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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy

Ine Lentacker UGent (2009)
abstract
Cancer is a genetic disease, caused by mutations in the genome of normal cells. Chemical and physical damage to the cellular genome can induce these mutations resulting in the transformation of a healthy cell into a tumor cell. Over the past years, researchers have acquired a basic understanding of tumor onset. Several important proto-oncogenes and proteins involved in angiogenesis have been identified, leading to the development and clinical use of several new anticancer agents. We succeeded in preparing microbubbles which are able to carry genetic (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma cells upon ultrasound exposure. We also showed that the activity of currently available drug carriers (pDNA or siRNA lipoplexes and doxorubicin-liposomes) was significantly improved by microbubble coupling and ultrasound exposure. This enables us to obtain a space and time controlled drug delivery guided by ultrasound. The fact that ultrasound and microbubbles have already been approved for ultrasound contrast imaging and are currently used in daily clinic, makes it very plausible that the microbubble concept reported in this thesis may find its way as an advanced drug delivery system.
Please use this url to cite or link to this publication:
author
promoter
UGent, UGent and UGent
organization
alternative title
Ontwikkeling en evaluatie van geneesmiddel bevattende microbubbels voor ultrasound geleide kankertherapie
year
type
dissertation (monograph)
subject
keyword
MEDIATED TRANSFECTION, Ultrasound, CONTRAST AGENTS, Gene delivery, COATED MICROBUBBLES, INTRACELLULAR DELIVERY, Nuclear entry, Microbubbles, Liposomes, DRUG-DELIVERY, PLASMID DNA, LIPOSOMES
pages
216 pages
publisher
Ghent University. Faculty of Pharmaceutical Sciences
place of publication
Ghent, Belgium
defense location
Gent : Het Pand (zaal rector Blancquaert)
defense date
2009-05-18 17:00
language
English
UGent publication?
yes
classification
D1
copyright statement
I have retained and own the full copyright for this publication
id
671544
handle
http://hdl.handle.net/1854/LU-671544
alternative location
http://lib.ugent.be/fulltxt/RUG01/001/335/031/RUG01-001335031_2010_0001_AC.pdf
date created
2009-05-29 10:44:08
date last changed
2010-12-13 10:10:24
@phdthesis{671544,
  abstract     = {Cancer is a genetic disease, caused by mutations in the genome of normal cells. Chemical and physical damage to the cellular genome can induce these mutations resulting in the transformation of a healthy cell into a tumor cell. Over the past years, researchers have acquired a basic understanding of tumor onset. Several important proto-oncogenes and proteins involved in angiogenesis have been identified, leading to the development and clinical use of several new anticancer agents.
We succeeded in preparing microbubbles which are able to carry genetic (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma cells upon ultrasound exposure. We also showed that the activity of currently available drug carriers (pDNA or siRNA lipoplexes and doxorubicin-liposomes) was significantly improved by microbubble coupling and ultrasound exposure. This enables us to obtain a space and time controlled drug delivery guided by ultrasound. The fact that ultrasound and microbubbles have already been approved for ultrasound contrast imaging and are currently used in daily clinic, makes it very plausible that the microbubble concept reported in this thesis may find its way as an advanced drug delivery system.},
  author       = {Lentacker, Ine},
  keyword      = {MEDIATED TRANSFECTION,Ultrasound,CONTRAST AGENTS,Gene delivery,COATED MICROBUBBLES,INTRACELLULAR DELIVERY,Nuclear entry,Microbubbles,Liposomes,DRUG-DELIVERY,PLASMID DNA,LIPOSOMES},
  language     = {eng},
  pages        = {216},
  publisher    = {Ghent University. Faculty of Pharmaceutical Sciences},
  school       = {Ghent University},
  title        = {Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy},
  url          = {http://lib.ugent.be/fulltxt/RUG01/001/335/031/RUG01-001335031\_2010\_0001\_AC.pdf},
  year         = {2009},
}

Chicago
Lentacker, Ine. 2009. “Design and Evaluation of Drug Loaded Microbubbles for Ultrasound Guided Cancer Therapy”. Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
APA
Lentacker, I. (2009). Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy. Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium.
Vancouver
1.
Lentacker I. Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy. [Ghent, Belgium]: Ghent University. Faculty of Pharmaceutical Sciences; 2009.
MLA
Lentacker, Ine. “Design and Evaluation of Drug Loaded Microbubbles for Ultrasound Guided Cancer Therapy.” 2009 : n. pag. Print.