereas SVRPulseCO was 6.9 +/- 14.4\% higher than SVRLiDCO (p {\textlangle} 0.01). These differences increased over time (mean +/- SEM), Qt by 0.06 +/- 0.03\% minute(-1) (p = 0.042) and SVR by 0.08 +/- 0.03\% minute(-1) (p = 0.018). Qt(PulseCO) was higher than Qt(LiDCO) in the EC group (1.8 +/- 23.3\%), but lower than Qt(LiDCO) in groups E (-11.7 +/- 20.4\%) and ED (-10.0 +/- 25.9\%) (significant difference between treatments, p {\textlangle} 0.01). The differences in SVR in groups E (20.4 +/- 32.0\%) and ED (20.7 +/- 35.3\%) were significantly higher than in groups S (6.9 +/- 14.4\%) and EC (3.1 +/- 22.2\%) (p {\textlangle} 0.01).
Conclusions and clinical relevance Pulse contour analysis values deviated significantly from LiDCO measurements in isoflurane-anaesthetized ponies. This difference was influenced by inotropic/vasoactive drugs.},
  author       = {Schauvliege, Stijn and Van den Eede, Annelies and Duchateau, Luc and Pille, Frederik and Vlaminck, Lieven and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keyword      = {inotropic treatment,cardiac output monitoring,isoflurane-anaesthetized ponies,lithium dilution,pulse contour analysis,TRANSESOPHAGEAL DOPPLER-ECHOCARDIOGRAPHY,CENTRAL AORTIC PRESSURE,STROKE VOLUME,HALOTHANE ANESTHESIA,DORSALLY RECUMBENT,VENTILATED PONIES,NEONATAL FOALS,WAVE-FORM,THERMODILUTION,HORSES},
  language     = {eng},
  number       = {3},
  pages        = {197--208},
  title        = {Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2009.00446.x},
  volume       = {36},
  year         = {2009},
}

Chicago
Schauvliege, Stijn, Annelies Van den Eede, Luc Duchateau, Frederik Pille, Lieven Vlaminck, and Frank Gasthuys. 2009. “Comparison Between Lithium Dilution and Pulse Contour Analysis Techniques for Cardiac Output Measurement in Isoflurane Anaesthetized Ponies: Influence of Different Inotropic Drugs.” Veterinary Anaesthesia and Analgesia 36 (3): 197–208.
APA
Schauvliege, S., Van den Eede, A., Duchateau, L., Pille, F., Vlaminck, L., & Gasthuys, F. (2009). Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. VETERINARY ANAESTHESIA AND ANALGESIA, 36(3), 197–208.
Vancouver
1.
Schauvliege S, Van den Eede A, Duchateau L, Pille F, Vlaminck L, Gasthuys F. Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. VETERINARY ANAESTHESIA AND ANALGESIA. 2009;36(3):197–208.
MLA
Schauvliege, Stijn, Annelies Van den Eede, Luc Duchateau, et al. “Comparison Between Lithium Dilution and Pulse Contour Analysis Techniques for Cardiac Output Measurement in Isoflurane Anaesthetized Ponies: Influence of Different Inotropic Drugs.” VETERINARY ANAESTHESIA AND ANALGESIA 36.3 (2009): 197–208. Print.