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Inflammatory mediators in Escherichia coli-induced mastitis in mice

Sofie Notebaert, Dieter Demon UGent, Tom Vanden Berghe UGent, Peter Vandenabeele UGent and Evelyne Meyer UGent (2008) COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES. 31(6). p.551-565
abstract
Escherichia coli (E coli) infections in mouse mammary glands are rarely described and poorly characterized. In order to investigate the host immune response during coliform mastitis, several inflammatory parameters were evaluated at 24 and 48 h following inoculation of mouse mammary glands with E coli. Successfully challenged mice showed high values of the acute phase protein serum amyloid A (SAA) in blood. Systemic concentrations of the major inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were also increased as compared to control mice, while interleukin-1 (IL-1) levels remained negligible. Infected mammary glands showed a significant increase of all cytokine levels as compared to control glands. In accordance, mammary expression of the biologically inactive proform of IL-1 beta was strongly up-regulated. Remarkably, data obtained in wild type as well as caspase-1 knockout mice showed that IL-1 beta maturation seemed to occur independently from caspase-1. Finally, E coli infection also triggered activation of the nuclear transcription factor-kappa B (NF-kappa B) in the mammary gland. In conclusion, the current study provides novel insights on the contribution of major regulatory proteins to the acute inflammatory host response at the local and systemic level during E coli mastitis in mice.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Comp. Immunol. Microbiol. Infect. Dis.
volume
31
issue
6
pages
551 - 565
Web of Science type
Article
Web of Science id
000261669400010
JCR category
VETERINARY SCIENCES
JCR impact factor
1.607 (2008)
JCR rank
22/133 (2008)
JCR quartile
1 (2008)
ISSN
0147-9571
DOI
10.1016/j.cimid.2007.10.004
language
English
UGent publication?
yes
classification
A1
id
669857
handle
http://hdl.handle.net/1854/LU-669857
date created
2009-05-28 09:37:32
date last changed
2012-06-26 14:31:38
@article{669857,
  abstract     = {Escherichia coli (E coli) infections in mouse mammary glands are rarely described and poorly characterized. In order to investigate the host immune response during coliform mastitis, several inflammatory parameters were evaluated at 24 and 48 h following inoculation of mouse mammary glands with E coli. Successfully challenged mice showed high values of the acute phase protein serum amyloid A (SAA) in blood. Systemic concentrations of the major inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were also increased as compared to control mice, while interleukin-1 (IL-1) levels remained negligible. Infected mammary glands showed a significant increase of all cytokine levels as compared to control glands. In accordance, mammary expression of the biologically inactive proform of IL-1 beta was strongly up-regulated. Remarkably, data obtained in wild type as well as caspase-1 knockout mice showed that IL-1 beta maturation seemed to occur independently from caspase-1. Finally, E coli infection also triggered activation of the nuclear transcription factor-kappa B (NF-kappa B) in the mammary gland. In conclusion, the current study provides novel insights on the contribution of major regulatory proteins to the acute inflammatory host response at the local and systemic level during E coli mastitis in mice.},
  author       = {Notebaert, Sofie and Demon, Dieter and Vanden Berghe, Tom and Vandenabeele, Peter and Meyer, Evelyne},
  issn         = {0147-9571},
  journal      = {COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES},
  language     = {eng},
  number       = {6},
  pages        = {551--565},
  title        = {Inflammatory mediators in Escherichia coli-induced mastitis in mice},
  url          = {http://dx.doi.org/10.1016/j.cimid.2007.10.004},
  volume       = {31},
  year         = {2008},
}

Chicago
Notebaert, Sofie, Dieter Demon, Tom Vanden Berghe, Peter Vandenabeele, and Evelyne Meyer. 2008. “Inflammatory Mediators in Escherichia Coli-induced Mastitis in Mice.” Comparative Immunology Microbiology and Infectious Diseases 31 (6): 551–565.
APA
Notebaert, Sofie, Demon, D., Vanden Berghe, T., Vandenabeele, P., & Meyer, E. (2008). Inflammatory mediators in Escherichia coli-induced mastitis in mice. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 31(6), 551–565.
Vancouver
1.
Notebaert S, Demon D, Vanden Berghe T, Vandenabeele P, Meyer E. Inflammatory mediators in Escherichia coli-induced mastitis in mice. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES. 2008;31(6):551–65.
MLA
Notebaert, Sofie, Dieter Demon, Tom Vanden Berghe, et al. “Inflammatory Mediators in Escherichia Coli-induced Mastitis in Mice.” COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES 31.6 (2008): 551–565. Print.