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Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies

Stephanie Van Weyenberg UGent, Johan Buyse and Geert Janssens UGent (2009) JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION. 93(2). p.203-208
abstract
In this study 0 or 4 g of l-carnitine was supplemented for 7 days in a cross-over design of six healthy ponies to modulate glucose metabolism and leptin production. At the end of each period, serial blood samples were taken to measure glucose and insulin response, leptin, triglyceride (TG), non-esterified fatty acids (NEFA) and creatine phosphokinase. l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance. In contrast, postprandial plasma leptin concentration was increased when l-carnitine was supplemented. Yet, this increase in leptin concentration was not preceded by an increase in insulin concentration, suggesting that other factors apart from plasma insulin concentration could influence plasma leptin concentration. Although NEFA and TG were not significantly influenced by l-carnitine supplementation under these experimental conditions, further research must clarify whether net TG synthesis might be responsible for this increase in leptin.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
leptin, glucose tolerance, carnitine, equine, DIURNAL RHYTHM, FATTY-ACID, METABOLISM, OXIDATION, DISPOSAL, MARES, DIET, MEAL, RATS
journal title
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
J. Anim. Physiol. Anim. Nutr.
volume
93
issue
2
pages
203 - 208
Web of Science type
Article
Web of Science id
000264025200008
JCR category
VETERINARY SCIENCES
JCR impact factor
1.229 (2009)
JCR rank
44/141 (2009)
JCR quartile
2 (2009)
ISSN
0931-2439
DOI
10.111/j.1439-0396.2008.00807.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
668668
handle
http://hdl.handle.net/1854/LU-668668
date created
2009-05-27 12:20:18
date last changed
2009-06-19 15:08:49
@article{668668,
  abstract     = {In this study 0 or 4 g of l-carnitine was supplemented for 7 days in a cross-over design of six healthy ponies to modulate glucose metabolism and leptin production. At the end of each period, serial blood samples were taken to measure glucose and insulin response, leptin, triglyceride (TG), non-esterified fatty acids (NEFA) and creatine phosphokinase. l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance. In contrast, postprandial plasma leptin concentration was increased when l-carnitine was supplemented. Yet, this increase in leptin concentration was not preceded by an increase in insulin concentration, suggesting that other factors apart from plasma insulin concentration could influence plasma leptin concentration. Although NEFA and TG were not significantly influenced by l-carnitine supplementation under these experimental conditions, further research must clarify whether net TG synthesis might be responsible for this increase in leptin.},
  author       = {Van Weyenberg, Stephanie and Buyse, Johan and Janssens, Geert},
  issn         = {0931-2439},
  journal      = {JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION},
  keyword      = {leptin,glucose tolerance,carnitine,equine,DIURNAL RHYTHM,FATTY-ACID,METABOLISM,OXIDATION,DISPOSAL,MARES,DIET,MEAL,RATS},
  language     = {eng},
  number       = {2},
  pages        = {203--208},
  title        = {Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies},
  url          = {http://dx.doi.org/10.111/j.1439-0396.2008.00807.x},
  volume       = {93},
  year         = {2009},
}

Chicago
Van Weyenberg, Stephanie, Johan Buyse, and Geert Janssens. 2009. “Increased Plasma Leptin Through L-carnitine Supplementation Is Associated with an Enhanced Glucose Tolerance in Healthy Ponies.” Journal of Animal Physiology and Animal Nutrition 93 (2): 203–208.
APA
Van Weyenberg, S., Buyse, J., & Janssens, G. (2009). Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 93(2), 203–208.
Vancouver
1.
Van Weyenberg S, Buyse J, Janssens G. Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION. 2009;93(2):203–8.
MLA
Van Weyenberg, Stephanie, Johan Buyse, and Geert Janssens. “Increased Plasma Leptin Through L-carnitine Supplementation Is Associated with an Enhanced Glucose Tolerance in Healthy Ponies.” JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION 93.2 (2009): 203–208. Print.