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Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies

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Abstract
In this study 0 or 4 g of l-carnitine was supplemented for 7 days in a cross-over design of six healthy ponies to modulate glucose metabolism and leptin production. At the end of each period, serial blood samples were taken to measure glucose and insulin response, leptin, triglyceride (TG), non-esterified fatty acids (NEFA) and creatine phosphokinase. l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance. In contrast, postprandial plasma leptin concentration was increased when l-carnitine was supplemented. Yet, this increase in leptin concentration was not preceded by an increase in insulin concentration, suggesting that other factors apart from plasma insulin concentration could influence plasma leptin concentration. Although NEFA and TG were not significantly influenced by l-carnitine supplementation under these experimental conditions, further research must clarify whether net TG synthesis might be responsible for this increase in leptin.
Keywords
leptin, glucose tolerance, carnitine, equine, DIURNAL RHYTHM, FATTY-ACID, METABOLISM, OXIDATION, DISPOSAL, MARES, DIET, MEAL, RATS

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Chicago
Van Weyenberg, Stephanie, Johan Buyse, and Geert Janssens. 2009. “Increased Plasma Leptin Through L-carnitine Supplementation Is Associated with an Enhanced Glucose Tolerance in Healthy Ponies.” Journal of Animal Physiology and Animal Nutrition 93 (2): 203–208.
APA
Van Weyenberg, S., Buyse, J., & Janssens, G. (2009). Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 93(2), 203–208.
Vancouver
1.
Van Weyenberg S, Buyse J, Janssens G. Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION. 2009;93(2):203–8.
MLA
Van Weyenberg, Stephanie, Johan Buyse, and Geert Janssens. “Increased Plasma Leptin Through L-carnitine Supplementation Is Associated with an Enhanced Glucose Tolerance in Healthy Ponies.” JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION 93.2 (2009): 203–208. Print.
@article{668668,
  abstract     = {In this study 0 or 4 g of l-carnitine was supplemented for 7 days in a cross-over design of six healthy ponies to modulate glucose metabolism and leptin production. At the end of each period, serial blood samples were taken to measure glucose and insulin response, leptin, triglyceride (TG), non-esterified fatty acids (NEFA) and creatine phosphokinase. l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance. In contrast, postprandial plasma leptin concentration was increased when l-carnitine was supplemented. Yet, this increase in leptin concentration was not preceded by an increase in insulin concentration, suggesting that other factors apart from plasma insulin concentration could influence plasma leptin concentration. Although NEFA and TG were not significantly influenced by l-carnitine supplementation under these experimental conditions, further research must clarify whether net TG synthesis might be responsible for this increase in leptin.},
  author       = {Van Weyenberg, Stephanie and Buyse, Johan and Janssens, Geert},
  issn         = {0931-2439},
  journal      = {JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION},
  keyword      = {leptin,glucose tolerance,carnitine,equine,DIURNAL RHYTHM,FATTY-ACID,METABOLISM,OXIDATION,DISPOSAL,MARES,DIET,MEAL,RATS},
  language     = {eng},
  number       = {2},
  pages        = {203--208},
  title        = {Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies},
  url          = {http://dx.doi.org/10.111/j.1439-0396.2008.00807.x},
  volume       = {93},
  year         = {2009},
}

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